Inflammatory actinic keratosis following capecitabine therapy

Worsening Rash in a Patient With Metastatic Breast Cancer

“…In described cases, some patients were prescribed topical corticosteroids for symptomatic relief, but its use was not universal. Antoniolli and colleagues published a similar literature review and described a tendency for older studies to have included discontinuation of the drug, with a trend toward a treat through approach more recently. In all cases that reported outcomes, there was a partial or complete resolution of the inflammation of the AKs.…”

“…The interference of DNA and RNA synthesis via inhibition of thymidylate synthase that causes double-stranded DNA breaks is key to its cytotoxic mechanism of action . When administered systemically, capecitabine exhibits preferential accumulation in areas of active cell proliferation . This is associated with amplified responses in the skin and the resultant inflammation of AKs, while sparing normal skin.…”

“…1,9 When administered systemically, capecitabine exhibits preferential accumulation in areas of active cell proliferation. 8 This is associated with amplified responses in the skin and the resultant inflammation of AKs, while sparing normal skin.…”

Inflamación de las queratosis actínicas en pacientes bajo tratamiento con quimioterapia sistémica: revisión de las publicaciones médicas

“…La primera relación de quimioterapia y aparición de eritema o fotosensibilidad se notificó en 1962 como efecto del uso de 5-fluorouracilo 3 . En esta búsqueda se reconocieron 21 casos de inflamación de queratosis actínicas vinculados con la aplicación de quimioterapia sistémica, los cuales se muestran en la Tabla 1 [4][5][6][7][8][9][10][11][12][13][14][15][16][17] .…”

“…It is essential to recognize these events to offer appropriate treatment and improve the patients' quality of life. iniciar de forma concomitante tratamiento con capecitabina, sin especificar el tiempo de transcurrido entre el inicio de la medicación y el efecto adverso 17 . En la mayor parte de los casos, las áreas más afectadas fueron la cabeza y los miembros superiores.…”