Inflammatory biomarkers and lipid metabolism parameters in women with mild cognitive impairment and dementia

Zorkina, Yana; Abramova, Olga; Ushakova, Valeria; Andreyuk, D. S.; Andriushchenko, Nika; Павлов, К. А.; Savilov, Victor; Solovevа, Kristina; Kurmishev, Marat; Syunyakov, Timur; Karpenko, Olga; Andryushchenko, Alisa; Gurina, O. I.; Kostyuk, Georgiy; Morozova, Аnna

doi:10.1080/03630242.2023.2185750

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Inflammatory markers have also been implicated as predictors of dementia disorders. In a study entitled "Inflammatory biomarkers and lipid metabolism parameters in women with mild cognitive impairment and dementia", high density lipoprotein was low (N= 75 with dementia) [26]. Surprisingly, the inflammatory biomarkers IL-8 and TNF-alpha were extremely low in mild cognitive impairment but elevated in dementia.…”

Section: Negative Physical Predictorsmentioning

confidence: 99%

Dementia Disorders: A Narrative Review

Field

2024

J Clin Psychol Neurol

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This narrative review of research includes summaries of 40 papers on dementia disorders that were published during 2023. The publications of this period are primarily randomized controlled trials and systematic reviews/ meta-analyses of randomized controlled trials. A few of these are focused on the prevalence of dementia which approximated one per cent of the world’s population. Only a few studies focused on effects of dementia disorders including memory loss, discrimination, pain, depression and suicidality. Most of the studies addressed predictors of dementia disorders including neurotic personality, frequent tv/computer use and excessive exposure to metals. Loss of short-term memory and other negative experiences including negative life events, loneliness, stress and depression were also significant predictor variables in this recent literature. Physical conditions that were predictive of dementia included pain, hypertension, atrial fibrillation, multi-morbidities, inflammation, encephalitis and neuropathology. Potential underlying mechanisms included dysfunctional neurotransmitter systems (serotonergic, noradrenergic and dopaminergic) and gray matter loss in prefrontal, temporal and other regions associated with memory. Several research groups reported on effective interventions including a Mediterranean diet, plant-based diets, medicinal plants, psychedelics, second generation antidepressants, blood pressure medication, music therapy, aromatherapy and other alternative therapies. Methodological problems relate to the variability in the assessments of dementia disorders, the self-report measures and the cross-sectional data that are not definitive about directionality of predictors and effects of dementia disorders.

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Section: Negative Physical Predictorsmentioning

confidence: 99%

Dementia Disorders: A Narrative Review

Field

2024

J Clin Psychol Neurol

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“…Equally important are long-term studies on the same patient's cohorts, which allow for understanding the temporal course of the disease and identifying the main aspects of pathophysiological processes [55]. Previously, we conducted a comparative study of biomarkers of lipid metabolism and the immune system in patients with MCI and dementia, which showed changes in the levels of apolipoprotein A1 (Apo A1), HDL and some markers of the inflammatory process [56]. In the present work, we analyzed the trend of biomarker changes in patients with MCI one year after cognitive training to identify inflammatory blood markers that could potentially be associated with cognitive state.…”

Section: Introductionmentioning

confidence: 99%

Alteration of Blood Immune Biomarkers in MCI Patients with Different APOE Genotypes after Cognitive Training: A 1 Year Follow-Up Cohort Study

Abramova,

Zorkina,

Ushakova

et al. 2023

IJMS

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Many studies aim to detect the early phase of dementia. One of the major ways to achieve this is to identify corresponding biomarkers, particularly immune blood biomarkers. The objective of this study was to identify such biomarkers in patients with mild cognitive impairment (MCI) in an experiment that included cognitive training. A group of patients with MCI diagnoses over the age of 65 participated in the study (n = 136). Measurements of cognitive functions (using the Mini-Mental State Examination scale and Montreal Cognitive Assessment) and determination of 27 serum biomarkers were performed twice: on the first visit and on the second visit, one year after the cognitive training. APOE genotypes were also determined. Concentrations of EGF (F = 17; p = 0.00007), Eotaxin (F = 7.17; p = 0.008), GRO (F = 13.42; p = 0.0004), IL-8 (F = 8.16; p = 0.005), MCP-1 (F = 13.46; p = 0.0001) and MDC (F = 5.93; p = 0.016) increased after the cognitive training in MCI patients. All these parameters except IL-8 demonstrated a weak correlation with other immune parameters and were poorly represented in the principal component analysis. Differences in concentrations of IP-10, FGF-2, TGFa and VEGF in patients with MCI were associated with APOE genotype. Therefore, the study identified several immune blood biomarkers that could potentially be associated with changes in cognitive function.

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