Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis

Guo, Lin; Liu, Yi; Li, Jiansheng; Liu, Quan; Liu, Bing; Shi, Xuewen

doi:10.1097/md.0000000000033113

Cited by 3 publications

(1 citation statement)

References 41 publications

(89 reference statements)

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“…However, when using a total laparoscopic approach, similar pregnancy rates were reported in patients having ileal pouch-anal anastomosis for UC or familial adenomatous polyposis (67%) and control patients (71%) who had undergone laparoscopic appendectomy [22]. Furthermore, a very recent meta-analysis (2023) investigated the role of IBD in ovarian reserve functions [23]. The authors included seven original studies and drew the conclusion that female IBD patients can have decreased ovarian reserve function.…”

Section: Males Trying To Conceivementioning

confidence: 82%

Childlessness in Patients with Inflammatory Bowel Disease – Data from the Prospective Multi-center Swiss IBD Cohort Study

Sulz,

Doulberis,

Fournier

et al. 2023

JGLD

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Background and Aims: Childlessness and infertility represent a frequent and important issue in inflammatory bowel disease (IBD) patients. Nevertheless, until now epidemiological data remains scarce. Therefore, main objectives of this study were to evaluate the rate of childlessness and the cumulative probability of reproduction in female and male IBD patients within the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS), a large prospective multicenter nationwide cohort. Methods: Prospectively collected data of SIBDCS was used, comprising more than 3,300 patients with Crohn’s disease (CD) and ulcerative colitis (UC). We analyzed the following groups of patients: 1) female IBD patients aged ≥40 years and diagnosed before age of 30 years with at least one follow-up, 2) female IBD patients who reported actively trying to conceive, with IBD diagnosed <35 years and with age at enrolment <45 years (longitudinal observation), with at least one follow-up, and 3) childless males who actively tried to conceive. Results: A total of 1,412 female patients from the SIBDCS [843 CD, 539 UC, 30 indeterminate colitis (IC)] with available data were included in our analyses. Out of those 184 females (70.1% CD and 29.9 % UC) were aged ≥ 40 years and have been diagnosed with IBD before the age of 30 years. Among these, 184 women 32.1% were childless. The portion of childless females (36.4%) was significantly higher in CD vs. UC (36.4% vs. 21.8%; p=0.026), equaling a relative risk of childlessness of 1.7 in CD vs. UC. and higher than in the Swiss general population (21%). The mean number of children per female patient was 1.32 (median 1, min 0, max 6), per female with CD 1.12 (median 1, min 0, max 4), per female with UC/IC 1.78 (median 2, min 0, max 6; P=0.001). The longitudinal analysis of female IBD patients trying to conceive revealed that one out of two women neither were pregnant nor had born a child five years after first trying to conceive. Conclusions: The rate of childlessness in females with CD is higher compared to the general Swiss population, whereas it is similar in women with UC. Moreover, the mean number of children is lower in CD than in UC. Females with CD remain more often childless compared to their UC counterparts. Although the exact underlying mechanisms are largely unknown, this discrepancy should alert healthcare professionals treating CD patients to actively address this topic.

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Section: Males Trying To Conceivementioning

confidence: 82%

Childlessness in Patients with Inflammatory Bowel Disease – Data from the Prospective Multi-center Swiss IBD Cohort Study

Sulz,

Doulberis,

Fournier

et al. 2023

JGLD

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Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications

Zeng,

Wang,

Yang

et al. 2024

Human Reproduction

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Ovarian aging, a natural process in women and various other female mammals as they age, is characterized by a decline in ovarian function and fertility due to a reduction in oocyte reserve and quality. This phenomenon is believed to result from a combination of genetic, hormonal, and environmental factors. While these factors collectively contribute to the shaping of ovarian aging, the substantial impact and intricate interplay of chronic inflammation in this process have been somewhat overlooked in discussions. Chronic inflammation, a prolonged and sustained inflammatory response persisting over an extended period, can exert detrimental effects on tissues and organs. This review delves into the novel hallmark of aging—chronic inflammation—to further emphasize the primary characteristics of ovarian aging. It endeavors to explore not only the clinical symptoms but also the underlying mechanisms associated with this complex process. By shining a spotlight on chronic inflammation, the aim is to broaden our understanding of the multifaceted aspects of ovarian aging and its potential clinical implications.

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Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis

Foulon,

Richard,

Guichard

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionIt is still unclear whether Crohn's disease (CD) might be associated with diminished ovarian reserve (OvR) and factors influencing anti‐Mullerian hormone (AMH) levels in CD are poorly known.Material and MethodsWe conducted a comprehensive literature search of multiple electronic databases from inception to June 2022 to identify all studies reporting AMH levels or factors associated with diminished OvR in patients with CD.ResultsOf the 48 studies identified in our search, eight (including 418 patients with CD) were finally included. The mean difference (95% confidence interval [CI]) in the AMH level between pooled CD patients and controls was −0.56 (−1.14 to 0.03) (p = 0.06). A history of CD‐related surgery was not associated with a lower OvR (odds ratio, OR [95% CI] 1.34, [0.66–2.7]; p = 0.4). While disease activity and perianal disease seems associated with a low OvR, disease location (L2 vs. L1, OR [95% CI] = 95% CI [0.47–7.4]; p = 0.4) and L3 vs. L1 (OR [95% CI] = 1.44 [0.67–3.12]; p = 0.3), CD medication, and disease behavior were not.ConclusionsOur systematic review and meta‐analysis did not identify a significantly low OvR in patients with CD. Contrary to CD‐related surgery risk factor, active disease was associated lower AMH levels.

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Inflammatory bowel disease can reduce ovarian reserve function in women: A systematic review and meta-analysis

Cited by 3 publications

References 41 publications

Childlessness in Patients with Inflammatory Bowel Disease – Data from the Prospective Multi-center Swiss IBD Cohort Study

Childlessness in Patients with Inflammatory Bowel Disease – Data from the Prospective Multi-center Swiss IBD Cohort Study

Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications

Factors associated with decreased ovarian reserve in Crohn's disease: A systematic review and meta‐analysis

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