Inflammatory bowel disease and the risk of prostate cancer.

Kundu, Shilajit; Burns, Jacob A.; Weiner, Adam B.; Catàlona, William J.; Schaeffer, Edward M.; Vashi, Ronak; Li, Eric; Hanauer, Stephen B.; Strong, Scott A.; Burns, James; Hussain, Maha

doi:10.1200/jco.2018.36.15_suppl.e17052

Cited by 1 publication

(3 citation statements)

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“…This finding suggests that IBD, especially UC, may increase the risk of incidence of PC compared to controls. The explanations for these results are multifactorial [3,[12][13][14][15][16][17][18][19][20][21][22][23][24] .…”

Section: Discussionmentioning

confidence: 95%

“…We found 1,050 different studies in total, 14 of which from 2001 to 2020 met the inclusion criteria and were included in the analysis [3,[12][13][14][15][16][17][18][19][20][21][22][23][24] . The data of these studies are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…This meta-analysis was founded on 14 studies, comprising 127,323 subjects with IBD, at the baseline of the study, among which 61,985 had UC and 37,802 had CD [3,[12][13][14][15][16][17][18][19][20][21][22][23][24] . In comparison to the control group, patients with UC and IBD had a considerably increased incidence of PC [6,[20][21][22][23][24][25][26][27][28][29][30][31][32] . However, with regard to the prevalence of PC, there was no discernible difference between CD and the control group.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Bowel Disease Patients’ Risk of Developing Prostate Cancer: A Meta-Analysis

Amin

Nicola

Abdelrahim

2023

JCNR

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Background: Inflammatory bowel disease (IBD) has been linked to an increased risk of prostate cancer (PC) in numerous studies. However, the exact relationship between them remains conflicting. In this meta-analysis, we focus on determining the relationship between PC incidence and IBD. Methods: A comprehensive literature search was conducted up until January 2022, selecting 14 studies, comprising 127,323 subjects with IBD, at the beginning of the study, among which 61,985 were patients with ulcerative colitis (UC) and 37,802 were with Crohn’s disease (CD). The studies reported the differences between subjects with IBD and controls with regard to the incidence of PC. In order to investigate the relationship between IBD and the prevalence of PC, we estimated the odds ratio (OR) with 95% confidence intervals (CIs). Results: IBD significantly increased the incidence of PC (OR, 3.46; 95% CI, 1.40–8.54, P = 0.007) compared to controls. UC significantly increased the incidence of PC (OR, 1.43; 95% CI, 1.03–1.98, P = 0.03) compared to controls. Yet, no significant difference was observed between CD and controls in relation to PC incidence (OR, 0.89; 95% CI, 0.75–1.06, P = 0.18). Conclusion: IBD, particularly UC, may increase the risk of developing PC. This relationship prompts us to advocate for increased PC and IBD screening to reduce the risk for possible complications that could occur in these subjects.

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