Inflammatory Bowel Disease and Customized Nutritional Intervention Focusing on Gut Microbiome Balance

Fiorindi, Camilla; Russo, Edda; Balocchini, Lucrezia; Amedei, Amedeo; Giudici, Francesco

doi:10.3390/nu14194117

Cited by 7 publications

(4 citation statements)

References 154 publications

(173 reference statements)

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“…The reluctance to consume fruit, vegetables and legumes observed in patients with IBD, caused by the fear of symptom exacerbation and the hope of sustaining remission, contributes to nutritional deficiencies, as shown in studies [64][65][66][67]. This undoubtedly has an impact on the shift away from the Mediterranean pattern observed over the past decade or so, even in the Mediterranean populations.…”

Section: Discussionmentioning

confidence: 99%

Habitual Dietary Intake and Adherence to Dietary Guidelines of Patients with Inflammatory Bowel Diseases

Godala,

Gaszyńska,

Walczak

et al. 2024

Gastroenterology Insights

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Inflammatory bowel disease (IBD) belongs to a group of autoimmune conditions characterized by chronic inflammation and mucosal ulceration of the gastrointestinal tract. The etiology of IBD is complex. The etiological factors include environmental factors, among which diet is important. The aim of this study was to evaluate the diet of IBD patients. This case–control study was carried out on 82 patients with IBD; the control group consisted of 80 clinically healthy subjects. Food intake was assessed using a 24 h recall and frequency food questionnaire. Energy intake in the IBD group was insufficient and significantly lower than in the control group. The energy intake in the group of patients with active IBD was significantly lower than in the group of subjects in remission. The total fat and protein intake was significantly lower in the IBD group compared to the healthy subjects. IBD patients were characterized by underconsumption of all food groups analyzed, except for the intake of red meat and poultry. Our study showed inadequate intake of energy and most nutrients in IBD patients, even during the remission period. The study indicates the need for routine assessment of dietary intake and nutrition among IBD patients, as well as potential dietary interventions aimed at improving the energy and nutritional quality of diet in order to optimize treatment outcomes and prevent the development of accompanying diseases.

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Section: Discussionmentioning

confidence: 99%

Habitual Dietary Intake and Adherence to Dietary Guidelines of Patients with Inflammatory Bowel Diseases

Godala,

Gaszyńska,

Walczak

et al. 2024

Gastroenterology Insights

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“…It is vital to note that the prohealthy diet index was higher among healthy subjects than the CD and UC groups. It is reasonable to assume that products associated with a higher prohealthy index – such as wholemeal bread, milk, legumes, fruits and vegetables – are usually avoided by IBD patients because their large consumption may worsen the gastrointestinal symptoms 32 . Moreover, Dolovich et al reported that a moderate health diet score was weakly associated with active inflammation; however, moderate health diet score was linked to symptoms of IBD.…”

Section: Discussionmentioning

confidence: 99%

“…It is reasonable to assume that products associated with a higher prohealthy indexsuch as wholemeal bread, milk, legumes, fruits and vegetablesare usually avoided by IBD patients because their large consumption may worsen the gastrointestinal symptoms. 32 Moreover, Dolovich et al reported that a moderate health diet score was weakly associated with active inflammation; however, moderate health diet score was linked to symptoms of IBD. Authors suggested it was caused by the intake of fruits and vegetables, which may influence the gastrointestinal tract of IBD patients.…”

Section: Discussionmentioning

confidence: 99%

Physical activity, quality of diet and bone mineral density in patients with inflammatory bowel disease

