Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor

Park, Kyo Hoon; Lee, Kyong-No; Oh, Eunji; Im, Eun Mi

doi:10.1016/j.cyto.2023.156308

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…Moreover, there are ongoing studies on several other biomarkers which might help predict PTB [ 38 , 51 , 52 ]. First of all, inflammatory markers are analyzed, such as the proinflammatory interleukins of cytokines found in the maternal serum [ 51 ] or in cervical secretions [ 53 ]. The study by Laudanski et al showed that the levels of IGFBP-1, Eotaxin-1, BLC, BDNF, and MIP-1d measured in the serum might serve as predictive indicators for preterm labour.…”

Section: Discussionmentioning

confidence: 99%

Placental Cannabinoid Receptor Expression in Preterm Birth

Feduniw,

Krupa,

Łagowska

et al. 2024

Journal of Pregnancy

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Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the CBR in the placenta and the incidence of PTB.Methods: This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, that is, Group 3, consisted of 14 women who delivered at term, and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, and CBR2).Results: The study used reverse transcription and real-time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1, and CBR1a receptors was significantly lower in the placentas of women after PTB compared to those after term births, p=0.038, 0.033, and 0.034, respectively.Conclusions: The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of CBRs could serve as an indicator in predicting PTB.

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Section: Discussionmentioning

confidence: 99%

Placental Cannabinoid Receptor Expression in Preterm Birth

Feduniw,

Krupa,

Łagowska

et al. 2024

Journal of Pregnancy

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Absolute counts of leukocyte subsets in peripheral blood in pregnancies complicated by preterm prelabour rupture of membranes

Soucek,

Kacerovsky,

Kacerovska Musilova

et al. 2024

Journal of Obstetrics and Gynaecology

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Local inflammatory factors in pregnant women with various methods of cervical insufficiency treatment

Chernega,

Bila,

Zahorodnia

2024

USMYJ

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the reasons for the formation of cervical insufficiency are considred to be different from violation of the ratio of connective tissue elements due to its genetic characteristics to hormonal imbalance, and the predominance of pro-inflammatory factors of the immune system. A special attention is devoted to clinical situations, when cervical insufficiency was diagnosed in terms 22-24 weeks, the treatment means an alternative between emergency cerclage and obstetric pessary. The gaol of study – to compare dynamic of vaginal microbiota and local cervical immune factors by use of different cervical insufficiency treatment methods. Materials and methods. 81 pregnant with cervical insufficiency, diagnosed in term 22-24 weeks were observed, 47 pregnant treated by cerclage procedure (group A), and 34 were fitted with an obstetric pessary (group B). 30 healthy pregnant women in the period of 22 weeks formed group C. In all patients before treatment and every two weeks after it microscopy of vaginal discharges according to Hay/Ison criteria and evaluation of cervical cytokines were performed. Results. The balance by obstetric pessary use of type I and type III by Hay-Ison criteria being similar before treatment with pregnancy prolongation is changing dramatically to the prevalence of bacterial vaginosis be use of obstetric pessary – from 30,3% and 21,2% in 2 weeks to 25,0% and 41,7% in 6 weeks, by cerclage – from 43,5% and 14,9% in 2 weeks to 30,3% and 17,5% in 6 weeks. Patients with cervical insufficiency have increased concentration of IL-6 and IL-10, but by use of obstetrical pessary additionally growth of IL-8 from 42,3 pg/ml in 2 weeks to 187,6 pg/ml in 6 weeks is registered as well as decreasing of SLPI from 1,5 μg/ml to 0,6 μg/ml. Both changes show progression of inflammation and are associated with worth pregnancy outcomes. In the same time, cerclage is assocated with growth of SLPI from 1,9 μg/ml to 4,3 μμg/ml, what is a marker of adequate immune reaction by pregnancy. There is a difference between the groups of cerclage and obstetric pessary in dynamic of microbiota changes - a tendency to increasing of laboratory criteria of bacterial vaginosis frequency in group of obstetric pessary in 2 weeks becomes significant in 4 and more in 6 weeks comparing with group of cerclage. Proper to cervical insufficiency high concentration of proinflammatory IL-6 and IL-10 by use of obstetrical pessary is complicated by increasing of IL-8 and decreasing of SLPI, what means an activation of cervical inflammation, by cerclage – a increasing of SLPI is observed, what is favourable for pregnancy.

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Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor

Cited by 3 publications

References 60 publications

Placental Cannabinoid Receptor Expression in Preterm Birth

Placental Cannabinoid Receptor Expression in Preterm Birth

Absolute counts of leukocyte subsets in peripheral blood in pregnancies complicated by preterm prelabour rupture of membranes

Local inflammatory factors in pregnant women with various methods of cervical insufficiency treatment

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