Inflammation with the participation of arachidonic (AA) and linoleic acid (LA) derivatives (HETEs and HODEs) is necessary in the course of a normal reproductive cycle and pregnancy

Kikut, Justyna; Komorniak, Natalia; Ziętek, Maciej; Palma, Joanna

doi:10.1016/j.jri.2020.103177

Cited by 41 publications

(44 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several other research projects have associated an inadequate balance of n-3 and n-6 PUFA profiles during pregnancy with deleterious consequences for the child, such as neurodevelopment disorder [ 43 , 6 ], immune system disease [ 45 , 46 ] and cardiometabolic risk and adiposity [ 47 , 48 ]. In addition, AA is a precursor of prostaglandin and other metabolites, which play a key role in the late pregnancy period and delivery [ 49 ]. Nevertheless, an excessive activation of inflammatory mediators during pregnancy might lead to deleterious effects, such as gestational diabetes, preeclampsia or pre-term delivery [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Aparicio

Martín-Grau

Hernández‐Martínez

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background During pregnancy a high amount of fatty acids (FA) is necessary to meet foetus demands, which vary during gestation. The present study describes the changes in maternal fatty acid concentrations during pregnancy in a sample of pregnant women. Methods This is a longitudinal study of 479 pregnant women who were monitored from the first trimester to third trimester of pregnancy. Data on maternal characteristics were recorded and a serum sample was collected in each trimester. The fatty acid profile (saturated (SFA: total, lauric acid, myristic acid, palmitic acid, stearic acid), monounsaturated (MUFA: total, palmitoleic acid, oleic acid) and polyunsaturated fatty acids (PUFA: total omega-6 (n-6), linoleic acid, dihomo-γ-linolenic acid, arachidonic acid (AA), total omega-3 (n-3), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) was analysed with a gas chromatography-mass spectrometry combination. Results From the first trimester to third trimester of pregnancy, a significant increase in total SFA, total MUFA and total n-6 PUFA was found. (p < 0.001). Nevertheless, the serum concentration of arachidonic acid (AA), eicosapentaenoic acid (EPA) and total n-3 PUFA decreased during gestation (p < 0.001). A statistically non-significant result was observed for the docosahexaenoic acid (DHA) serum concentration between the first and third trimesters of pregnancy. Significant correlations were observed between each total fatty acid concentrations of the first and third trimesters. Conclusion The circulating serum concentration of SFA, MUFA and n-6 PUFA increases during pregnancy, whereas essential fatty acids such as AA and EPA decrease, and DHA remains unchanged. Further research is necessary to understand the role played by FA throughout gestation.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Aparicio

Martín-Grau

Hernández‐Martínez

et al. 2021

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…HETEs have essential functions: they function as PPAR ligands due to their binding capacity to nuclear receptor transcription factors. Additionally, they participate in protein kinase signaling activation, angiogenesis, and neuronal apoptosis [ 21 ]. Further, the ability of 12- and 15-HETE to activate the capsaicin-sensitive receptor correlates with pain signaling during inflammation [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, they participate in protein kinase signaling activation, angiogenesis, and neuronal apoptosis [ 21 ]. Further, the ability of 12- and 15-HETE to activate the capsaicin-sensitive receptor correlates with pain signaling during inflammation [ 21 ]. We found similar increases in AA metabolites in cord vs. maternal plasma at the time of delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Omega-6 FA metabolism generates pro-inflammatory eicosanoids such as lipoxins and leukotrienes. In contrast, n-3 FAs are precursors of anti-inflammatory eicosanoids and specialized pro-resolving mediators (SPMs) that exhibit protective functions [ 20 , 21 , 22 ]. Eicosanoids and their bioactive metabolites play central roles at all stages of inflammation, including initiation, progression, and resolution.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

Thompson

Ulu

Yuil‐Valdes

et al. 2022

IJMS

View full text Add to dashboard Cite

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They were then adjusted for maternal obesity (normal body mass index (BMI: ≤30 kg/m2) vs. obese BMI (>30 kg/m2) and smoking status (never vs. current/former smoker) using linear regression modeling. A p-value < 0.05 was considered statistically significant. Our study demonstrated a diverse panel of oxylipins from the lipoxygenase pathway present at the time of delivery. In addition, both omega-3 and omega-6 oxylipins demonstrated potential influences on the birth length and weight percentiles. The oxylipins present during pregnancy may influence fetal growth and development, suggesting potential metabolites to be used as biomarkers for infant outcomes.

show abstract

“…Oxidized fatty acids, such as HODE, are generated by the activation of oxygenases [ 55 , 56 ] (cyclooxygenases and lipoxygenases mainly, and cytochrome P450 to a minor extent) and by free radical mediated lipid peroxidation [ 57 ]. Enzymatic oxidation of fatty acids plays a pivotal role during a normal reproductive cycle and pregnancy [ 58 ]. However, elevated plasma HODE concentrations and their positive correlation with other oxidized lipids in ZIKV-induced microcephalic newborns appears more consistently linked to the systemic inflammatory profile and redox imbalanced environment of the ZIKV-infected placenta [ 22 – 24 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma lipidome profiling of newborns with antenatal exposure to Zika virus

et al. 2021

View full text Add to dashboard Cite

The 2015–2016 Zika virus (ZIKV) outbreak in Brazil was remarkably linked to the incidence of microcephaly and other deleterious clinical manifestations, including eye abnormalities, in newborns. It is known that ZIKV targets the placenta, triggering an inflammatory profile that may cause placental insufficiency. Transplacental lipid transport is delicately regulated during pregnancy and deficiency on the delivery of lipids such as arachidonic and docosahexaenoic acids may lead to deficits in both brain and retina during fetal development. Here, plasma lipidome profiles of ZIKV exposed microcephalic and normocephalic newborns were compared to non-infected controls. Our results reveal major alterations in circulating lipids from both ZIKV exposed newborns with and without microcephaly relative to controls. In newborns with microcephaly, the plasma concentrations of hydroxyoctadecadienoic acid (HODE), primarily as 13-HODE isomer, derived from linoleic acid were higher as compared to normocephalic ZIKV exposed newborns and controls. Total HODE concentrations were also positively associated with levels of other oxidized lipids and several circulating free fatty acids in newborns, indicating a possible plasma lipidome signature of microcephaly. Moreover, higher concentrations of lysophosphatidylcholine in ZIKV exposed normocephalic newborns relative to controls suggest a potential disruption of polyunsaturated fatty acids transport across the blood-brain barrier of fetuses. The latter data is particularly important given the neurocognitive and neurodevelopmental abnormalities observed in follow-up studies involving children with antenatal ZIKV exposure, but normocephalic at birth. Taken together, our data reveal that plasma lipidome alterations associated with antenatal exposure to ZIKV could contribute to identification and monitoring of the wide spectrum of clinical phenotypes at birth and further, during childhood.

show abstract

Inflammation with the participation of arachidonic (AA) and linoleic acid (LA) derivatives (HETEs and HODEs) is necessary in the course of a normal reproductive cycle and pregnancy

Cited by 41 publications

References 65 publications

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy

Omega-6 and Omega-3 Fatty Acid-Derived Oxylipins from the Lipoxygenase Pathway in Maternal and Umbilical Cord Plasma at Delivery and Their Relationship with Infant Growth

Plasma lipidome profiling of newborns with antenatal exposure to Zika virus

Contact Info

Product

Resources

About