Inflammatory and neuropathic pain conditions do not primarily evoke anxiety‐like behaviours in C57<scp>BL</scp>/6 mice

Pitzer, Claudia; Porta, Carmen La; Treede, Rolf‐Detlef; Tappe‐Theodor, Anke

doi:10.1002/ejp.1303

Cited by 40 publications

(50 citation statements)

References 90 publications

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“…Similar to rats, a single study found no depression-like behavior in the forced swimming test from the 3rd to 97th day following the SNI surgery in mice. Interestingly, this same study did not even detect anxiety-like behaviors under the same time point and pain conditions [52].…”

Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 74%

“…In the open field, no anxiety-like behavior was observed on day 7 [28], from day 3 to week 7 [12] and from day 3 to week 14 [52] after the SNI. Urban et al [12] also found a lack of anxiety-like behavior in the elevated zero-maze and marble-burying while Pitzer et al [52] in the elevated plus-maze and hole board. It is certainly not easy to understand the reason for this inconsistency.…”

Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 85%

“…Anxiety-like behavior was also observed in the black box emergency test on day 12 [35], in the marble-burying test, which also measures compulsive behavior [51] at day 30 [36,37], in the light-dark box on day 30 [36] and in the hole board test in weeks 4-6 [49]. In the open field, no anxiety-like behavior was observed on day 7 [28], from day 3 to week 7 [12] and from day 3 to week 14 [52] after the SNI. Urban et al [12] also found a lack of anxiety-like behavior in the elevated zero-maze and marble-burying while Pitzer et al [52] in the elevated plus-maze and hole board.…”

Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 87%

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Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain

Guida¹,

Gregorio

Palazzo³

et al. 2020

IJMS

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Neuropathic pain is a pathological condition induced by a lesion or disease affecting the somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted pathogenesis as it implicates several molecular signaling pathways involving peripheral and central nervous systems. Affective and cognitive dysfunctions have been reported as comorbidities of neuropathic pain states, supporting the notion that pain and mood disorders share some common pathogenetic mechanisms. The understanding of these pathophysiological mechanisms requires the development of animal models mimicking, as far as possible, clinical neuropathic pain symptoms. Among them, the Spared Nerve Injury (SNI) model has been largely characterized in terms of behavioral and functional alterations. This model is associated with changes in neuronal firing activity at spinal and supraspinal levels, and induces late neuropsychiatric disorders (such as anxious-like and depressive-like behaviors, and cognitive impairments) comparable to an advanced phase of neuropathy. The goal of this review is to summarize current findings in preclinical research, employing the SNI model as a tool for identifying pathophysiological mechanisms of neuropathic pain and testing pharmacological agent.

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Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 74%

Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 85%

Section: Behavioral Symptoms Associated With the Spared Nerve Injurymentioning

confidence: 87%

See 1 more Smart Citation

Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain

Guida¹,

Gregorio

Palazzo³

et al. 2020

IJMS

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“…1A-E. Overall, repeated measures (RM) ANCOVA with second/last pre-surgical baseline as covariate, demonstrated overall significant effects of strain (F [4,74] = 5.697, P < 0.0001), surgery (F [1,74] = 166.3, P < 0.0001), and a strain*surgery interaction (F [4,74] = 8.639, P < 0.0001), indicating that the effect of surgery was not similar for all strains. We therefore performed two-way RM ANOVA for each individual strain, and found the effect of surgery to be significant for all strains, except for the Lewis strain (F F344/ICO [1,330] = 94.24, P < 0.0001.…”

Section: Development Of Mechanical Allodynia Following Nerve Injury mentioning

confidence: 88%

The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury

Hestehave

Abelson

Pedersen

et al. 2020

Sci Rep

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Back-translating the clinical manifestations of human disease burden into animal models is increasingly recognized as an important facet of preclinical drug discovery. We hypothesized that inbred rat strains possessing stress hyper-reactive-, depressive- or anxiety-like phenotypes may possess more translational value than common outbred strains for modeling neuropathic pain. Rats (inbred: LEW, WKY, F344/ICO and F344/DU, outbred: Crl:SD) were exposed to Spared Nerve Injury (SNI) and evaluated routinely for 6 months on behaviours related to pain (von Frey stimulation and CatWalk-gait analysis), anxiety (elevated plus maze, EPM) and depression (sucrose preference test, SPT). Markers of stress reactivity together with spinal/brain opioid receptor expression were also measured. All strains variously developed mechanical allodynia after SNI with the exception of stress-hyporesponsive LEW rats, despite all strains displaying similar functional gait-deficits after injury. However, affective changes reflective of anxiety- and depressive-like behaviour were only observed for F344/DU in the EPM, and for Crl:SD in SPT. Although differences in stress reactivity and opioid receptor expression occurred, overall they were relatively unaffected by SNI. Thus, anxio-depressive behaviours did not develop in all strains after nerve injury, and correlated only modestly with degree of pain sensitivity or with genetic predisposition to stress and/or affective disturbances.

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“…Human studies have shown a positive correlation between DED severity and symptoms of anxiety 7,[60][61][62] . While there have been some reports of increased signs of anxiety in chronic pain models, other reports have not found a significant effect of pain on anxiety measures [63][64][65][66][67][68][69][70] . Using the elevated plus maze, single LGE reduced open arm time only in female mice, whereas double LGE reduced open arm time in both female and male mice.…”

Section: Discussionmentioning

confidence: 92%

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors

Mecum

Demers

Sullivan

et al. 2020

Sci Rep

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Lacrimal gland excision (LGE) induced dry eye produces more severe corneal damage in female mice, yet signs of LGE-induced ocular pain and anxiety in male and female mice have not been characterized. Excision of either the extraorbital gland (single LGE), or both the extraorbital and intraorbital glands (double LGE) was performed in male and female C57BL/6J mice to induce moderate and severe dry eye. Ongoing pain was assessed by quantifying palpebral opening and evoked nociceptive responses after corneal application of capsaicin and menthol. The open-field and plus maze were used to assess anxiety. Single LGE caused a reduction in palpebral opening and an increase in capsaicin and menthol-evoked responses only in female mice. Furthermore, single LGE produced signs of increased anxiety in female but not male mice. Overall, female mice appear more susceptible to signs of ocular pain, irritation, and anxiety in response to aqueous tear deficiency.

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Inflammatory and neuropathic pain conditions do not primarily evoke anxiety‐like behaviours in C57BL/6 mice

Abstract: Anxiety-like behaviour is not primarily altered following CFA and SNI in C57BL6 mice, irrespective of the gender, mouse sub-strain, housing conditions or affected body side within the herein investigated time period.

Cited by 40 publications

References 90 publications

Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain

Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain

The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury

Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors

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