“…There is also evidence to suggest that TCE promotes immune‐mediated inflammatory diseases, hypersensitivity and autoimmunity in humans (Cooper et al, ; Dai et al, ; EPA, ; Huang et al, ; Khader, Gaffen, & Kolls, ; Parks & De Roos, ; Zhao et al, ). We and others have shown the effect of continuous developmental exposure to TCE in mice encompassing gestation, lactation, and early life generated CD4 + T‐cell alterations and/or early signs of tissue inflammation in both normal and autoimmune‐susceptible mouse strains (Blossom, Melnyk, Li, Wessinger, & Cooney, ; Gilbert, Woodruff, & Blossom, ; Peden‐Adams et al, ; Peden‐Adams et al, ). We recently reported that continuous developmental exposure to TCE beginning at gestation generated autoimmune hepatitis (AIH)‐like tissue pathology at postnatal day (PND) 259 even when TCE was removed from the drinking water at PND154 (Gilbert, Bai, Barnette, & Blossom, ).…”