Inflammatory Bowel Disease and Neutrophil–Lymphocyte Ratio: A Systematic Scoping Review

Langley, Blake O.; Guedry, Sara E.; Goldenberg, Joshua Z.; Hanes, David A.; Beardsley, Jennifer; Ryan, Jennifer

doi:10.3390/jcm10184219

Cited by 31 publications

(27 citation statements)

References 112 publications

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“…Assessment of NLR is non-invasive, low cost, and is easily calculated from blood count data routinely. The higher NLR values were associated with higher clinical disease activity, in patients with both CD and UC [149]. However, in assessing endoscopic activity, NLRs were not as useful in CD patients as in UC patients [150][151][152].…”

Section: Evaluation Of Disease Activity By Combined Biomarkersmentioning

confidence: 99%

Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease

Wagatsuma

Yokoyama

Nakase

2021

Life

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The number of patients with inflammatory bowel disease (IBD) is increasing worldwide. Endoscopy is the gold standard to assess the condition of IBD. The problem with this procedure is that the burden and cost on the patient are high. Therefore, the identification of a reliable biomarker to replace endoscopy is desired. Biomarkers are used in various situations such as diagnosis of IBD, evaluation of disease activity, prediction of therapeutic effect, and prediction of relapse. C-reactive protein and fecal calprotectin have a lot of evidence as objective biomarkers of disease activity in IBD. The usefulness of the fecal immunochemical test, serum leucine-rich glycoprotein, and urinary prostaglandin E major metabolite have also been reported. Herein, we comprehensively review the usefulness and limitations of biomarkers that can be used in daily clinical practice regarding IBD. To date, no biomarker is sufficiently accurate to replace endoscopy; however, it is important to understand the characteristics of each biomarker and use the appropriate biomarker at the right time in daily clinical practice.

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Section: Evaluation Of Disease Activity By Combined Biomarkersmentioning

confidence: 99%

Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease

Wagatsuma

Yokoyama

Nakase

2021

Life

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“…Apart from that, NLR assessment may play a substantial role in the case of acute limb ischemia in terms of forecasting survival and the risk of amputation [ 22 ]. Strictly intertwined with inflammatory processes, the progression and postoperative complications of several malignancies as well as the clinical outcome of inflammatory diseases, such as systemic lupus erythematosus (SLE) or inflammatory bowel disease (IBD), could be predicted by the levels of GFAP [ 23 ], RDW [ 24 ], and NLR [ 25 , 26 , 27 ]. The prognostic significance of BNP and NLR is also evident in individuals presented with congestive heart failure [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Stroke and Emerging Blood Biomarkers: A Clinical Prospective

Gkantzios

Tsiptsios

Karatzetzou

et al. 2022

Neurology International

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Stroke constitutes the primary source of adult functional disability, exhibiting a paramount socioeconomic burden. Thus, it is of great importance that the prediction of stroke outcome be both prompt and accurate. Although modern neuroimaging and neurophysiological techniques are accessible, easily available blood biomarkers reflecting underlying stroke-related pathophysiological processes, including glial and/or neuronal death, neuroendocrine responses, inflammation, increased oxidative stress, blood–brain barrier disruption, endothelial dysfunction, and hemostasis, are required in order to facilitate stroke prognosis. A literature search of two databases (MEDLINE and Science Direct) was conducted in order to trace all relevant studies published between 1 January 2010 and 31 December 2021 that focused on the clinical utility of brain natriuretic peptide, glial fibrillary acidic protein, the red cell distribution width, the neutrophil-to-lymphocyte ratio, matrix metalloproteinase-9, and aquaporin-4 as prognostic tools in stroke survivors. Only full-text articles published in English were included. Twenty-eight articles were identified and are included in this review. All studied blood-derived biomarkers proved to be valuable prognostic tools poststroke, the clinical implementation of which may accurately predict the survivors’ functional outcomes, thus significantly enhancing the rehabilitation efficiency of stroke patients. Along with already utilized clinical, neurophysiological, and neuroimaging biomarkers, a blood-derived multi-biomarker panel is proposed as a reasonable approach to enhance the predictive power of stroke prognostic models.

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“…Some anti-inflammatory and anti-cytokine therapies have been studied to treat coronary heart disease ( 27 – 29 ). In healthy individuals, the NLR value is approximately 1.65–1.70 ( 9 ). Our result was 2.303 ± 1.278 in all 2,827 observers, higher than the literature reported.…”

Section: Discussionmentioning

confidence: 99%

The Core Role of Neutrophil–Lymphocyte Ratio to Predict All-Cause and Cardiovascular Mortality: A Research of the 2005–2014 National Health and Nutrition Examination Survey

Xia

Qing

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo further supplement the previous research on the relationship between neutrophil–lymphocyte ratio (NLR) and all-cause and cardiovascular mortality, and construct clinical models to predict mortality.MethodsA total number of 2,827 observers were included from the National Health and Nutrition Examination Survey (NHANES) database in our research. NLR was calculated from complete blood count. According to the quartile of baseline NLR, those observers were divided into four groups. A multivariate weighted Cox regression model was used to analyze the association of NLR with mortality. We constructed simple clinical prognosis models by nomograms. Kaplan–Meier survival curves were used to depict cause-specific mortality. Restricted cubic spline regression was used to make explicit relationships between NLR and mortality.ResultsThis study recruited 2,827 subjects aged ≥ 18 years from 2005 to 2014. The average age of these observers was 51.55 ± 17.62, and 57.69% were male. NLR is still an independent predictor, adjusted for age, gender, race, drinking, smoking, dyslipidemia, and other laboratory covariates. The area under the receiver operating characteristic curves (AUCs) of NLR for predicting all-cause mortality and cardiovascular mortality were 0.632(95% CI [0599, 0.664]) and 0.653(95% CI [0.581, 0.725]), respectively, which were superior to C-reactive protein (AUCs: 0.609 and 0.533) and WBC (AUCs: 0.522 and 0.513). The calibration and discrimination of the nomograms were validated by calibration plots and concordance index (C-index), and the C-indexes (95% CIs) of nomograms for all-cause and cardiovascular mortality were 0.839[0.819,0.859] and 0.877[0.844,0.910], respectively. The restricted cubic spline showed a non-linear relationship between NLR and mortality. NLR > 2.053 might be a risk factor for mortality.ConclusionThere is a non-linear relationship between NLR and mortality. NLR is an independent factor related to mortality, and NLR > 2.053 will be a risk factor for prognosis. NLR and nomogram should be promoted to medical use for practicality and convenience.

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Inflammatory Bowel Disease and Neutrophil–Lymphocyte Ratio: A Systematic Scoping Review

Cited by 31 publications

References 112 publications

Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease

Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease

Stroke and Emerging Blood Biomarkers: A Clinical Prospective

The Core Role of Neutrophil–Lymphocyte Ratio to Predict All-Cause and Cardiovascular Mortality: A Research of the 2005–2014 National Health and Nutrition Examination Survey

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