Inflammation to Infertility: Panoramic View on Endometriosis

Rasheed, Huda A Mohammed; Hamid, Pousette

doi:10.7759/cureus.11516

Cited by 20 publications

(17 citation statements)

References 48 publications

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“…However, the molecular mechanisms by which it affects infertility are complex. Several studies have shown a link between inflammation and infertility ( Weiss et al, 2009 ; Vaisi-Raygani and Asgari, 2021 ), especially inflammation of the peritoneal cavity ( Tao et al, 2018 ; Mohammed Rasheed and Hamid, 2020 ). Long-term chronic low-grade inflammation affects female fertility.…”

Section: Discussionmentioning

confidence: 99%

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2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

Lin

Yang

Chen

et al. 2022

Front. Cell Dev. Biol.

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Reduced fertility associated with normal aging may reflect the over-maturity of oocytes. It is increasingly important to reduce aging-induced infertility since recent trends show people marrying at later ages. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, has been reported to have anti-inflammatory and anti-aging properties. To evaluate whether THSG can reduce aging-related ovarian damage in a female mouse model of aging, THSG was administered by gavage at a dose of 10 mg/kg twice weekly, starting at 4 weeks of age in a group of young mice. In addition, the effect of THSG in a group of aged mice was also studied in mice starting at 24 weeks of age. The number of oocytes in the THSG-fed group was higher than in the untreated control group. Although the percentage of secondary polar bodies (PB2) decreased during aging in the THSG-fed group, it decreased much more slowly than in the age-matched control group. THSG administration increased the quality of ovaries in young mice becoming aged. Western blotting analyses also indicated that CYP19, PR-B, and ER-β expressions were significantly increased in 36-week-old mice. THSG also increased oocyte numbers in aged mice compared to mice without THSG fed. Studies of qPCR and immunohistochemistry (IHC) analyses of ovaries in the aged mice groups were conducted. THSG increased gene expression of anti-Müllerian hormone (AMH), a biomarker of oocyte number, and protein accumulation in 40-week-old mice. THSG increased the expression of pgc1α and atp6, mitochondrial biogenesis-related genes, and their protein expression. THSG also attenuated the fading rate of CYP11a and CYP19 associated with sex hormone synthesis. And THSG maintains a high level of ER-β expression, thereby enhancing the sensitivity of estrogen. Our findings indicated that THSG increased or extended gene expression involved in ovarian maintenance and rejuvenation in young and aged mice. On the other hand, THSG treatments significantly maintained oocyte quantity and quality in both groups of young and aged mice compared to each age-matched control group. In conclusion, THSG can delay aging-related menopause, and the antioxidant properties of THSG may make it suitable for preventing aging-induced infertility.

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Section: Discussionmentioning

confidence: 99%

“…Frontiers in Cell and Developmental Biology frontiersin.org especially inflammation of the peritoneal cavity (Tao et al, 2018;Mohammed Rasheed and Hamid, 2020). Long-term chronic lowgrade inflammation affects female fertility.…”

Section: Discussionmentioning

confidence: 99%

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

Lin

Yang

Chen

et al. 2022

Front. Cell Dev. Biol.

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“…Therefore, Aurora A may be related to endometriosis and endometrial hyperplasia. Endometriosis reduces implantation rate and decidualization [ 32 ]. Dienogest is often used for hysteroscopic surgical treatment of endometriosis [ 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway

Wang

Chen

Yang

2021

Reprod Biol Endocrinol

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Background Decidualization is essential to the successful pregnancy in mice. The molecular mechanisms and effects of Aurora kinase A (Aurora A) remain poorly understood during pregnancy. This study is the first to investigate the expression and role of Aurora A during mouse decidualization. Methods Quantitative real time polymerase chain reaction, western blotting and in situ hybridization were used to determine the expression of Aurora A in mouse uteri. Aurora A activity was inhibited by Aurora A inhibitor to explore the role of Aurora A on decidualization via regulating the Aurora A/Stat3/Plk1/Cdk1 signaling pathway. Results Aurora A was strongly expressed at implantation sites compared with inter-implantation sites. Furthermore, Aurora A was also significantly increased in oil-induced deciduoma compared with control. Both Aurora A mRNA and protein were significantly increased under in vitro decidualization. Under in vitro decidualization, Prl8a2, a marker of mouse decidualization, was significantly decreased by TC-S 7010, an Aurora A inhibitor. Additionally, Prl8a2 was reduced by Stat3 inhibitor, Plk1 inhibitor and Cdk1 inhibitor, respectively. Moreover, the protein levels of p-Stat3, p-Plk1 and p-Cdk1 were suppressed by TC-S 7010. The protein levels of p-Stat3, p-Plk1 and p-Cdk1 were also suppressed by S3I-201, a Stat3 inhibitor). SBE 13 HCl (Plk1 inhibitor) could reduce the protein levels of p-Plk1 and p-Cdk1. Collectively, Aurora A could regulate Stat3/Plk1/Cdk1 signaling pathway. Conclusion Our study shows that Aurora A is expressed in decidual cells and should be important for mouse decidualization. Aurora A/Stat3/Plk1/Cdk1 signaling pathway may be involved in mouse decidualization.

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“…Endometriosis is described as an estrogen-dependent state of chronic inflammation and has implications for fertility, affecting 35 to 45% of women with infertility [ 137 ]. Inflammation in endometriosis impairs decidualisation, which is the process whereby the endometrium changes in preparation for pregnancy, reduces progesterone (a sex steroid with anti-inflammatory properties), and causes disruption in the endometrium [ 138 ]. Recently, dietary interventions, particularly those with anti-inflammatory properties, have been shown to have a beneficial effect on endometriosis and fertility outcomes through these mechanisms [ 139 , 140 ].…”

Section: Anti-inflammatory Diets and Female Fertilitymentioning

confidence: 99%

Anti-Inflammatory Diets in Fertility: An Evidence Review

et al. 2022

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Infertility is a global health concern affecting 48 million couples and 186 million individuals worldwide. Infertility creates a significant economic and social burden for couples who wish to conceive and has been associated with suboptimal lifestyle factors, including poor diet and physical inactivity. Modifying preconception nutrition to better adhere with Food-Based Dietary Guidelines (FBDGs) is a non-invasive and potentially effective means for improving fertility outcomes. While several dietary patterns have been associated with fertility outcomes, the mechanistic links between diet and infertility remain unclear. A key mechanism outlined in the literature relates to the adverse effects of inflammation on fertility, potentially contributing to irregular menstrual cyclicity, implantation failure, and other negative reproductive sequelae. Therefore, dietary interventions which act to reduce inflammation may improve fertility outcomes. This review consistently shows that adherence to anti-inflammatory diets such as the Mediterranean diet (specifically, increased intake of monounsaturated and n-3 polyunsaturated fatty acids, flavonoids, and reduced intake of red and processed meat) improves fertility, assisted reproductive technology (ART) success, and sperm quality in men. Therefore, integration of anti-inflammatory dietary patterns as low-risk adjunctive fertility treatments may improve fertility partially or fully and reduce the need for prolonged or intensive pharmacological or surgical interventions.

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Inflammation to Infertility: Panoramic View on Endometriosis

Cited by 20 publications

References 48 publications

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging

Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway

Anti-Inflammatory Diets in Fertility: An Evidence Review

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