Inflammatory and metabolic changes of severe obese women after 6 months of a Roux‐en‐Y gastric bypass

Abstract

Obesity is a chronic disease related to adipokines production, which contribute to inflammation and metabolic abnormalities. The Roux‐en‐Y gastric bypass is an alternative therapy for the treatment of severe obesity, reaching weight loss superior to conventional therapies. The aim was observed the inflammatory and metabolic changes after 6 months of Roux‐en‐Y gastric bypass. Nine women aged 24 – 48 years old, BMI > 35 kg/m2 (50.9±9.6), submitted to Roux‐en‐Y gastric bypass. Plasma concentrations evaluated: glucose (mg/dL), leptin (pg/mL), adiponectin (ng/mL), TNF‐α (pg/mL) and IL‐6 (pg/mL). Anthropometric assessment: weight (kg), BMI (kg/m2) and fat mass (FM: kg). We observed reduction in body weight (130.1±23.8 × 98.5±25.2, p<0.01) and FM (72.1±17.4 × 40.8±8.3, p<0.01). Significant metabolic changes were found, such as reduction in leptin [431.3 (303.8 – 532.2) × 96.7 (62.0 – 176.8), p<0.01] and glucose [97.0 (84.5 – 107.5) × 82.0 (74.7 – 85.0), p=0.04] and increased adiponectin (62.7±21. 2 × 206.0±120.8, p<0.01). With respect to pro‐inflammatory parameters, no significant changes were observed in TNF‐α (0.44±0.69 × 0.3±0.5, p=0.20) and IL‐6 [4.7 (3.2 – 7.6) × 1.8 (0.9 – 3.8), p=0.12]. Six months after surgery decreased fat mass and resulting in changes as decreased leptin and glucose and increased adiponectin. In other hand in this period there was no change in inflammatory parameters.