Inflammatory and infectious risk factors are associated with the response to tocolysis in patients with preterm labor

Torricelli, Michela; Voltolini, Chiara; Conti, Nathalie; Bonis, Maria De; Biliotti, Giulia; Picciolini, Enrico

doi:10.3109/14767058.2010.482614

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Inflammation, even when it has a subclinical character, has been suggested to play an important role in inducing preterm uterine contractility and influences the duration of labor. Our findings could support the hypothesis that inflammation is the main risk factor for early preterm labor between 24 and 28 weeks of pregnancy (7,13). Some authors maintain that roughly 50% of spontaneous preterm births are associated with infection; intrauterine infection may lead to a maternal and fetal prostaglandin cascade and induce uterine contractility (13,23).…”

Section: Discussionsupporting

confidence: 86%

“…The COX‐2 mRNA expression was twice as high in the preterm PROM patients with clinical signs of intrauterine infection. Inflammation seems to be a significant risk factor in a certain group of patients delivering preterm (7).…”

Section: Discussionmentioning

confidence: 99%

“…Prevention of preterm delivery is considered to be the most important perinatal challenge in developed countries (1–3). Traditional research methodologies for studying preterm labor have focused on testing the functions of selected risk factors and the mechanism of preterm uterine contractility (4–7). The best approach for understanding the pathophysiology of preterm parturition is to analyse the molecular pathway of different groups of tocolytic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Expression of selected genes in preterm premature rupture of fetal membranes

Kuć¹,

Laudański²,

Kowalczuk

et al. 2012

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of selected genes in preterm premature rupture of fetal membranes

Kuć¹,

Laudański²,

Kowalczuk

et al. 2012

Acta Obstet Gynecol Scand

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“…On the other hand, inflammatory cytokines and mediators (such as CRP) due to periodontal inflammation also play a key role, perpetuating this inflammatory response 59 . Lastly, high levels of maternal CRP in early pregnancy are associated with preterm birth [60][61][62] , and PD might be seen as a contributing element for this unpleasant outcome.…”

Section: Discussionmentioning

confidence: 99%

Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey

Escalda

Botelho

Mendes

et al. 2021

Sci Rep

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To explore the association between bacterial vaginosis (BV) and periodontitis (PD) and to determine whether PD and BV might be linked with systemic serum alterations. We used the National Health and Nutrition Examination Survey 2001–2004, with women aged 18–49 years old and diagnosed with or without BV according to Nugent’s method. PD was defined according to the 2012 case definition. We compared serum counts according to the presence of PD and the presence of BV. Multivariable regression was used to explore and identify relevant variables towards the presence of BV. 961 women fulfilled the inclusion criteria. In women with BV, PD was associated with higher inflammation, characterized by increased white blood cells (p = 0.006) and lymphocyte (p = 0.009) counts. Predictive models presented a statistically significant association between PD and BV [Odds Ratio (OD) = 1.69, 95% Confidence Interval (CI): 1.09–2.61 for periodontitis; OD = 2.37, 95% CI: 1.30–4.29 for severe PD]. Fully adjusted models for age, smoking, body mass index, diabetes mellitus and number of systemic conditions reinforced this association [OD = 1.71, 95% CI: 1.06–2.76 for PD; OD = 2.21, 95% CI: 1.15–4.25 for severe PD]. An association between BV and PD is conceivable. PD was associated with higher systemic markers of inflammation in women with BV. Our data is novel and could serve as a foundation to guide future studies in the confirmation of this association and the underlying mechanisms.

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“…Intra-amniotic infection is a well-established cause of spontaneous preterm delivery, and occurs in approximately 25% of women with a singleton gestation who deliver a preterm neonate (12). Its presence is a risk factor for impending preterm delivery (despite tocolytic administration) and adverse neonatal outcome (4,(12)(13)(14)(15)(16)(17)(18)(19). Intra-amniotic inflammation is more common than intra-amniotic infection and carries similar risk for adverse pregnancy and neonatal outcomes (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

434: The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes

Yoon

Romero

et al. 2009

American Journal of Obstetrics and Gynecology

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Objective-To evaluate the frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes.Study Design-Amniotic fluid (AF) was retrieved from both sacs in 90 twin gestations with preterm labor and intact membranes (GA between 20+0 and 34+6 weeks). Preterm labor was defined as the presence of painful regular uterine contractions, with a frequency of at least 2 every 10 minutes, requiring hospitalization. Fluid was cultured and assayed for matrix metalloproteinase-8. Intra-amniotic inflammation was defined as an AF matrix metalloproteinase-8 concentration >23 ng/mL.Results-The prevalence of intra-amniotic inflammation of at least 1 amniotic sac was 39% (35/90), while that of proven intra-amniotic infection for at least 1 amniotic sac was 10% (9/90). Intra-amniotic inflammation without proven microbial invasion of the amniotic cavity was found in 29% (26/90) of cases. Intra-amniotic inflammation was present in both amniotic sacs in 22 cases, in the presenting amniotic sac in 12 cases, and in the non-presenting amniotic sac in 1 case. Women with intra-amniotic inflammation observed in at least 1 amniotic sac and a negative AF culture for microorganisms had a significantly higher rate of adverse pregnancy outcome than

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Inflammatory and infectious risk factors are associated with the response to tocolysis in patients with preterm labor

Abstract: This retrospective study suggested that in women affected by preterm labor, the long-term tocolysis with intravenous ritodrine is able to prolong gestation beyond 7 days, in absence of inflammatory/infective risk factors of PTD.

Cited by 5 publications

References 32 publications

Expression of selected genes in preterm premature rupture of fetal membranes

Expression of selected genes in preterm premature rupture of fetal membranes

Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey

434: The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes

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