Inflammation to skin malignancy, time to rethink the link: SCC in skin graft donor sites

Ponnuvelu, Geeta; Ng, M.F.Y.; Connolly, Cara; Hogg, Fiona J.; Naasan, Anas

doi:10.1016/j.surge.2010.08.006

Cited by 12 publications

(10 citation statements)

References 5 publications

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“…De novo SCC at skin graft site is relatively common in literature [14], but in our case, it is very unlikely that two different primary SCCs with the same degree of differentiation occurred within such a short interval of time. Survival of implanted tumor cells is rare, presumably because the normal body defense mechanisms operate.…”

Section: Discussionmentioning

confidence: 72%

Metastatic implantation of oral cancer in forearm: An unusual presentation

Biswas¹,

Dutta²,

Asit³

2020

IJCR

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Section: Discussionmentioning

confidence: 72%

Metastatic implantation of oral cancer in forearm: An unusual presentation

Biswas¹,

Dutta²,

Asit³

2020

IJCR

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“…In our review of the literature, we found a total of 16 documented cases. [5][6][7][8][9][10] Our case report represents a de novo occurrence of a well differentiated SCC at a skin graft donor site for reconstruction of chronically infected bilateral hip wounds. It can be inferred that our patient's chronic wounds were a factor for the development of SCC at the donor site.…”

Section: Discussionmentioning

confidence: 86%

“…Five of the previous case reports found SCC in skin graft donor sites in patients who were undergoing reconstruction with skin grafting for resected skin cancers, which indicates a potential relationship between the original cancer and the SCC arising at the donor site. [5][6][7][8][9] One case report demonstrated the implantation of SCC after using the same hollow bore needle for injection in both the area around the skin cancer and the donor site, indicating the cancer may have seeded into the donor site. 6 Other case reports describe patients who developed SCC at the skin graft donor sites who had undergone reconstruction after burns.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Thomas

Rezzadeh

Rossi

et al. 2021

Plastic Surgery Case Studies

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Introduction: Skin graft reconstruction is a common method of providing wound coverage. Rarely, skin grafting can be associated with the development of squamous cell carcinoma (SCC) in the graft donor site. Case Report: The patient is a 72-year old male with a 15-year history of bilateral hip wounds. He underwent a multitude of treatments previously with failed reconstructive efforts. After presenting to us, he underwent multiple debridements and eventual skin grafting. Within 4 weeks of the final skin graft, a mass developed at the skin graft donor site at the right thigh. Excisional biopsy returned a well differentiated keratinizing SCC. Discussion/Conclusion: This case demonstrates the acute presentation of SCC in a patient following a skin graft without known risk factors. The purpose of this unique case report is to highlight a very rare occurrence of SCC at a skin graft donor site.

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“…ESCC have been reported to arise at the sites of skin surgery, including the area affected by the primary tumor and split thickness skin graft (STSG) donor and recipient sites [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The best therapeutic option for ESCC after surgery in our opinion is still a challenge.…”

Section: Introductionmentioning

confidence: 99%

Eruptive non-melanoma skin cancers/squamous atypia following skin surgery. Report of two new cases, concise review of the literature with special emphasis on treatment options

Chessa

Picciola

Filippi

et al. 2022

Dermatol Pract Concept

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Multiple eruptive cutaneous non-melanoma skin cancers(NMSCs) have been reported to arise at the sites of skin surgery, including the area affected by the primary tumour and split thickness skin graft(STSG) donor and recipient sites. The aim of this study is to make a critical revision of the literature, analysing the clinical, histological features and outcomes of eruptive NMSCs after cutaneous surgery. Up to August 2021, according to our systematic review of the literature, we have collected 18 published articles and a total of 33 patients, including our two cases. The results of this review highlight five red flags that clinicians should consider: (i) lower and upper limbs represent the cutaneous site with the highest risk, representing 82.35% of the cases in the literature; (ii) the median time to onset of eruptive NMSCs that is approximately 6 weeks; (iii) primary NMSCs were completely excised with free margins on histologic examination in all cases of the literature, and therefore the eruptive NMSCs reported could not be considered recurrences; (iv) any surgical technique involves a risk to promote eruptive NMSCs; (v) treatment of eruptive NMSCs includes surgery or combined surgical and medical treatment. However, eruptive NMSCs recurrences are a real medical challenge and have always been treated combining surgical and medical treatment, with complete resolution in about one third of patients. In conclusion, even though the pathogenesis remains unclear, this review highlights 5 red flags which could support clinicians in the diagnosis and management of eruptive of NMSCs after skin surgery.

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Inflammation to skin malignancy, time to rethink the link: SCC in skin graft donor sites

Cited by 12 publications

References 5 publications

Metastatic implantation of oral cancer in forearm: An unusual presentation

Metastatic implantation of oral cancer in forearm: An unusual presentation

Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

Eruptive non-melanoma skin cancers/squamous atypia following skin surgery. Report of two new cases, concise review of the literature with special emphasis on treatment options

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