Inflammatory and stress biomarker response of Aeromonas hydrophila infected rohu, Labeo rohita fingerlings to dietary microbial levan

Gupta, Sanjay Kumar; Sarkar, Biplab; Priyam, Manisha; Kumar, Neeraj; Naskar, S.; Foysal, Javed; Saurabh, Shailesh; Sharma, T. R.

doi:10.1016/j.aquaculture.2020.735020

Cited by 10 publications

(9 citation statements)

References 58 publications

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“…Yet another recent study in L. rohita attempted to decipher the molecular mechanism of the effector response (both innate as well as adaptive) provoked against pathogenic attack. This study correlated the improved immune response presented in their previous study 113 with the upregulated immune‐responsive genes and downregulated regulatory genes in the latter one 114 . The findings were also accompanied by significant alterations in the levels of stress biomarkers 114 …”

Section: Immunostimulantssupporting

confidence: 76%

“…This study correlated the improved immune response presented in their previous study 113 with the upregulated immune-responsive genes and downregulated regulatory genes in the latter one. 114 The findings were also accompanied by significant alterations in the levels of stress biomarkers. 114…”

Section: Levanmentioning

confidence: 97%

“…110 Infact, the study also noted an increase in IL-10 111 which was in contrast to the findings obtained with levan. [112][113][114] Another similar study undertaken in the same year investigated the efficacy of biofloc-based system on immunological responses of L. rohita. 115 The study came out with the fact that in situ maintenance of water quality and the presence of microbial floc enhanced immunity and survival of the cultured fishes within the biofloc system.…”

Section: Probiotic Consortiamentioning

confidence: 99%

“…112 Further, a deeper insight into the mechanistic approach of immune protection by dietary supplementation of microbial levan in L. rohita was undertaken. 113,114 The study outcome depicted a time-dependent upregulation of pro-inflammatory cytokine genes and down-regulation of anti-inflammatory cytokines, in response to pathogen, A. hydrophila aggravated infection. 113 Yet another recent study in L. rohita attempted to decipher the molecular mechanism of the effector response (both innate as well as adaptive)…”

Section: Levanmentioning

confidence: 99%

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Immunomodulation by dietary supplements: A preventive health strategy for sustainable aquaculture of tropical freshwater fish, Labeo rohita (Hamilton, 1822)

Gupta

Priyam

et al. 2021

Reviews in Aquaculture

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Dietary supplementation is an effective strategy for boosting the innate immune response in fishes. It involves the use of functional ingredients that bear the potential for mitigating the deleterious effects of chemotherapeutics (bioaccumulation and development of drug-resistant pathogens), as a more ecologically responsible approach to fish farming. With the emergence of probiotics, prebiotics, synbiotics and herbal immunostimulants; dietary supplementation has become an integral aspect of immunonutrition. In this review, we have compiled a list of dietary immunostimulants in rohu, based on the research carried over the last ten years. It should be noted that nearly 25% of the studies on dietary supplementation in Labeo rohita investigated probiotics species (either singly or as mixtures), followed by the use of herbal supplements or phytobiotics. In relation to stress, about 30% of the studies dealt with the supplementation of tryptophan, followed by the incorporation of lipotropes. Moreover, approximately 55-60% of the studies reviewed, were restricted to nutrition-based disease resistance against Aeromonas hydrophila infection. Commercially available probiotics and herbal feed additives have been helpful in the health management of L. rohita to some extent. Ongoing research is consistently exploring novel ingredients inducing favourable immunomodulation to survive stress and widespread A. hydrophila infection in L. rohita. However, further investigations aiming at broad-spectrum disease resistance and multiple stress resilience are recommended. Efforts must also be directed towards the elucidation of specifically targeted response in vivo. Overall, greater insights into the molecular mechanisms of dietary supplementation of immunostimulants warrants the use of downstream analytical techniques and highthroughput screening tools.

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Section: Immunostimulantssupporting

confidence: 76%

Section: Levanmentioning

confidence: 97%

Section: Probiotic Consortiamentioning

confidence: 99%

Section: Levanmentioning

confidence: 99%

See 2 more Smart Citations

Immunomodulation by dietary supplements: A preventive health strategy for sustainable aquaculture of tropical freshwater fish, Labeo rohita (Hamilton, 1822)

Gupta

Priyam

et al. 2021

Reviews in Aquaculture

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“…Dietary levan supplementation after pathogenic challenge also increased lysozyme activity and the respiratory burst (release of reactive oxygen species) in serum and blood. Gupta and colleagues (2020) then showed that A. xylinum levan fed to A. hydrophila -challenged L. rohita fingerlings, led to increased Ig levels [ 138 ]. This levan also upregulated TLR22 expression (a PRR exclusive to fish) and IFN-γ in several organs of the fish including the intestine while the expression of TGF-β was mostly reduced [ 138 ].…”

Section: The Immunomodulatory Properties Of Microbial and Plant β-26-associated Fructans In Vivomentioning

confidence: 99%

The Immunomodulatory Properties of β-2,6 Fructans: A Comprehensive Review

2021

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Polysaccharides such as β-2,1-linked fructans including inulin or fructose oligosaccharides are well-known prebiotics with recognised immunomodulatory properties. In recent years, other fructan types covering β-2,6-linked fructans, particularly microbial levans, have gained increasing interest in the field. β-2,6-linked fructans of different degrees of polymerisation can be synthesised by plants or microbes including those that reside in the gastrointestinal tract. Accumulating evidence suggests a role for these β-2,6 fructans in modulating immune function. Here, we provide an overview of the sources and structures of β-2,6 fructans from plants and microbes and describe their ability to modulate immune function in vitro and in vivo along with the suggested mechanisms underpinning their immunomodulatory properties. Further, we discuss the limitations and perspectives pertinent to current studies and the potential applications of β-2,6 fructans including in gut health.

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