Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure
Guoling Cao,
Qinghua Luo,
Yunxiang Wu
et al.
Abstract:BackgroundThe comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high rate remain unclear. Their similar genetic makeup probably contributes to this comorbidity.MethodsBased on data obtained from the genome-wide association study of IBD and RA, we first assessed an overall genetic association by performing the linkage disequilibrium score regression (LDSC) analysis. Further, a local correlation analysis was performed by estimating t… Show more
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