Inflammatory Bowel Disease in Childhood and Adolescence

Däbritz, Jan; Gerner, Patrick; Enninger, Axel; Claßen, Martin; Radkë, Michaël

doi:10.3238/arztebl.2017.0331

Cited by 46 publications

(37 citation statements)

References 87 publications

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“…The most common extra-intestinal manifestation of IBDs, particularly CD, in childhood and adolescence is reported to be impaired physical growth[ 24 ]. This was found in the present study, where almost one-third of our patients was on the 3 rd percentile or lower for body weight, while 27.1% had short stature[ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatobiliary manifestations in children with inflammatory bowel disease: A single-center experience in a low/middle income country

El-Shabrawi¹,

Tarek²,

Abou-Zekri³

et al. 2020

WJGPT

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BACKGROUND There has been a worldwide increase in the reported incidence of inflammatory bowel disease (IBD) in children over the past 2-3 decades. The hepatobiliary (HB) manifestations of IBD have been well-studied in children in industrialized and developed countries but are infrequently reported in low- and middle-income countries (LMIC) such as Egypt. AIM To determine the prevalence of the HB manifestations in a cohort of Egyptian children with IBD. METHODS This cross-sectional observational study was carried out over a period of 6 mo (between June 2013 to December 2013) at the Paediatric Hepatology and Gastroenterology Units of Cairo University Children's Hospital, which is the largest paediatric tertiary care centre in the country. RESULTS The study included 48 patients with confirmed IBD based upon clinical, laboratory, endoscopic and histopathological features, 29 (60.4%) were male. Twenty-four patients (50%) had ulcerative colitis (UC), 11 (22.9%) had Crohn's disease (CD) and 13 (27.1%) had unclassified-IBD (IBD-U), which was formerly known as indeterminate colitis. The mean age of the patients at the time of presentation was 8.14 (± SD 4.02) years and the mean age at the time of study enrolment was 10.16 (± SD 4.19) years. All patients were screened for HB manifestations by physical examination, liver function tests, imaging and liver biopsy when indicated. HB disorders were confirmed in 13 patients (27.1%). Transaminases were elevated in 3 patients (6.3%). Two patients (4.2%) had elevated biliary enzymes (one was diagnosed as primary sclerosing cholangitis (PSC) and the other was diagnosed with PSC/autoimmune hepatitis overlap syndrome and the third patient had hepatitis C virus infection. Ten patients (20.8%) had bright echogenic liver on ultrasound suggesting fatty infiltration as a sequel of malnutrition or medication toxicity. CONCLUSION The commonest HB disorders in Egyptian children with IBD were abnormal liver function tests, fatty infiltration and PSC. These HB manifestations in paediatric patients in LMIC may be relatively more common than in industrialized countries. Therefore, IBD patients in LMIC should be meticulously screened for liver disease to allow prompt diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Hepatobiliary manifestations in children with inflammatory bowel disease: A single-center experience in a low/middle income country

El-Shabrawi¹,

Tarek²,

Abou-Zekri³

et al. 2020

WJGPT

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“…100-200 pro 100 000 Einwohner. Für die Inzidenz der Colitis ulcerosa wird in Deutschland eine Zahl zwischen 3-3,9 pro 100 000 Einwohner und eine Prävalenz zwischen 160-250 pro 100 000 Einwohner angegeben [2]. Für Kinder werden Inzidenzraten von 5-11 pro 100 000 Kinder und Jugendliche unter 18 Jahren für die chronisch entzündlichen Darmerkrankungen zitiert [3].…”

Section: Definition Und äTiologieunclassified

Chronisch entzündliche Darmerkrankungen

Wirth¹

2020

Pädiatrie up2date

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“…In the preceding years of transfer (between 16 and 18 years of age), adolescents are in a vulnerable phase when failing to receive sufficient care may result in a drop in adherence, therapy discontinuation, and a consequent increase in complication rates. Since transfer to adult care has several pitfalls, suitable transition models with structured programs have been introduced (Dabritz, Gerner, Enninger, Classen, & Radke, 2017). The benefits of these models have long been confirmed in chronically ill adolescents with cystic fibrosis, type 1 diabetes mellitus, juvenile rheumatoid arthritis, and congenital heart diseases (Afzali & Wahbeh, 2017;Hewer & Tyrrell, 2008;Monaghan & Baumann, 2016).…”

Section: Introductionmentioning

confidence: 99%

Planned Transition of Adolescent Patients with Inflammatory Bowel Disease Results in Higher Remission Rates

Otto

Tárnok

Erős

et al. 2019

Journal of Pediatric Nursing

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Purpose: To evaluate the effect of our current transition process on clinical outcomes in adolescent patients with inflammatory bowel diseases (IBD). Design and methods: Two groups of patients with IBD diagnosed in pediatric care were compared retrospectively: Group A patients did not attend the transition process, while Group B patients entered the planned transition service. Outcomes at 1-year after transfer to adult care were evaluated. Results: Forty-five patients with IBD diagnosed under the age of 18 years were identified of whom 35 had Crohn's disease and 10 had ulcerative colitis. Twenty-four patients were in Group A (without transition), and 21 patients in Group B (with at least one planned transition visit). Mean age at diagnosis was 15.1 ± 2.2 and 13.7 ± 3.0 years (p = 0.086), respectively. There were no significant differences in disease duration before transfer, Montreal classification at diagnosis, body mass index, anti-TNF therapy usage, and disease status at transfer between the two groups. A significantly higher number of Group B patients were in remission at 12 months after transfer when compared to patients in Group A (11 vs. 18, respectively, p = 0.037). There was a significant difference between groups regarding the number of scheduled visits within the examined period (9 vs. 16, p = 0.011, respectively). Conclusions: Planned transition visits resulted in higher disease remission rate at 1-year follow-up after transfer from pediatric to adult health care system in adolescent patients with IBD. Practice implication: Well-established transition programs in IBD are needed.

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Inflammatory Bowel Disease in Childhood and Adolescence

Abstract: SUMMARYBackground: The incidence of inflammatory bowel disease (IBD) in childhood and adolescence is 5-11 cases per 100 000 persons per year, corresponding to a new diagnosis of IBD in 800-1470 patients in Germany each year.

Cited by 46 publications

References 87 publications

Hepatobiliary manifestations in children with inflammatory bowel disease: A single-center experience in a low/middle income country

Hepatobiliary manifestations in children with inflammatory bowel disease: A single-center experience in a low/middle income country

Chronisch entzündliche Darmerkrankungen

Planned Transition of Adolescent Patients with Inflammatory Bowel Disease Results in Higher Remission Rates

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