Inflammatory and endothelial markers during the menstrual cycle

Chaireti, Roza; Lindahl, Tomas; Byström, Birgitta; Bremme, Katarina; Larsson, Anders

doi:10.3109/00365513.2015.1129670

Cited by 22 publications

(22 citation statements)

References 24 publications

(35 reference statements)

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“…Hence, it is possible that both the complexity of the inflammatory response to concussion as well as potentially divergent responses in males and females contribute to these mixed findings. In addition, it is conceivable that the menstrual cycle may have had an effect; immune function can vary widely with hormonal changes during the menstrual cycle, with potential immunosuppression in the luteal phase [35][36][37]. While it is still unclear why we observed that symptom burden was correlated with lower levels of inflammatory cytokines in females following SRC, the results of this investigation provide supportive evidence that inflammation following concussion should not be looked at without dichotomizing groups by sex.…”

Section: Discussionsupporting

confidence: 54%

The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion

et al. 2020

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Background: Inflammation appears to be an important component of concussion pathophysiology. However, its relationship to symptom burden is unclear. Therefore, the purpose of this study was to evaluate the relationship between symptoms and inflammatory biomarkers measured in the blood of male and female athletes following a sport-related concussion (SRC). Results: Forty athletes (n = 20 male, n = 20 female) from nine interuniversity sport teams at a single institution provided blood samples within one week of an SRC. Twenty inflammatory biomarkers were quantitated by immunoassay. The Sport Concussion Assessment Tool version 5 (SCAT-5) was used to evaluate symptoms. Partial least squares (PLS) analyses were used to evaluate the relationship(s) between biomarkers and symptoms. In males, a positive correlation between interferon (IFN)-γ and symptom severity was observed following SRC. The relationship between IFN-γ and symptoms was significant among all symptom clusters, with cognitive symptoms displaying the largest effect. In females, a significant negative relationship was observed between symptom severity and cytokines IFN-γ, tumor necrosis factor (TNF)-α, and myeloperoxidase (MPO); a positive relationship was observed between symptom severity and MCP-4. Inflammatory mediators were significantly associated with all symptom clusters in females; the somatic symptom cluster displayed the largest effect. Conclusion: These results provide supportive evidence of a divergent relationship between inflammation and symptom burden in male and female athletes following SRC. Future investigations should be cognizant of the potentially sexspecific pathophysiology underlying symptom presentation.

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Section: Discussionsupporting

confidence: 54%

The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion

et al. 2020

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“…FM being a chronic condition, it is important to ponder the potential side effects of long-term NSAID use 51. Most FM patients being women, the possible relationship between inflammation and levels of ovarian hormones in FM patients is also a possible area for future investigations 52–54…”

Section: Discussionmentioning

confidence: 99%

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

Bäckryd¹,

Tanum²,

Lind³

et al. 2017

JPR

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179

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In addition to central hyperexcitability and impaired top–down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the analysis of cytokines and other inflammation-related proteins in different body fluids, neuroinflammatory mechanisms are considered to be central to the pathophysiology of many chronic pain conditions. However, concerning FM, previous human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have looked only at a few predetermined cytokine candidates. Instead of analyzing only a few substances at a time, we used a new multiplex protein panel enabling simultaneous analysis of 92 inflammation-related proteins. Hence, we investigated the CSF and plasma inflammatory profiles of 40 FM patients compared with CSF from healthy controls (n=10) and plasma from blood donor controls (n=46). Using multivariate data analysis by projection, we found evidence of both neuroinflammation (as assessed in CSF) and chronic systemic inflammation (as assessed in plasma). Two groups of proteins (one for CSF and one for plasma) highly discriminating between patients and controls are presented. Notably, we found high levels of CSF chemokine CX3CL1 (also known as fractalkine). In addition, previous findings concerning IL-8 in FM were replicated, in both CSF and plasma. This is the first time that such an extensive inflammatory profile has been described for FM patients. Hence, FM seems to be characterized by objective biochemical alterations, and the lingering characterization of its mechanisms as essentially idiopathic or even psychogenic should be seen as definitively outdated.

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“…Indeed, the number and complexity of the variables [age, phase of the menstrual cycle (follicular/luteal phase), recent pregnancies and breast-feeding, menopause, hormone medications, etc.] which influence the fluctuation of inflammatory parameters probably require an ad hoc study (50). Nevertheless, by SEM analysis, our work provides new evidence of inflammation as a possible pathway linking irregular nocturnal working hours and morbidity.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers

Pavanello¹,

Stendardo²,

Mastrangelo³

et al. 2017

Front. Immunol.

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Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work. Within the framework of a cross-sectional study, such possible relationships were appraised by simultaneous equation model (SEM) technique among day and night-shift hospital workers. PTX3 levels, modulated by several aging conditions [i.e., body mass index (BMI) (beta = −0.22; p = 0.022), C-reactive protein (CRP) (beta = −0.07; p = 0.000), and cardiovascular diseases with hypertension included (CVD) (beta = −0.12; p = 0.000)], positively associate with LTL (coefficient = 0.15; p = 0.033). LTL, in turn is reduced by CVD (beta = −0.15; p = 0.000), binge drinking (beta = −0.10; p = 0.004), and CRP (beta = −0.05; p = 0.026). On the other hand, night-shift work, found to be remarkably free from aging risk factors [i.e., age (beta = −0.13; p = 0.017), BMI (beta = −0.17; p = 0.030), CVD (beta = −0.14; p = 0.000), and binge drinking (beta = −0.13; p = 0.000)], does associate almost significantly with reversed PTX3 (coefficient = −0.09; p = 0.089) and even with CRP (beta = 0.17; p = 0.000). In conclusion, the SEM analysis indicates that PTX3 is positively linked to LTL. The finding suggests a possible new role of this long pentraxin that, by orchestrating an efficient governance of inflammatory processes, may protect telomere from attrition, ensuring therefore the genetic stability of cells. The higher CRP levels among night-shift workers suggest that night-shift work is associated with increased systemic inflammation. This would make nocturnal workers more susceptible to premature aging.

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Inflammatory and endothelial markers during the menstrual cycle

Cited by 22 publications

References 24 publications

The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion

The relationship between symptom burden and systemic inflammation differs between male and female athletes following concussion

Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma

Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers

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