Inflammatory bowel disease and isotretinoin

Brodin, Michael B.

doi:10.1016/s0190-9622(86)80535-7

Cited by 28 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies have indicated that excessive intake of retinoids can have inhibitory effects on both osteoblast and osteoclast activity that may pose a theoretical risk for fractures or hyperostosis. [99][100][101][102][103][104][105][106][107][108][109][110][111][112] Well-designed clinical studies involving human subjects have generated conflicting data on the association between excessive intake of vitamin A with the incidence of fractures. In evaluating isotretinoin specifically, 1 small prospective cohort study associated isotretinoin with minimal-to-mild bone demineralization at specific sites (such as Ward' s triangle of the femur), but revealed that these effects may be reversible.…”

Section: Bone Effectsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

View full text Add to dashboard Cite

INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

show abstract

Section: Bone Effectsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The first detailed report of an association of oral isotretinoin therapy with IBD was published by Brodin in 1986, and concerned the development of proctitis shortly after commencement of isotretinoin therapy in a 26-year-old woman 4. Martin et al 5 then reported a second case of proctosigmoiditis that developed in a 17-year-old patient within days of starting isotretinoin and provided more compelling evidence of a link between the drug and colitis, because withdrawal of the drug resulted in reduced severity of inflammation, which recurred after a rechallenge with the drug.…”

Section: Clinical Experiencementioning

confidence: 99%

“…Intriguing and less appreciated is the potential association of IBD with the use of the vitamin A analogue isotretinoin (13- cis -retinoic acid) which is widely prescribed in the treatment of severe acne. A small number of case reports have reported the development of IBD whilst receiving isotretinoin therapy 4 – 11. A review of adverse events reported to the United States Federal Drug Administration’s (FDA) Medwatch scheme over a 5 year period (1997–2002) revealed 85 cases of IBD, of which the causal association with isotretinoin was considered probable or highly probable in 73% of cases 12.…”

mentioning

confidence: 99%

Isotretinoin and intestinal inflammation: what gastroenterologists need to know

Shale

Kaplan

Panaccione

et al. 2009

Gut

View full text Add to dashboard Cite

“…Although there are reports of successful Isotretinoin therapy in patients with a history of IBD, 5,6 other authors have reported cases of IBD presenting after initiation of therapy with Isotretinoin, or exacerbations of colitis after treatment with Isotretinoin. 4,[7][8][9] This case suggests that Isotretinoin may also cause an acute pan-enteritis. Given the negative family history for IBD and the strong temporal relationship between the onset of symptoms and the introduction of Isotretinoin, it is likely that Isotretinoin was the cause of the enteropathy in this patient (according to the Naranjo probability scale).…”

Section: Discussionmentioning

confidence: 81%

Isotretinoin-associated Pan-enteritis

Spada

Riccioni

Marchese

et al. 2008

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

A 22-year-old man has been recently admitted to our Department with a 10-day history of melena. Because of nodular acne, the patient had been treated with Isotretinoin, a 13-cis-retinoic acid (20-mg twice daily, for 15 d). Upper gastrointestinal endoscopy revealed edema and hyperemia of the gastric mucosa of the body and antrum. Flexible sigmoidoscopy revealed edema and hyperemia of the mucosa of the rectum and sigmoid colon with numerous erosions. To exclude the possibility of small bowel involvement the patient underwent video capsule endoscopy that showed a diffuse and extensive intestinal inflammation with multiple linear, irregular-shaped jejunal ulcerations, and apthae. Isotretinoin was discontinued and the patient improved with complete resolution of symptoms.

show abstract

Inflammatory bowel disease and isotretinoin

Cited by 28 publications

References 0 publications

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Isotretinoin and intestinal inflammation: what gastroenterologists need to know

Isotretinoin-associated Pan-enteritis

Contact Info

Product

Resources

About