Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells

Taş, İsa; Zhou, Rui; Park, So‐Yeon; Yang, Yi; Gamage, Chathurika D. B.; Son, Young–Jin; Paik, Man‐Jeong; Kim, Hangun

doi:10.1016/j.tiv.2019.05.022

Cited by 19 publications

(13 citation statements)

References 39 publications

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“…Release of IL-6 leads to hyperactivation of JAK/STAT3 by phosphorylation [23]. Growing evidence has shown that ambient PM exposure can trigger lung epithelial remodeling by invading the smallest airways [24][25][26]. Based on the result from the network pharmacological analysis using menthol and menthone of peppermint oil, the roles of IL-6 pro-inflammatory cytokines and JAK/STAT3 activation were explored in the present study.…”

Section: Discussionmentioning

confidence: 99%

Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis

Kim

Park

2020

Pharmaceuticals

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Fine particulate matter (PM) exposure exhibits a crucial risk factor to exacerbate airway epithelial remodeling, fibrosis, and pulmonary destruction in asthma. Based on the use of essential oils from aromatic plants on pain relief and anti-inflammatory properties, we investigated the inhibitory effects of essential oil derived from the Mentha species (MEO) against asthma exposed to PM10. The MEO (0.1 v/v %) was aerosolized by a nebulizer to ovalbumin and PM10-induced asthmatic mice. Histological changes were confirmed in the lung tissues. To define the mode of action of the MEO on asthma, a protein–protein interaction network was constructed using menthol and menthone as the major components of the MEO. Cytokine expression and the JAK2/STAT3 signaling pathway were analyzed in lung epithelial A549 cells co-treated with MEO and PM10. Inhalation of MEO by nebulization inhibited respiratory epithelium hyperplasia, collagen deposition, and goblet cell activation in asthmatic mice. Through a network pharmacological analysis, cytokine–cytokine receptor interaction and JAK/STAT was expected to be underlying mechanisms of MEO on asthma. Treatment with MEO significantly reduced the IL-6 levels with a decrease in pro-inflammatory and T helper 2-specific cytokines. PM10-induced phosphorylation of JAK2 and STAT3 was significantly decreased by MEO. Collectively, MEO may have an inhibitory effect on asthma under the condition of PM10 exposure through the IL-6/JAK2/STAT3 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis

Kim

Park

2020

Pharmaceuticals

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“…Interestingly, UFPs exhibit low levels of apoptosis, suggesting that the particles may cause impairment of mitochondrial-nuclear crosstalk, causing mitochondrial membrane depolarization, altered mitochondrial respiratory chain enzyme activity, and a reduction in the mitochondrial DNA copy number, altering redox homeostasis and inducing cell survival [28]. Exposure to PM 10 and PM 2.5 activates the NF-κB promoter and increases the levels and phosphorylation of NF-κB and its DNA binding activity, causing an anti-apoptotic effect on A549, BEAS-2B, murine alveolar macrophage RAW 264.7, and human umbilical vein endothelial cells (HUVEC) [26,[29][30][31][32][33][34][35]. Experiments using organ-level lung microfluidic systems have reported the induction of the anti-apoptotic pathways in lung epithelial cells [20].…”

Section: Cell Death Resistancementioning

confidence: 99%

“…Experiments using organ-level lung microfluidic systems have reported the induction of the anti-apoptotic pathways in lung epithelial cells [20]. The anti-apoptotic effect induced by PM 10 and PM 2.5 has been deeply investigated, and several signaling pathways including those involving oxidative stress are described [26,[33][34][35][36][37].…”

Section: Cell Death Resistancementioning

confidence: 99%

“…Metalloprotease deregulation and other signaling pathways have led to enhanced ability of invasion and orthotopic lung carcinoma metastasis in mice [57]. Thus, PM 10 and PM 2.5 are a potent signal transducer, deregulator of non-coding RNAs, and activator of the transcription of key regulators of the epithelial-mesenchymal transition, which are strongly linked to tumor progression and metastasis [35].…”

Section: Activation Of Invasion and Metastasismentioning

confidence: 99%

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Deciphering the Code between Air Pollution and Disease: The Effect of Particulate Matter on Cancer Hallmarks

Santibáñez-Andrade

Chirino

González-Ramírez

et al. 2019

IJMS

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Air pollution has been recognized as a global health problem, causing around 7 million deaths worldwide and representing one of the highest environmental crises that we are now facing. Close to 30% of new lung cancer cases are associated with air pollution, and the impact is more evident in major cities. In this review, we summarize and discuss the evidence regarding the effect of particulate matter (PM) and its impact in carcinogenesis, considering the “hallmarks of cancer” described by Hanahan and Weinberg in 2000 and 2011 as a guide to describing the findings that support the impact of particulate matter during the cancer continuum.

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“…Cancer is one of the most common diseases affecting millions of people worldwide every year, representing the second leading cause of mortality after cardiovascular disease [ 1 ]. Uncontrolled cell growth due to genetic alterations [ 2 ], environmental factors [ 3 ] such as smoking [ 4 ], incorrect diet [ 5 ], obesity [ 6 ], infections [ 7 ], ionizing radiation [ 8 ], stress [ 9 ] and environmental pollutants [ 10 ] are the common denominators of each type of neoplasm. Especially, genetic alterations, which include chromosomal abnormalities and genetic mutations, represent one of the most noticeable causes [ 11 ] that contribute to tumorigenesis, affecting cell growth and metastases development [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

Ardizzone

Calabrese

Campolo

et al. 2021

IJMS

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Cancer is a multifactorial disease that affects millions of people every year and is one of the most common causes of death in the world. The high mortality rate is very often linked to late diagnosis; in fact, nowadays there are a lack of efficient and specific markers for the early diagnosis and prognosis of cancer. In recent years, the discovery of new diagnostic markers, including microRNAs (miRNAs), has been an important turning point for cancer research. miRNAs are small, endogenous, non-coding RNAs that regulate gene expression. Compelling evidence has showed that many miRNAs are aberrantly expressed in human carcinomas and can act with either tumor-promoting or tumor-suppressing functions. miR-19a is one of the most investigated miRNAs, whose dysregulated expression is involved in different types of tumors and has been potentially associated with the prognosis of cancer patients. The aim of this review is to investigate the role of miR-19a in cancer, highlighting its involvement in cell proliferation, cell growth, cell death, tissue invasion and migration, as well as in angiogenesis. On these bases, miR-19a could prove to be truly useful as a potential diagnostic, prognostic, and therapeutic marker.

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Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells

Cited by 19 publications

References 39 publications

Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis

Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis

Deciphering the Code between Air Pollution and Disease: The Effect of Particulate Matter on Cancer Hallmarks

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis

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