Inflammatory Bowel Disease and Parkinson’s Disease: A Nationwide Swedish Cohort Study

Weimers, Petra; Halfvarson, Jonas; Sachs, Michael; Saunders‐Pullman, Rachel; Ludvigsson, Jonas F.; Peter, Inga; Burisch, Johan; Olén, Ola

doi:10.1093/ibd/izy190

Cited by 129 publications

(134 citation statements)

References 38 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…In a recently published article by our group, we too demonstrated a positive association between PD and IBD 6. We observed that Swedish patients with IBD were at 30% higher risk of subsequently developing PD than were non-IBD individuals.…”

supporting

confidence: 51%

Association between inflammatory bowel disease and Parkinson’s disease: seek and you shall find?

Weimers

Halfvarson

Sachs

et al. 2018

Gut

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 51%

Association between inflammatory bowel disease and Parkinson’s disease: seek and you shall find?

Weimers

Halfvarson

Sachs

et al. 2018

Gut

Self Cite

View full text Add to dashboard Cite

“…This hypothesis is supported by the observation that truncal vagotomy is associated with a lower risk of PD . Also, several gastrointestinal disorders, such as constipation, irritable bowel syndrome (IBS), and inflammatory bowel disease are associated with a higher risk of PD. Lewy‐type pathology has been detected in the gastrointestinal tract up to 20 years prior to PD diagnosis, and prominent denervation of the gut in prodromal and established PD has been demonstrated …”

mentioning

confidence: 89%

Antibiotic Exposure and Risk of Parkinson's Disease in Finland: A Nationwide Case‐Control Study

2019

View full text Add to dashboard Cite

Background Gut microbiota alterations have been found in prodromal and established Parkinson's disease (PD). Antibiotic exposure can have long‐term effects on the composition of human intestinal microbiota, but a potential connection between antibiotic exposure and risk of PD has not been studied previously. Objective To evaluate the impact of antibiotic exposure on the risk of PD in a nationwide, register‐based, case‐control study. Methods We identified all patients who were diagnosed with PD in Finland during the years 1998 to 2014. Information was obtained on individual purchases of orally administered antibiotics during the years 1993 to 2014. We assessed the association between prior antibiotic exposure and PD using conditional logistic regression. Results The study population consisted of 13,976 PD cases and 40,697 controls. The strongest connection with PD risk was found for oral exposure to macrolides and lincosamides (adjusted odds ratio up to 1.416; 95% confidence interval, 1.053–1.904). After correction for multiple comparisons, exposure to antianaerobics and tetracyclines 10 to 15 years before the index date, sulfonamides and trimethoprim 1 to 5 years before the index date, and antifungal medications 1 to 5 years before the index date were positively associated with PD risk. In post hoc analyses, further positive associations were found for broad‐spectrum antibiotics. Conclusions Exposure to certain types of oral antibiotics seems to be associated with an elevated risk of PD with a delay that is consistent with the proposed duration of a prodromal period. The pattern of associations supports the hypothesis that effects on gut microbiota could link antibiotics to PD, but further studies are needed to confirm this. © 2019 International Parkinson and Movement Disorder Society

show abstract

“…7. Inflammatory bowel disease (IBD) has been associated with increased PD risk 57,58 ; however, potential biases of analyses such as surveillance bias 59 require further investigation of IBD as a PD risk marker. In addition to IBD, inflammatory markers as well as (microbial) gut function in prodromal PD may constitute promising markers and avenues of prodromal PD research.…”

Section: Promising Candidate Markersmentioning

confidence: 99%

Update of the MDS research criteria for prodromal Parkinson's disease

et al. 2019

View full text Add to dashboard Cite

The MDS Research Criteria for Prodromal PD allow the diagnosis of prodromal Parkinson's disease using an evidence‐based conceptual framework, which was designed to be updated as new evidence becomes available. New prospective evidence of predictive values of risk and prodromal markers published since 2015 was reviewed and integrated into the criteria. Many of the predictive values (likelihood ratios, LR) remain unchanged. The positive likelihood ratio notably increase for olfactory loss and decreased for substantia nigra hyperechogenicity. Negative likelihood ratio remained largely unchanged for all markers. New levels of diagnostic certainty for neurogenic and symptomatic orthostatic hypotension have been added, which substantially differ in positive likelihood ratio from the original publication. For intermediate strength genetic variants, their age‐related penetrance is now incorporated in the calculation of the positive likelihood ratio. Moreover, apart from prospective studies, evidence from cross‐sectional case‐control genome‐wide association studies is also considered (given their likely lack of confounding and reverse causation), and to account for the effect of multiple low‐penetrance genetic variants polygenic risk scores are added to the model. Diabetes, global cognitive deficit, physical inactivity, and low plasma urate levels in men enter the criteria as new markers. A web‐based prodromal PD risk calculator allows the calculation of probabilities of prodromal PD for individuals. Several promising candidate markers may improve the diagnostic accuracy of prodromal PD in the future. © 2019 International Parkinson and Movement Disorder Society

show abstract

Inflammatory Bowel Disease and Parkinson’s Disease: A Nationwide Swedish Cohort Study

Abstract: IBD is associated with an increased risk of PD, but some of this association might be explained by surveillance bias. 10.1093/ibd/izy190_video1izy190.video15785623138001.

Cited by 129 publications

References 38 publications

Association between inflammatory bowel disease and Parkinson’s disease: seek and you shall find?

Association between inflammatory bowel disease and Parkinson’s disease: seek and you shall find?

Antibiotic Exposure and Risk of Parkinson's Disease in Finland: A Nationwide Case‐Control Study

Update of the MDS research criteria for prodromal Parkinson's disease

Contact Info

Product

Resources

About