Inflammatory Arthritic Process, Iridocyclitis and Immune Response to Articular and Ocular Antigens in Wistar Rats Injected with T. gondii Trophozoites

Circulating Anti-galectin-1 Antibodies Are Associated with the Severity of Ocular Disease in Autoimmune and Infectious Uveitis

“…24,32 In this regard, we have demonstrated in an experimental model of arthritis induced by T. gondii the presence of autoantibodies against retinal S antigen, iris antigens, type-II collagen, and proteoglycans, which positively correlated with clinical manifestations of arthritis and iridocyclitis. 33 In addition, autoantibodies against other members of the galectin family (Gal-3 and Gal-9) have been detected in physiological and pathologic settings, including colon carcinoma, Crohn's disease and systemic lupus erythematosus. 34 -37 In conclusion, our results highlight the clinical importance of specific anti-retinal Gal-1 antibodies in sera from patients with AU or IU, indicating their potential prognostic use in follow-up observation of inflammatory ocular diseases.…”