Inflammatory Bowel Disease

Taylor, Kent D.; Yang, Huiying; Rotter, Jerome I.

doi:10.1006/mgme.2001.3214

Cited by 16 publications

(6 citation statements)

References 133 publications

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“…Various immune and inflammatory cells, such as lymphocytes, macrophages, and dendritic cells, play important roles in the development and progression of IBD [6][7][8]. Based on the clinical features and histopathology, IBD is classified into two major entities, ulcerative colitis (UC) and Crohn's disease (CD) [4,5].…”

Section: Introductionmentioning

confidence: 99%

Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease

et al. 2009

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“…Some genome-wide linkage analyses and candidate gene-based association studies with single nucleotide polymorphisms (SNPs), which focus on determining unknown genetic factors underlying the genetic determinants of the pathogenesis of IBD, have identified possible IBD-susceptibility genes and chromosomal loci [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of PTPN11 Coding SHP-2 as Biomarkers for Ulcerative Colitis Susceptibility in the Japanese Population

et al. 2009

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Objective To identify genetic determinants of inflammatory bowel disease (IBD), we examined an association between polymorphisms of both the Subsequently, haplotypes composed of the two SNPs in PTPN11 were constructed. Results The frequencies of the Hap 1 haplotype and itsNarumi et al. 5homozygous Hap 1/Hap 1 diplotype of PTPN11 were significantly increased in UC patients compared to control subjects (P = 0.011 and P = 0.030, respectively). While, no association was found for PDCD1 for UC or CD and none for PTPN11 for CD.Conclusion PTPN11 is a genetic determinant for the pathogenesis of UC, and haplotyping of PTPN11 may be useful as a genetic biomarker to identify high-risk individuals susceptible to UC.

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“…Various immune and inflammatory cells, such as lymphocytes, macrophages, and dendritic cells, play important roles in the development and progression of IBD (3)(4)(5). In addition, bacterial antigens have been implied in the pathological inflammation and may mediate both innate and adaptive responses underlying chronic inflammation (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population

Chen

Isomoto

Narumi

et al. 2008

Clinical Immunology

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Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder characterized by intractable inflammation specific to the gastrointestinal tract. The precise etiology of IBD remains unknown. Recently, haplotypes of peptidylarginine deiminase type 4 (PADI4) have been identified as the rheumatoid arthritis (RA)-susceptible gene. PADI4 is located at 1p36, which is one of chromosomal loci susceptible for IBD. Then, we examined whether haplotypes and diplotypes of PADI4 are associated with IBD in the Japanese population. We studied haplotypes of PADI4 in 114 patients with UC, 83 patients with CD, and 200 gender-matched healthy controls by PCR-restriction fragment length polymorphism. Frequencies and distributions of haplotypes and diplotypes were compared statistically between patients and controls by logistic regression analysis. The frequency of haplotype 1 was significantly decreased in patients with UC, compared to that in controls (P = 0.037; odds ratio (OR) = 0.702). In contrast, the frequency of haplotype 2 in patients with UC was significantly higher than that in controls (P = 0.003; OR = 1.722). Moreover, of a total of 114 patients with UC, 15 (13.2%) had a diplotype homozygous for haplotype 2, the frequency being significantly higher than in controls (9/200, 4.5%; P = 0.008, OR = 3.215). Our results indicate that Czin 4 haplotype 1 of PADI4 is associated with non-susceptibility to UC, whereas haplotype 2 is susceptible to UC. Thus, it is likely that PADI4 is one of genetic determinants of UC in the Japanese population.

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Inflammatory Bowel Disease

Cited by 16 publications

References 133 publications

Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease

Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease

Polymorphisms of PTPN11 Coding SHP-2 as Biomarkers for Ulcerative Colitis Susceptibility in the Japanese Population

Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population

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