Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors

Abstract

Cancer survivors show increased risk for non-communicable diseases and chronic lowgrade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an intervention with a home-based exercise program. Survivors of childhood ALL aged 16-30 years (n = 21) with a median age at diagnosis 4.9 (1.6-12.9) years and a median time of 15.9 years from diagnosis, and sex-and age-matched healthy controls (n = 21) were studied. Stored plasma samples were analyzed with Olink's 92-protein-wide Inflammation panel in 21 ALL long-term survivors at baseline, after a previous 16-week home-based exercise intervention (n = 17) and in 21 age-and sex-matched controls at baseline. Protein expression levels were compared between the groups. Inflammatory protein levels did not differ between the survivors and controls at baseline. Significantly reduced levels after the intervention were found in 11 proteins related to either vascular inflammation, insulin resistance, or both: tumor necrosis factor superfamily member 14 (TNFSF14), oncostatin M (OSM), monocyte chemoattractant protein 1 (MCP-1), MCP-2, fibroblast growth factor 21 (FGF-21), chemokine (C-C motif) ligand 4 (CCL4), transforming growth factor alpha (TGF-α), tumor necrosis factor-related apoptosisinducing ligand 10 (TRAIL), adenosine deaminase (ADA), chemokine (C-X-C motif) ligand 6 (CXCL6), and latency-associated peptide transforming growth factor beta 1

Proteomic insights into paediatric cancer: Unravelling molecular signatures and therapeutic opportunities

“…84 It can be used for early cancer detection, monitoring disease progression and evolution during treatment, evaluating resistance markers or understanding disease mechanisms. 53,[84][85][86][87][88][89][90] Proteins can be measured through liquid biopsy by capturing exosomes or circulating tumour cells. 84 Early detection of hepatoblastomas associated with cancer predisposition is performed in the clinic by regular measurements of serum alpha-fetoprotein.…”

“…It is especially valuable where invasive biopsies of primary or metastatic tumour would be risky or difficult and to avoid exposure to imaging radiation 84 . It can be used for early cancer detection, monitoring disease progression and evolution during treatment, evaluating resistance markers or understanding disease mechanisms 53,84–90 …”