Inflammatory and functional responses after (bio)diesel exhaust exposure in allergic sensitized mice. A comparison between diesel and biodiesel

Timmerman, Tirza; Brito, Jôse Mára de; Almeida, Natalia Madureira de; Almeida, Francine Maria de; Arantes-Costa, Fernanda Magalhães; Guimarães, Eliane Tigre; Lichtenfels, A.J.F.C.; Rivero, Dolores Helena Rodriguez Ferreira; Oliveira, Regiani Carvalho de; Lacerda, João Paulo Amorim de; Moraes, Jamille Moreira; Pimental, Danilo Augusto; Saraiva-Romanholo, Beatriz Mangueira; Saldiva, Paulo Hilário Nascimento; Vieira, Rodolfo de Paula; Mauad, Thaís

doi:10.1016/j.envpol.2019.06.085

Cited by 10 publications

(2 citation statements)

References 52 publications

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“…Previous epidemiological studies have reported that PM likely aggravates the respiratory symptoms and increases the morbidity and emergency department visits of asthma patients [ 11 , 12 ]. It has been confirmed that multiple prolonged exposures to PM can exacerbate airway inflammation in the house dust mite (HDM)-induced asthma model and the pathological mechanisms might be related to the transforming growth factor-beta (TGF-β), PD-L1, TH17 cells, and Treg cells [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Particulate matter exposure is highly correlated to pediatric asthma exacerbation

Yang

Zhang

Zhan

et al. 2021

Aging

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Asthma is a heterogeneous disease in which environmental factors play an important role, and the effect of particulate matter (PM) on the occurrence and severity of asthma is drawing more attention. This study aims to identify the correlation between PM and pediatric asthma exacerbation and explore the potential mechanisms. The asthma visits data (N = 16,779,739) in a university-based tertiary children’s hospital from January 2013 to December 2017 were collected, and the relationship between asthma visits and local PM concentration was analyzed. For further study, we established a house dust mite (HDM)-induced allergic airway inflammation model with PM intervention. We detected a correlation between PM concentration and pediatric asthma visits, especially in children under 6 years old. The in vivo data showed that PM aggravated HDM-induced airway inflammation, and IL-33 neutralizing antibody exerted a protective role. Our study suggests that PM is a risk factor in promoting pediatric asthma exacerbation, in which IL-33 might be a promising target.

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Section: Introductionmentioning

confidence: 99%

Particulate matter exposure is highly correlated to pediatric asthma exacerbation

Yang

Zhang

Zhan

et al. 2021

Aging

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“…Animals were exposed in a whole body chamber to diesel exhaust particles for one hour, five times a week, for 60 days by a stationary diesel electrical generator (BD-2500 CFE; Branco, China) fitted via a simple connection on its exhaust tube that was divided into three compartments: an exhibition room, machine room and room in which the particles were generated. The exhibition room consisted of a bench with exposure chambers, a pressure-regulating valve and an apparatus that measured PM2.5, NOx, NO 2 and NO levels [20,21].…”

Section: Exposure To Pollutantsmentioning

confidence: 99%

Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model

et al. 2020

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Chronic exposure to ambient levels of air pollution induces respiratory illness exacerbation by increasing inflammatory responses and apoptotic cells in pulmonary tissues. The ineffective phagocytosis of these apoptotic cells (efferocytosis) by macrophages has been considered an important factor in these pathological mechanisms. Depending on microenvironmental stimuli, macrophages can assume different phenotypes with different functional actions. M1 macrophages are recognized by their proinflammatory activity, whereas M2 macrophages play pivotal roles in responding to microorganisms and in efferocytosis to avoid the progression of inflammatory conditions. To verify how exposure to air pollutants interferes with macrophage polarization in emphysema development, we evaluated the different macrophage phenotypes in a PPE-induced model with the exposure to diesel exhaust particles. C57BL/6 mice received intranasal instillation of porcine pancreatic elastase (PPE) to induce emphysema, and the control groups received saline. Both groups were exposed to diesel exhaust particles or filtered air for 60 days according to the groups. We observed that both the diesel and PPE groups had an increase in alveolar enlargement, collagen and elastic fibers in the parenchyma and the number of macrophages, lymphocytes and epithelial cells in BAL, and these responses were exacerbated in animals that received PPE instillation prior to exposure to diesel exhaust particles. The same response pattern was found inCaspase-3 positive cell analysis, attesting to an increase in cell apoptosis, which is in agreement with the increase in M2 phenotype markers, measured by RT

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The health effects of traffic-related air pollution: A review focused the health effects of going green

Chen

Oliver

2022

Chemosphere

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Inflammatory and functional responses after (bio)diesel exhaust exposure in allergic sensitized mice. A comparison between diesel and biodiesel

Cited by 10 publications

References 52 publications

Particulate matter exposure is highly correlated to pediatric asthma exacerbation

Particulate matter exposure is highly correlated to pediatric asthma exacerbation

Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model

The health effects of traffic-related air pollution: A review focused the health effects of going green

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