Inflammatory Biomarkers Predict Airflow Obstruction After Exposure to World Trade Center Dust

Nolan, Anna; Naveed, Bushra; Comfort, Ashley L.; Ferrier, Natalia; Hall, Charles B.; Kwon, Sophia; Kasturiarachchi, Kusali J.; Cohen, Hillel W.; Zeig‐Owens, Rachel; Glaser, Michelle S.; Webber, Mayris P.; Aldrich, Thomas K.; Rom, William N.; Kelly, Kerry J.; Prezant, David J.; Weiden, Michael D.

doi:10.1378/chest.11-1202

Cited by 66 publications

(86 citation statements)

References 24 publications

(22 reference statements)

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“…Serum inflammatory biomarkers are also elevated in COPD exacerbations (49)(50)(51). We have recently reported that low a 1 -antitrypsin, elevated granulocyte-macrophage colonystimulating factor, and macrophage-derived chemokine are additional risk factors for the development of WTC-related lung injury (52)(53)(54). The contribution of the serum glucose became nonsignificant in the final model.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Naveed

Weiden

Kwon

et al. 2012

Am J Respir Crit Care Med

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113

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Rationale:Cross-sectional studies demonstrate an association between metabolic syndrome and impaired lung function. Objectives: To define if metabolic syndrome biomarkers are risk factors for loss of lung function after irritant exposure. Methods: A nested case-control study of Fire Department of New York personnel with normal pre-September 11th FEV 1 and who presented for subspecialty pulmonary evaluation before March 10, 2008. We correlated metabolic syndrome biomarkers obtained within 6 months of World Trade Center dust exposure with subsequent FEV 1 . FEV 1 at subspecialty pulmonary evaluation within 6.5 years defined disease status; cases had FEV 1 less than lower limit of normal, whereas control subjects had FEV 1 greater than or equal to lower limit of normal. Measurements and Main Results: Clinical data and serum sampled at the first monitoring examination within 6 months of September 11, 2001, assessed body mass index, heart rate, serum glucose, triglycerides and high-density lipoprotein (HDL), leptin, pancreatic polypeptide, and amylin. Cases and control subjects had significant differences in HDL less than 40 mg/dl with triglycerides greater than or equal to 150 mg/dl, heart rate greater than or equal to 66 bpm, and leptin greater than or equal to 10,300 pg/ml. Each increased the odds of abnormal FEV 1 at pulmonary evaluation by more than twofold, whereas amylin greater than or equal to 116 pg/ml decreased the odds by 84%, in a multibiomarker model adjusting for age, race, body mass index, and World Trade Center arrival time. This model had a sensitivity of 41%, a specificity of 86%, and a receiver operating characteristic area under the curve of 0.77. Conclusions: Abnormal triglycerides and HDL and elevated heart rate and leptin are independent risk factors of greater susceptibility to lung function impairment after September 11, 2001, whereas elevated amylin is protective. Metabolic biomarkers are predictors of lung disease, and may be useful for assessing risk of impaired lung function in response to particulate inhalation.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

Naveed

Weiden

Kwon

et al. 2012

Am J Respir Crit Care Med

Self Cite

113

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“…In addition to medical monitoring, the World Trade Center Health Program also pays for treatment of a wide variety of health conditions provided that a program physician determines that 9/11-related exposures were a significant factor in causing or exacerbating the condition. Numerous studies have been published in the peer-reviewed medical literature using data collected by the World Trade Center Health Program and related World Trade Center Health Registry [26][27][28][29][30][31][32][33][34][35][36][37][38]. As with the FMMP, the World Trade Center Health Program is an extensive program, which may be more reflective of American sentiments towards World Trade Center responders than strict scientific principles, with funding in excess of $1 billion.…”

Section: World Trade Center Health Programmentioning

confidence: 99%

The implementation of medical monitoring programs following potentially hazardous exposures: a medico-legal perspective

Vearrier

Greenberg

2017

Clinical Toxicology

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Context: Clinical toxicologists may be called upon to determine the appropriateness of medical monitoring following documented or purported exposures to toxicants in the occupational, environmental, and medical settings. Methods: We searched the MEDLINE database using the Ovid V R search engine for the following terms cross-referenced to the MeSH database: ("occupational exposures" OR "environmental exposures") AND ("physiologic monitoring" OR "population surveillance"). The titles and abstracts of the resulted articles were reviewed for relevance. We expanded our search to include non-peer-reviewed publications and gray literature and resources using the same terms as utilized in the MEDLINE search. There were a total of 48 relevant peer-reviewed and non-peer-reviewed publications. Publications excluded contained no information relevant to medical monitoring following potentially harmful toxicologic exposures, discussed only worker screening/surveillance and/or population biomonitoring, contained redundant information, or were superseded by more recent information.

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“…(Nolan et al, 2012) Development of lung dysfunction following particulate exposure is a major health concern worldwide. The prevalence of metabolic syndrome is high in industrialized nations and is rapidly increasing in developing nations where high ambient particulates are also a tremendous health concern.…”

Section: Introductionmentioning

confidence: 99%