Inflammatory bowel disease: an overview of Chinese herbal medicine formula-based treatment

Abstract

Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the intestine, including Crohn’s disease (CD) and ulcerative colitis (UC), whose etiology and pathogenesis have not been fully understood. Due to its prolonged course and chronic recurrence, IBD imposes a heavy economic burden and psychological stress on patients. Traditional Chinese Herbal Medicine has unique advantages in IBD treatment because of its symptomatic treatment. However, the advantages of the Chinese Herbal Medicine Formula (CHMF) have rarely been discussed. In recent years, many scholars have conducted fundamental studies on CHMF to delay IBD from different perspectives and found that CHMF may help maintain intestinal integrity, reduce inflammation, and decrease oxidative stress, thus playing a positive role in the treatment of IBD. Therefore, this review focuses on the mechanisms associated with CHMF in IBD treatment. CHMF has apparent advantages. In addition to the exact composition and controlled quality of modern drugs, it also has multi-component and multi-target synergistic effects. CHMF has good prospects in the treatment of IBD, but its multi-agent composition and wide range of targets exacerbate the difficulty of studying its treatment of IBD. Future research on CHMF-related mechanisms is needed to achieve better efficacy.

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers

“…From a medical point of view, the use of herbal medicine is mainly based on a variety of herbs, and the efficacy of different herbs varies. Targeting the diseased area, multiple herbs can work simultaneously to achieve the purpose of treatment or improvement [ 42 ]. Although single herbs have made good progress in broiler farming, the advantages of mixed herbs are still noteworthy.…”

Reporting of Integrative Chinese and western medicine intervention in randomized controlled trials of ulcerative colitis: a scoping review

“…The results of adherence to the CONSORT, the CONSORT for Abstract, and ICWM-speci c checklist items are presented in The reporting score of the ICWM-speci c items was 13 (11)(12)(13)(14)(15). Four items were "excellent" (Q13, Q15, Q16, Q23), and "good" reporting in 5 items (Q1, Q5, Q6, Q14, Q17).…”

“…CM treatment mainly includes Chinese herbal formula (oral or rectal), acupuncture and moxibustion. Due to its multi-targeted mode of action, CM has unique advantages for treating in ammatory bowel diseases, including maintain intestinal integrity, reduce in ammation, and decrease oxidative stress, with minor side effects 14 . With the extensive studies on UC in recent years, it is con rmed that both CM and WM have unique advantages in UC management.…”

“…Speci cally, the reporting quality was excellent (> 90%) in 8 items (2a, 6b, 11b, 12b, 14b, 15, 18, and 22); good (65-90%) in 4 items (4b, 5, 13a and 16); and poor (< 65%) in 25 items (1a, 2b, 3a, 3b, 4a, 6a, 7a, 7b, 8a, 8b, 9, 10, 11a, 12a, 13b, 14a, 17a, 17b,19, 20, 21, 23, 24 and 25). For the CONSORT for Abstract, the reporting score was 18(14)(15)(16)(17)(18)(19)(20)(21). The quality of reporting was excellent (> 90%) in 3 items(3, 6 and 15); good (65-90%) in 1 item(10); and poor (< 65%) in 13 items(1, 2, 4, 5, 7, 8, 9, 11, 12, 13, 14, 16 and 17).…”

Novel ginsenoside monomer RT4 promotes colitis repair in mice by regulating miR‐144‐3p/SLC7A11 signaling pathway

“…It is crucial to develop a new medication that is both effective and safe for treating inflammatory bowel disease. As the use of herbal medicines and supplements for inflammatory bowel disease becomes more widespread, it is important to gain a comprehensive understanding of the underlying mechanisms for treating this disease [2]. Dextran sodium sulfate (DSS)‐induced colitis is often used in experimental studies because it mimics real inflammatory bowel disease.…”