Inflammatory bowel disease and immune-mediated inflammatory diseases: looking at the less frequent associations

Abstract

Patients with inflammatory bowel disease (IBD) often have other immune-mediated inflammatory diseases (IMIDs), and the prevalence of any IMID is higher in IBD patients than in the general population. IBD and other IMIDs involve alterations in innate and adaptive immune responses. Their co-occurrence depends on shared immune and inflammatory processes, pathogenic mechanisms, and genetic and environmental risk factors, including drugs, especially tumor necrosis factor inhibitors. The more common IMIDs associated with IBD have been widely described, so this review focuses on the less frequent associations. The IMIDs discussed here are skin disorders (psoriasis, atopic dermatitis, vitiligo, epidermolysis bullosa acquisita, cutaneous polyarteritis nodosa, and hidradenitis suppurativa), hepato-pancreatic diseases (autoimmune hepatitis, granulomatous hepatitis, and autoimmune pancreatitis), endocrine diseases (autoimmune thyroid diseases, and type 1 diabetes mellitus), multiple sclerosis, and respiratory diseases (asthma, bronchiectasis, and interstitial pneumonia). The early detection of IMIDs in IBD patients is important to prevent their deleterious clinical course and limit their psychological impact. Care for IBD patients with IMIDs should be multispecialist, with a single therapeutic strategy instead of treating each disease separately.

Autoimmune pancreatitis associated with inflammatory bowel diseases: A retrospectively bidirectional case–control study in China

“…Autoimmune pancreatitis (AIP), first named by Yoshida et al in 1995, 3 is a immune-mediated inflammatory disease that is clinically characterized by obstructive jaundice, histologically characterized by dense lymphoplasmacytic infiltration and fibrosis, and therapeutically characterized by a dramatic response to corticosteroid therapy. 4 AIP can be classified based on histological and clinical profiling into two subtypes, ie, lymphoplasmacytic sclerosing pancreatitis (type 1 AIP) and idiopathic duct-centric pancreatitis (type 2 AIP). 5,6 Type 1 AIP is the pancreatic manifestation of systemic immunoglobulin G4 (IgG4) disease and occurs mostly in men in their 70s, while type 2 AIP is frequently seen in younger patients in their 50s and is often associated with IBD.…”

Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics

“…12,13 The common pathogeneses of UC and psoriasis are lifestyle factors, genetic overlap, gut microbial antigens, and shared immune and inflammatory processes. 14,15 Many treatments for psoriasis are also suitable for UC, such as infliximab 16 and ustekinumab. 17 Some studies have shown the opinion that inflammatory bowel disease (IBD) and psoriasis are both related to the immune response, which alter the microbiota of gut and skin after environmental triggers for genetically susceptible individuals.…”

“…A nationwide population‐based matched cohort study in Korea showed that UC patients had an increased risk of psoriasis, with an incidence of 217.68 per 100 000 person‐years 12,13 . The common pathogeneses of UC and psoriasis are lifestyle factors, genetic overlap, gut microbial antigens, and shared immune and inflammatory processes 14,15 . Many treatments for psoriasis are also suitable for UC, such as infliximab 16 and ustekinumab 17 .…”

Inflammatory bowel disease and Pancreatitis: A Two-Sample Mendelian Randomization Study

“…In recent years, there are increasing reports on the association between IBD and pancreatitis, but few has been mentioned about the causal relationship between the two [10][11][12][13][14][15]. IBD patients often have other immune-mediated in ammatory diseases, including autoimmune pancreatitis [10]. Autoimmune pancreatitis is more common in patients with IBD than in the general population [10,16,17].…”

“…IBD patients often have other immune-mediated in ammatory diseases, including autoimmune pancreatitis [10]. Autoimmune pancreatitis is more common in patients with IBD than in the general population [10,16,17]. IBD and AIPrelated AP were accepted by the general public, but the pathophysiology of IBD and AP/CP is still controversial.…”