Inflammatory Blood Markers as Prognostic and Predictive Factors in Early Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Corbeau, Iléana; Thézenas, Simon; Maran-Gonzalez, Aurélie; Colombo, Pierre‐Emmanuel; Jacot, William; Guiu, Séverine

doi:10.3390/cancers12092666

Cited by 19 publications

(27 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As we showed that the ensemble of patients with pCR and small residual disease had better outcome than the rest of the patients, and that PLR was predictive of that type of response, we are hypothesizing that a prognostic value of PLR could be confirmed in a larger study. Corbeau et al demonstrated that higher PLR is associated to worse RFS and OS in 280 breast cancer patients, 72 of which were TNBC (52). One recent metaanalysis found that higher PLR was associated to worse disease-free and overall survival in all-type breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Corbeau et al. demonstrated that higher PLR is associated to worse RFS and OS in 280 breast cancer patients, 72 of which were TNBC ( 52 ). One recent meta-analysis found that higher PLR was associated to worse disease-free and overall survival in all-type breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 shows clinical characteristics of those patients and histological features of their tumors. The median follow-up was 46 months [IC 95% (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)]. The median age at diagnosis was 56 years (range: 28 to 86).…”

Section: Patient Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Platelet-to-Lymphocyte Ratio Is Associated With Favorable Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Study on 120 Patients

et al. 2021

View full text Add to dashboard Cite

IntroductionTriple negative breast cancer (TNBC) is highly heterogeneous, but still most of the patients are treated by the anthracycline/taxane-based neoadjuvant therapy (NACT). Tumor-infiltrating lymphocytes (TILs) are a strong predictive and prognostic biomarker in TNBC, however are not always available. Peripheral blood counts, which reflect the systemic inflammatory/immune status, are easier to obtain than TILs. We investigated whether baseline white cell or platelet counts, as well as, Neutrophil-to-Lymphocyte Ratio (NLR) or Platelet-to-Lymphocyte Ratio (PLR) could replace baseline TILs as predictive or prognostic biomarkers in a series of TNBC treated by standard NACT.Patients and MethodsOne hundred twenty patients uniformly treated by FEC/taxane NACT in a tertiary cancer care center were retrospectively analyzed. The presence of pathological complete response (pCR: ypT0/Tis, ypN0) or the presence of pCR and/small residual disease (ypT0/Tis/T1ab, ypN0) were considered as good responses in data analysis. Baseline/pre-NACT blood count, NLR, PLR and TILs were evaluated as predictors of response, distant recurrence rate and distant recurrence-free survival (DRFS).ResultsTILs ≥30% and ≥1.5% were best predictors of pCR and distant recurrence risk, respectively (p = 0.007, p = 0.012). However, in this cohort, pCR status was not significantly associated with recurrence. Only the ensemble of patients with pCR and small residual disease had lower recurrence risk and longer survival DRFS (p = 0.042, p = 0.024, respectively) than the rest of the cohort (larger residual disease). The only parameter which could predict the pCR/small residual disease status was PLR: patients with values lower than 133.25 had significantly higher chance of reaching that status after NACT (p = 0.045). However, no direct correlation could be established between baseline PLR and metastatic recurrence. No correlation either was found between TIL and individual blood counts, or between TILs and NLR or PLR.ConclusionIn this cohort, TILs retained their pCR predictive value; however PLR was a better predictor of the ensemble of responses which had good outcome in terms of less distant recurrences or longer DRFS (pCR or small residual disease). Thus, baseline PLR is worth further, prospective investigation together with baseline TILs, as it might indicate a good TNBC response to NACT when TILs are unavailable.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet-to-Lymphocyte Ratio Is Associated With Favorable Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Study on 120 Patients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Platelets and platelet-related markers, such as the platelet-to-lymphocyte ratio, are significant prognostic factors in patients with breast cancer. 81 , 82 Beili Wang and colleagues conducted a prospective study of 191 hepatocellular carcinoma (HCC) patients and 99 healthy subjects. 83 Flow cytometry was used to evaluate the platelet activation state by two platelet markers, PAC-1 and CD62p.…”

Section: Activated Platelets Can Participate In Tumour Formation and Progressionmentioning

confidence: 99%

Platelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies

Meng¹,

Sun²,

Yang³

et al. 2021

OTT

View full text Add to dashboard Cite

Due to the inherent molecular heterogeneity of metastatic tumours and the dynamic evolution ability of tumour genomes, tumour tissues obtained through biopsy and other methods cannot capture all of the features of tumour genomes. A new diagnostic concept called "liquid biopsy" has received widespread attention in recent years. Liquid biopsy has changed the clinical practice of oncology and is widely used to guide targeted drug utilization, monitor disease progression and track drug resistance. The latest research subject in liquid biopsy is platelets. Platelets originate from multifunctional haematopoietic stem cells in the bone marrow haematopoietic system. They are small cells from the cytoplasm of bone marrow megakaryocytes. Their main physiological functions are to participate in the processes of physiological haemostasis and coagulation. Tumour cells transfer biomolecules (such as RNA) to platelets through direct contact and release of exosomes, which changes the platelet precursor RNA. Under the stimulation of tumour cells and the tumour microenvironment, platelet precursor mRNA is spliced into mature RNA and converted into functional protein to respond to external stimuli, forming tumoureducated platelets (TEPs). The detection of TEPs in the peripheral blood of patients is expected to be used in clinical tumour diagnosis. This emerging liquid biopsy method can replace and supplement the current tumour detection methods. Further research on the role of platelets in tumour diagnosis will help provide a novel theoretical basis for clinical tumour diagnosis.

show abstract

“…Accumulating evidence suggests that the white blood cell (WBC) count and its subtypes, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR), are potential novel indicators of systemic in ammation in various diseases [12][13][14][15][16][17][18] . Interestingly, increasing evidence has shown that they are also prognostic factors for DM and related complications [19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

Zeng¹,

Chen²,

Qiu³

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction:Diabetic retinopathy (DR), as a serious and specific neurovascular complication of DM, remains the leading cause of vision loss and preventable blindness in adults aged 20–74 years. Several studies have indicated that chronic inflammation plays an important role in DR. Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are novel potential markers of inflammatory responses. However, only a few articles have evaluated the association between these factors and DR.Patients and Methods: The study included 133 patients diagnosed with type 2 diabetes mellitus (T2DM). Retinopathy was graded using the International Clinical Diabetic Retinopathy Disease Severity Scale.Results:The mean NLR, PLR and MLR were significantly higher in patients with DR than in patients without DR (p < 0.001, p = 0.002, and p = 0.003, respectively). In the post hoc analysis, the PDR group had the highest NLR and MLR values among the three groups. Multiple logistic regression showed that the PLR was an independent risk factor for DR (odds ratio [OR]: 1.022, 95% confidence interval [CI]: 1.005–1.040 p = 0.013). Based on the receiver operating characteristic (ROC) curve, the cutoff value of PLR as an indicator for DR diagnosis was projected to be 78.70 and yielded a sensitivity and specificity of 80.7% and 48.9%, respectively, with an area under the curve of 0.669 (95% CI: 0.572–0.765, P = 0.002).Conclusions:Our results suggest that PLR may be an independent risk factor for evaluating DR in patients with type 2 diabetes.

show abstract

Inflammatory Blood Markers as Prognostic and Predictive Factors in Early Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Cited by 19 publications

References 58 publications

Platelet-to-Lymphocyte Ratio Is Associated With Favorable Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Study on 120 Patients

Platelet-to-Lymphocyte Ratio Is Associated With Favorable Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Study on 120 Patients

Platelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies

The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About