Ratajczak

Michalak

Szymczak-Tomczak

et al. 2023

J Human Nutrition Diet

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BackgroundThe aim of this study was to find an association between moderate, vigorous and total physical activity (PA); diet quality; and bone mineral density (BMD) among patients suffering from inflammatory bowel disease (IBD).MethodsWe enrolled 54 IBD patients, including those with Crohn's disease (CD) and ulcerative colitis (UC), and 24 healthy adults. All subjects completed the Questionnaire of Eating Behaviour based on which prohealthy and nonhealthy diet indexes were calculated, and the questionnaire included questions from the International Physical Activity Questionnaire. Prohealthy and nonhealthy diet indexes were divided into low‐, medium‐ and high scores. BMD and T‐ and Z‐scores of the lumbar spine (L1–L4) and femoral neck (FN) were assessed using dual‐energy X‐ray absorptiometry method.ResultsBMD, T‐ and Z‐scores of the FN and the Z‐score of L1–L4 were significantly lower among patients with CD and UC than healthy controls. We did not find any differences in the time of PA among CD, UC and control groups (CG). The prohealthy diet index was higher among healthy subjects than the CD and UC groups. The nonhealthy diet index was lower among UC patients compared with the CG or CD patients. Prohealthy diet index positively correlated with BMD and T‐ and Z‐scores of L1–L4 and FN in IBD. The prohealthy diet index correlated negatively with C‐reactive protein and positively with body mass index. The prohealthy diet index correlated only with total PA in the CD group.ConclusionA well‐balanced diet and proper PA may decrease the risk of osteoporosis in IBD, so education of patients referring to nutrition and PA is needed.

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“…Crohn’s disease (CD), one of the main phenotypes of inflammatory bowel disease (IBD), can affect any part of the gastrointestinal tract ( Fiorindi et al, 2022 ; Godala et al, 2022 ). It can impact the function of gastrointestinal secretions, as well as increasing the intestinal permeability leading to an aberrant immunological response and subsequent intestinal inflammation ( Chichlowski and Hale, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Structural brain morphometry differences and similarities between young patients with Crohn’s disease in remission and healthy young and old controls

Yeske,

Hou,

Chu

et al. 2024

Front. Neurosci.

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IntroductionCrohn’s disease (CD), one of the main phenotypes of inflammatory bowel disease (IBD), can affect any part of the gastrointestinal tract. It can impact the function of gastrointestinal secretions, as well as increasing the intestinal permeability leading to an aberrant immunological response and subsequent intestinal inflammation. Studies have reported anatomical and functional brain changes in Crohn’s Disease patients (CDs), possibly due to increased inflammatory markers and microglial cells that play key roles in communicating between the brain, gut, and systemic immune system. To date, no studies have demonstrated similarities between morphological brain changes seen in IBD and brain morphometry observed in older healthy controls..MethodsFor the present study, twelve young CDs in remission (M = 26.08 years, SD = 4.9 years, 7 male) were recruited from an IBD Clinic. Data from 12 young age-matched healthy controls (HCs) (24.5 years, SD = 3.6 years, 8 male) and 12 older HCs (59 years, SD = 8 years, 8 male), previously collected for a different study under a similar MR protocol, were analyzed as controls. T1 weighted images and structural image processing techniques were used to extract surface-based brain measures, to test our hypothesis that young CDs have different brain surface morphometry than their age-matched young HCs and furthermore, appear more similar to older HCs. The phonemic verbal fluency (VF) task (the Controlled Oral Word Association Test, COWAT) (Benton, 1976) was administered to test verbal cognitive ability and executive control.Results/DiscussionOn the whole, CDs had more brain regions with differences in brain morphometry measures when compared to the young HCs as compared to the old HCs, suggesting that CD has an effect on the brain that makes it appear more similar to old HCs. Additionally, our study demonstrates this atypical brain morphometry is associated with function on a cognitive task. These results suggest that even younger CDs may be showing some evidence of structural brain changes that demonstrate increased resemblance to older HC brains rather than their similarly aged healthy counterparts.

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Inflammatory Bowel Disease and Customized Nutritional Intervention Focusing on Gut Microbiome Balance

Cited by 7 publications

References 154 publications

Habitual Dietary Intake and Adherence to Dietary Guidelines of Patients with Inflammatory Bowel Diseases

Habitual Dietary Intake and Adherence to Dietary Guidelines of Patients with Inflammatory Bowel Diseases

Physical activity, quality of diet and bone mineral density in patients with inflammatory bowel disease

Structural brain morphometry differences and similarities between young patients with Crohn’s disease in remission and healthy young and old controls

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