Inflammatory and Satellite Cells in the Quadriceps of Patients With COPD and Response to Resistance Training

Menon, Manoj K.; Houchen, Linzy; Singh, Sally; Morgan, Michael; Bradding, Peter; Steiner, Michael

doi:10.1378/chest.11-2144

Cited by 47 publications

(58 citation statements)

References 32 publications

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“…Our observations may reflect corticosteroid use, or overspill of systemic inflammation into muscle; however, whether there is a link between systemic and muscle inflammation remains unclear. It is interesting to note, however, that although neutrophil infiltration has been observed in the vastus lateralis muscle of COPD patients,33,34 muscle cytokine levels are not consistently elevated 35–37. In this study we also demonstrated that CRP positively correlated with BMI.…”

Section: Discussionsupporting

confidence: 48%

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease

Barker¹,

McKenna²,

Mistry³

et al. 2014

COPD

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BackgroundNutritional depletion is an important manifestation of chronic obstructive pulmonary disease (COPD), which has been related to systemic inflammation. It remains unclear to what degree airway inflammation contributes to the presence or progression of nutritional depletion.ObjectivesTo determine whether airway inflammation and lung bacterial colonization are related to nutritional status or predict progressive weight loss and muscle atrophy in patients with COPD.MethodsBody composition using dual energy X-ray absorptiometry, indices of airway inflammation, and bacterial colonization were measured in 234 COPD patients. Systemic inflammation was assessed from serum C reactive protein (CRP) and circulating total and differential leukocyte counts. Nutritional depletion was defined as a body mass index (BMI) less than 21 kg/m2 and/or fat-free mass index (FFMI) less than 15 or 17 kg/m2 in women and men, respectively. FFMI was calculated as the fat-free mass (FFM) corrected for body surface area. Measurements were repeated in 94 patients after a median 16-month follow-up. Regression analysis was used to assess the relationships of weight change and FFM change with indices of bacterial colonization and airway and systemic inflammation.ResultsNutritional depletion occurred in 37% of patients. Lung function was worsened in patients with nutritional depletion compared to those without (forced expiratory volume in 1 second 1.17 L versus 1.41 L, mean difference 0.24, 95% confidence interval 0.10 to 0.38, P<0.01). There were no differences in airway inflammation and bacterial colonization in patients with and without nutritional depletion. At baseline, BMI correlated positively with serum CRP (rs=0.14, P=0.04). Change in weight and change in FFM over time could not be predicted from baseline patient characteristics.ConclusionNutritional depletion and progressive muscle atrophy are not related to airway inflammation or bacterial colonization. Overspill of pulmonary inflammation is not a key driver of muscle atrophy in COPD.

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Section: Discussionsupporting

confidence: 48%

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease

Barker¹,

McKenna²,

Mistry³

et al. 2014

COPD

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“…A recent study of Menon et al . provided direct evidence for the important role of circulating neutrophils in extrapulmonary manifestations of COPD, by demonstrating that there was significant neutrophil infiltration in quadriceps muscle biopsies from COPD patients, and the number of neutrophils increased significantly after resistance exercise.…”

Section: Discussionmentioning

confidence: 94%

Expression of RANKL by peripheral neutrophils and its association with bone mineral density in COPD

Lin

et al. 2016

Respirology

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Background and objective: Osteoporosis is a major comorbidity of COPD, but the mechanistic links between diseases of the lung and the bone remain elusive. Human neutrophils express the osteoclast activation factor RANKL (receptor activator of NF-kB ligand) and act directly on osteoclasts to promote bone loss. Given that neutrophils are key effector cells in the pathogenesis of COPD, these same cells, by expressing RANKL, may be involved in osteoporosis of COPD. Methods: We enrolled 59 male patients with COPD, 32 smokers with normal lung function and 25 healthy non-smokers of the same gender as controls. The expression of RANKL on peripheral neutrophils was detected by flow cytometry. The plasma concentrations of pro-inflammatory cytokines were measured by ELISA. We analysed the association of RANKL + neutrophils with bone mineral density (BMD), lung function and the levels of cytokines. Results: RANKL + neutrophils in the blood of COPD patients were increased as compared to smokers and healthy controls, and the percentage of RANKL + neutrophils was higher in patients with low BMD as compared to those with normal BMD. The percentage of RANKL

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“…A quadriceps muscle fiber-type shift from oxidative type I fibers to glycolytic type II fibers is a consistent finding in COPD and is related to disease severity 21. Based on studies of the muscular adaptations to exercise in COPD compared to healthy age-matched subjects, it seems that RT could increase cross-sectional area22 and muscle mass,4 whereas ET appears to increase muscle oxidative capacity 10,11,23. In the present study, the proportion of type I fibers at baseline was low compared to reference values established in a healthy elderly population,24 and although not as low as observed in severe COPD,21 the results were similar to results from studies of milder staged COPD 25,26.…”

Section: Discussionmentioning

confidence: 94%

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

Iepsen¹,

Munch²,

Rugbjerg³

et al. 2016

COPD

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IntroductionExercise is an important countermeasure to limb muscle dysfunction in COPD. The two major training modalities in COPD rehabilitation, endurance training (ET) and resistance training (RT), may both be efficient in improving muscle strength, exercise capacity, and health-related quality of life, but the effects on quadriceps muscle characteristics have not been thoroughly described.MethodsThirty COPD patients (forced expiratory volume in 1 second: 56% of predicted, standard deviation [SD] 14) were randomized to 8 weeks of ET or RT. Vastus lateralis muscle biopsies were obtained before and after the training intervention to assess muscle morphology and metabolic and angiogenic factors. Symptom burden, exercise capacity (6-minute walking and cycle ergometer tests), and vascular function were also assessed.ResultsBoth training modalities improved symptom burden and exercise capacity with no difference between the two groups. The mean (SD) proportion of glycolytic type IIa muscle fibers was reduced after ET (from 48% [SD 11] to 42% [SD 10], P<0.05), whereas there was no significant change in muscle fiber distribution with RT. There was no effect of either training modality on muscle capillarization, angiogenic factors, or vascular function. After ET the muscle protein content of phosphofructokinase was reduced (P<0.05) and the citrate synthase content tended increase (P=0.08) but no change was observed after RT.ConclusionAlthough both ET and RT improve symptoms and exercise capacity, ET induces a more oxidative quadriceps muscle phenotype, counteracting muscle dysfunction in COPD.

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Inflammatory and Satellite Cells in the Quadriceps of Patients With COPD and Response to Resistance Training

Cited by 47 publications

References 32 publications

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease

Expression of RANKL by peripheral neutrophils and its association with bone mineral density in COPD

Effect of endurance versus resistance training on quadriceps muscle dysfunction in COPD: a pilot study

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