Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and Non-Hispanic Whites: Characterization of a Large North American Cohort

Nguyen, Geoffrey C.; Torres, Esther A.; Regueiro, Miguel; Bromfield, Gillian; Bitton, Alain; Stempak, Joanne M.; Dassopoulos, Themistocles; Schumm, L. Philip; Gregory, Federico; Griffiths, Anne M.; Hanauer, Stephen B.; Hanson, Jennifer; Harris, Mary L.; Kane, Sunanda V.; Orkwis, Heather Kiraly; Lahaie, Raymond G.; Oliva-Hemker, Maria; Paré, Pierre; Wild, Gary; Rioux, John D.; Yang, Huiying; Duerr, Richard H.; Cho, Judy H.; Steinhart, A. Hillary; Brant, Steven R.; Silverberg, Mark S.

doi:10.1111/j.1572-0241.2006.00504.x

Cited by 243 publications

(220 citation statements)

References 31 publications

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“…The clinical features of this sample collection has recently been published. 54 Of note, sample collection 'IBD-3' consists of samples from four independent collections. Collection 1 from the Erasme Hospital, Brussels, Belgium: 179 subjects affected with CD.…”

Section: Subjectsmentioning

confidence: 99%

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

et al. 2007

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The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P ¼ 0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P ¼ 0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04-1.30; P ¼ 0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway -in this case, TLR4 and its signaling molecule TIRAP -plays a role in susceptibility to IBD.

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Section: Subjectsmentioning

confidence: 99%

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

et al. 2007

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“…Distribution of IBD disease location as defined by Montreal Classification variables was similar to that reported in a large diverse referral cohort, though the reported median age at diagnosis of 48 years was older than expected [11,12]. Similarly, the cohort proportion of B3 (penetrating) phenotype was relatively higher at the expense of B1 (non-stricturing/non-penetrating), possibly reflecting disease duration and diagnostic delay.…”

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confidence: 52%

Radiating Disparity in IBD

Flasar

Patil

2013

Dig Dis Sci

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“…Marked phenotypic racial differences were revealed also in anatomic location of IBD expression. African Americans compared with other US ethnic groups had higher predisposition for Crohn's in the colorectum and at the perianal area but less frequently in the terminal small bowel (27).…”

Section: Infl Ammatory Bowel Disease and Colorectal Cancermentioning

confidence: 99%

Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe

Simko¹,

Ginter²

2016

BLL

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Inflammatory Bowel Disease Characteristics Among African Americans, Hispanics, and Non-Hispanic Whites: Characterization of a Large North American Cohort

Abstract: There are racial differences in IBD family history, disease location, and EIMs that may reflect underlying genetic variations and have important implications for diagnosis and management of disease. These findings underscore the need for further studies in minority populations.

Cited by 243 publications

References 31 publications

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

Radiating Disparity in IBD

Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe

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