“…24,32 In this regard, we have demonstrated in an experimental model of arthritis induced by T. gondii the presence of autoantibodies against retinal S antigen, iris antigens, type-II collagen, and proteoglycans, which positively correlated with clinical manifestations of arthritis and iridocyclitis. 33 In addition, autoantibodies against other members of the galectin family (Gal-3 and Gal-9) have been detected in physiological and pathologic settings, including colon carcinoma, Crohn's disease and systemic lupus erythematosus. 34 -37 In conclusion, our results highlight the clinical importance of specific anti-retinal Gal-1 antibodies in sera from patients with AU or IU, indicating their potential prognostic use in follow-up observation of inflammatory ocular diseases.…”