Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review

Ronchetti, Camilla; Cirillo, Federico; Segni, Noemi Di; Cristodoro, Martina; Busnelli, Andrea; Levi-Setti, Paolo Emanuele

doi:10.3390/nu14081591

Cited by 16 publications

(14 citation statements)

References 94 publications

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“…In contrast, the autoimmune protocol diet (AID) had a higher subclinical response rate and a lower relapse rate than the control group, which may have been due to changes in the AID group's metabolome and microbiome that reduced inflammation [5]. According to another study, adhering to a strict diet that includes fruits, vegetables, and whole grains while limiting red meat, processed foods, and dairy products can help reduce symptoms and improve the quality of life in patients with UC [35][36][37]. Many IBD patients believe that their diet causes flare-ups and avoid their favorite foods as a result.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Role of Diet in Ulcerative Colitis

Abbas¹,

Shakil²,

Rana³

et al. 2023

Cureus

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by inflammation and ulceration of the colon and rectum. Diet is an important part of UC management because it can either aggravate or alleviate symptoms along with medication therapy. A comprehensive literature search was conducted using multiple databases (PubMed and Online Wiley Library) and search engines (Google Scholar) using specific keywords related to UC and diet. The search resulted in a large number of articles, which were then narrowed down by focusing on clinical trials and randomized controlled trials published between 2010 and 2023. According to the research, certain dietary interventions, such as the low FODMAP diet, the Mediterranean diet, and the anti-inflammatory diet, appear to improve symptoms and overall quality of life. Dietary interventions have the potential to help with UC management. The goal should be to provide patients with tailored dietary interventions and other treatments to improve their quality of life. More research is needed to identify the most effective dietary interventions and better understand how they work.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Role of Diet in Ulcerative Colitis

Abbas¹,

Shakil²,

Rana³

et al. 2023

Cureus

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“…Gut microbiota dysbiosis and inflammation in the colonic epithelium are related to gut leak, which damages the integrity of the intestinal barrier and leads to microbes and bacterial metabolites entering host circulation, inducing infections and diseases [ 85 ] ( Figure 1B ). For example, several studies have indicated that the fertility of women may be impaired when they suffer from inflammatory bowel disease (IBD) [ 89 ]. Other studies have also observed a higher risk of pregnancy complications such as spontaneous abortion and preterm labor in women with gut inflammation [ 90 ], suggesting an immune interaction between gut and FRT ( Figure 1C ).…”

Section: Impact Of Lifestyle On Gut Microbiome and Reproductive Healthmentioning

confidence: 99%

Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies

Xiao,

Zuo,

Zhao

2023

Genomics, Proteomics &Amp; Bioinformatics

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The microbiome plays a critical role in the process of conception and the outcomes of pregnancy. Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications, which significantly impact maternal and fetal health. Recent studies have associated the microbiome in the female reproductive tract (FRT) with assisted reproductive technology (ART) outcomes, and restoring microbiome balance has been shown to improve fertility in infertile couples. This review provides an overview of the role of the microbiome in female reproductive health, including its implications for pregnancy outcomes and ARTs. Additionally, recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized. A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health. Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.

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“…Therefore, most women with IBD are affected during their reproductive years, with fear, uncertainty, and poor knowledge of how the disease can impact their life. 2 , 3 The current literature reports that IBD women experience an higher prevalence of voluntary childlessness, 4 – 6 drug interruption immediately before or during pregnancy, 7 , 8 and a lower rate of breastfeeding compared to healthy women. 9 …”

Section: Introductionmentioning

confidence: 99%

Impact of inflammatory bowel disease on women’s reproductive life: a questionnaire-based study

Zingone,

Borsato,

Maniero

et al. 2024

Therap Adv Gastroenterol

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Background: Inflammatory bowel diseases (IBDs) have a peak incidence between the second and fourth decades of life and can affect women’s reproductive life. Objectives: Our study aimed to assess the impact of IBD on the reproductive life of female patients with this condition. Design: Cross-sectional study. Methods: Women with IBD followed at our IBD Unit and a group of healthy controls were enrolled. Data on reproductive life were collected using a dedicated questionnaire. Results: The study included 457 women, of whom 228 had IBD, and 229 age-matched healthy controls. No differences were found in the use of contraceptives, infertility, and endometriosis. The risk of spontaneous and voluntary abortions was significantly higher in IBD patients than in healthy controls [odds ratio (OR) 2 and 3.62, respectively]. The risk of obstetrical complications in the IBD population was more than six times higher in patients who experienced disease reactivations during pregnancy than in those with persistent remission [OR 6.9, 95% confidence interval (CI) 1.51–31.28]. Finally, we found that the chances of breastfeeding were 66% lower in patients with IBD than in controls (OR 0.44, 95% CI 0.22–0.91). Conclusion: Our study underlines the negative impact of IBD on women’s reproductive life, supporting the need for proactive preconception counseling.

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Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy—A Narrative Review

Cited by 16 publications

References 94 publications

A Systematic Review of the Role of Diet in Ulcerative Colitis

A Systematic Review of the Role of Diet in Ulcerative Colitis

Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies

Impact of inflammatory bowel disease on women’s reproductive life: a questionnaire-based study

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