Inflammatory biomarkers as prognostic indicators of liver cirrhosis

Tawfik, Naglaa; Elgendy, Naglaa A.; elhassan, Hanaa A. Abou; Ebrihem, Eman Elshohat; Saleh, Rayyh A. M.

doi:10.1016/j.jare.2019.02.018

Cited by 3 publications

(4 citation statements)

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“…This finding could be attributed to several factors. First, bacterial translocation and the associating endotoxaemia which are implicated in the development of SBP and systemic inflammation in cirrhosis directly increase the production of vasopressin and copeptin independently of osmotic stimuli or baroreceptor activity, as evidenced by the significant correlation of copeptin with markers of systemic inflammation, namely CRP and WBCs, as been demonstrated in previous studies [ 7 , 9 , 14 , 15 ]. Moreover, copeptin was significantly elevated in patients presenting with SIRS criteria ( p = 0.036).…”

Section: Discussionmentioning

confidence: 73%

“…Recent studies have shown that copeptin, independent of liver-specific scoring systems, predicts disease progression and prognosis in cirrhotic patients [ 7 ]. To the best of our knowledge, few studies have addressed the relationship between copeptin and sepsis in cirrhosis; moreover, they were performed on variable types of infections [ 3 , 9 ]. Therefore, we conducted this study with a focus on its possible role in patients with SBP.…”

Section: Introductionmentioning

confidence: 99%

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Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis

Abudeif¹,

Hashim²,

Ahmed³

et al. 2023

ceh

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Aim of the study: We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP). Material and methods: This cross-sectional study included 89 cirrhotic ascitic patients (37 with SBP and 52 without SBP) admitted to Sohag University Hospitals, Egypt, between June 2021 and February 2022. Serum copeptin was measured in all patients, and its association with SBP and other complications of liver cirrhosis was investigated. Results: Serum copeptin was significantly elevated in patients with SBP compared to those without SBP (p = 0.032) and significantly correlated with ascitic fluid study parameters, systemic inflammatory markers, and liver, renal, and circulatory functions. Serum copeptin and C-reactive protein (CRP) were independent risk factors for the presence of SBP. Serum copeptin detects SBP at a cut-off value of 9 pmol/l, with sensitivity and specificity of 73% and 64%, respectively. Serum copeptin was significantly associated with hepatic encephalopathy, gastrointestinal bleeding, hepatorenal syndrome, and larger amounts of ascites. Conclusions: Serum copeptin is an independent risk factor for the presence of SBP and significantly increased in patients presented with major complications of liver cirrhosis, demonstrating its ability to reflect circulatory dysfunction and systemic inflammation.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis

Abudeif¹,

Hashim²,

Ahmed³

et al. 2023

ceh

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“…The above findings were statistically significant when compared with healthy individuals with a p-value < 0.001, except for serum creatinine and serum potassium, which showed a p-value > 0.05. Similarly, Tawfik et al [ 12 ] and Sreenivas et al [ 6 ] found comparable results.…”

Section: Discussionmentioning

confidence: 61%

Trends of Chronic Liver Disease in a Tertiary Care Centre in the Eastern Part of India: A Retrospective Study

Mehta¹,

Sunny²,

Nafe³

et al. 2023

Cureus

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Aim of the study: To assess the relationship between the severity of liver cirrhosis and its outcomes based on laboratory parameters, Child-Turcotte-Pugh (CTP) score, and upper gastrointestinal (UGI) endoscopy findings.Background: Cirrhosis is the end stage of chronic liver disease (CLD) and is characterised by progressive liver fibrosis and distortion of the liver architecture. It is a major cause of morbidity and mortality all over the world. Cirrhosis is compensated in the initial stages and later progresses to the decompensated stage with various complications. The CTP scoring system predicts mortality in patients with cirrhosis.

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“…Copeptin may be used to diagnose liver cirrhosis and explain systemic infections that contribute to the progression of the condition [29]. Moreover, Kerbert et al [18] reported that higher copeptin concentrations upon hospital admission are associated with acute-on-chronic liver failure (ACLF) in individuals hospitalized with acute decompensation (AD) and those with classic AD of cirrhosis.…”

Section: Copeptin As a Marker In Nonalcoholic Steatohepatitismentioning

confidence: 99%

Copeptin: A Novel Marker for Diagnosis and Prognosis of Various Diseases AssociatedWith Diabetes

Gomaa¹

2022

BIJGIM

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Copeptin is an arginine vasopressin (AVP) precursor whose C-terminal has evolved into 39 amino acids. This AVP precursor is converted into equimolar amounts of Copeptin, neurophysin II, and AVP. a strong connection between the release of AVP and copeptin was observed. Measurement of AVP concentration remains complicated since AVP is an unstable peptide and additionally it is bound by platelets. Copeptin remains stable in serum or plasma for several days in a warm environment. and testing for copeptin yields findings in one h. Consequently, the quantity of copeptin might serve as a perfect replacement for reflecting the level of AVP. Copeptin has become identified as a beneficial measure in various diseases. The physiology and structure of copeptin, as well as its potential, to act as a predictive and diagnostic indicator of different diseases associated with diabetes is the goal of the current review.

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Inflammatory biomarkers as prognostic indicators of liver cirrhosis

Cited by 3 publications

References 0 publications

Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis

Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis

Trends of Chronic Liver Disease in a Tertiary Care Centre in the Eastern Part of India: A Retrospective Study

Copeptin: A Novel Marker for Diagnosis and Prognosis of Various Diseases AssociatedWith Diabetes

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