Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia

Abstract

The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

“…There are few studies of circulating BDNF in patients with FM and they are not in agreement. This, and a previous study, found higher plasma levels of BDNF in FM, but another study found no difference (17,18). In addition, the results concerning serum levels of BDNF in FM are conflicting (19,47).…”

“…In FM, changes in fatigue after an exercise intervention correlated negatively with changes in NGF (33). No alterations in plasma levels of BDNF were found after whole-body vibration in FM (18).…”

“…There are only a few studies of circulating BDNF in FM and they are not in agreement. Higher plasma levels of BDNF in FM have been reported (17), but another study found no difference (18). Serum studies are also conflicting (19,20).…”

Whole-Body Vibration Exercise as an Intervention to Improve Musculoskeletal Performance

“…These findings can contribute to decrease the possibility of injury, as in the sports, in the improvement of the fitness and on the management of various diseases. WBV exercise can produce beneficial responses, including improvements in muscle strength in trained (athletes) and untrained individuals and in patients with several clinical conditions, such as, chronic obstructive pulmonary disease (COPD), Parkinson's disease (PD), metabolic syndrome (MetS), fibromyalgia (FM) and multiple sclerosis (MS) [11][12][13][14][15]. Moreover, improvements in the walking function, the bone mineral density (BMD) in elderly, the low back pain (LBP), health-related quality of life (QOL), fall risk, balance and gait have been described [1,7,[16][17][18][19][20].…”

“…It was concluded that vibration-based training could be a promising alternative or additional modality to active exercise-based fall prevention programs for people with obesity. Ribeiro et al [14] characterized the intensity of the WBV stimulation in women diagnosed with FM compared to a CG of healthy women (HW). It was investigated the effect of a single session of WBV intervention on inflammatory responses and the levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined.…”