Inflammatory bowel disease in IL-2 deficient mice requires T, but not B lymphocytes

Ma, Atoba; Datta, Merrilyn; Margosian, E.; Horak, E.; Alt, Francesca

doi:10.1016/0016-5085(95)27774-9

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“…mice which lack different distinct immunoregulatory genes, develop intestinal inflammation in the presence of intestinal flora, but improve under germ-free conditions [9]. Under such circumstances T cells, but not B cells, seem to be required to produce intestinal inflammation [9,10]. Furthermore, models using conventional animals such as a rat model of chronic granulomatous enterocolitis induced by injection of bacterial cell wall fragments [11] or a rabbit model of acute immune complex colitis, in which chronic colitis is induced by pre-sensitization to colonic bacterial antigens [12], also establish that interactions between the immune system and microbial products may result in chronic intestinal inflammation.…”

Section: Introductionmentioning

confidence: 99%

Bacteria‐Specific T‐Cell Clones are Selective in their Reactivity Towards Different Enterobacteria or H. pylori and Increased in Inflammatory Bowel Disease

1996

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In the present study the authors investigated the T-cell response to different enterobacteria or Helicobacter pylori and tested the hypothesis that the frequency of bacteria-specific T cells is increased in the intestine of patients with active inflammatory bowel disease (IBD), i.e. Crohn's disease (CD) and ulcerative colitis (UC). The analysis of a large panel of T-cell clones (Tc) (n = 888) from peripheral blood, non-inflamed and inflamed intestine from IBD patients and control individuals shows that both peripheral blood and intestinal T-cell clones were selectively stimulated by either Salmonella typhimurium, Yersinia enterocolitica 03, Escherichia coli or Helicobacter pylori sonicates, that only < 3% of all bacteria-reactive Tc were crossreactive and that proliferation to bacterial sonicates was inhibited by anti-MHC class II antibody. In addition, bacteria-specific Tc from IBD patients were more frequently isolated from inflamed intestine than from peripheral blood (P = 0.0039) or non-inflamed intestine. These data, from a large number of T-cell clones, are the first systematic analysis describing the response of individual T cells towards different bacterial species (ssp.). They show that T cells with specificity for distinct antigens or superantigens that are characteristic for a defined bacteria ssp. are present in normal, and increased in inflamed, IBD-intestine. These bacteria-specific Tc may play a role in IBD pathogenesis.

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