Inflammatory bowel disease: A controlled study of late pregnancy outcome

Fedorkow, Donna M.; Persaud, D. David; Nimrod, Carl

doi:10.1016/0002-9378(89)90324-4

Cited by 123 publications

(58 citation statements)

References 5 publications

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“…Recent US data from a large prospective study as yet reported in abstract only (the PIANO study) are in general in keeping with our findings that thiopurines are not associated with increased congenital included only five studies with 702 pregnancies in total, which reduced to only 539 once the three smallest studies 30,33,35 (<100 pregnancies in women with IBD) had been excluded. The estimates from the meta-analysis are therefore driven by three studies 29,35,36 , but these among them studied only about one third of the pregnancies exposed to IBD presented in our current paper and half the number reported in the PIANO study .…”

Section: Interpretation In the Context Of Previous Literaturesupporting

confidence: 86%

Limited Risks of Major Congenital Anomalies in Children of Mothers With IBD and Effects of Medications

et al. 2014

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Section: Interpretation In the Context Of Previous Literaturesupporting

confidence: 86%

Limited Risks of Major Congenital Anomalies in Children of Mothers With IBD and Effects of Medications

et al. 2014

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“…Complications associated with IBD activity at the time of conception include: Abortion, low birth weight (LBW), and premature births [50,[52][53][54][55] . These complications again, are usually seen more often in CD patients than UC patients.…”

Section: Pregnancymentioning

confidence: 99%

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Hosseini‐Carroll¹,

Mutyala²,

Seth³

et al. 2015

WJGPT

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Manas K made critical revisions of the manuscript; Becker F and Alexander JS contributed equally as senior authors. Conflict-of-interest statement:There are no known conflicts of interest. The authors (Pegah Hosseini-Carroll, Monica Mutyala, Abhishek Seth, Shaheen Nageeb, Demiana Soliman, Moheb Boktor, Ankur Sheth, Jonathon Chapman, James Morris, Paul Jordan, Kenneth Manas, Felix Becker, and J Steven Alexander) have no relevant financial considerations related to this proposal, and the study was not supported by any corporate entity. There is no known intellectual property associated with this report. AbstractInflammatory bowel diseases (IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them (both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care (particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy during 157November 6, 2015|Volume 6|Issue 4| WJGPT|www.wjgnet.com Hosseini-Carroll P et al . Pregnancy and inflammatory bowel diseases IBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become, (or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception (in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. Core tip: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions characterized by relapsing and remitting episodes of intestinal inflammation. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While therapies have improved dramatically, IBDs have important effects on pregnancy and present challenges for maintaining optimal outcomes for mothers and their developing fetus/ neonate. Women with IBD and physician...

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“…Earlier studies showed active disease at conception was associated with a higher rate of fetal loss [52] and preterm birth [9,28]. Disease activity during pregnancy has also previously been associated with preterm birth and low birthweight [37,46,53,54]. Secondary analysis conducted by Stephansson et al attempted to correlate pregnancy outcomes with disease activity, specifically looking at women who had ever been hospitalized for UC compared with those with outpatient management only [40].…”

Section: Effect Of Ibd On Pregnancy Course and Pregnancy Outcomesmentioning

confidence: 99%

Management of inflammatory bowel disease in pregnancy

Ng¹,

2013

Expert Review of Clinical Immunology

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Inflammatory bowel disease: A controlled study of late pregnancy outcome

Cited by 123 publications

References 5 publications

Limited Risks of Major Congenital Anomalies in Children of Mothers With IBD and Effects of Medications

Limited Risks of Major Congenital Anomalies in Children of Mothers With IBD and Effects of Medications

Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

Management of inflammatory bowel disease in pregnancy

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