Inflammation-responsive nanocapsules for the dual-release of antibacterial drugs

Abstract

Herein, we design inflammation-responsive nanocapsules containing two antibiotics. The releases are programmed to be triggered in conditions occurring at the different stages of wound healing. The nanocapsules exhibits excellent antibacterial...

Advanced density-based methods for the characterization of materials, binding events, and kinetics

“…For example, MagLev is not suitable to study the kinetics of the hydrolysis and condensation of reactive alkoxysilanes to form silica nanoparticles because the sol-gel reaction would be completed before the sample reaches the equilibrium position. Indeed, silica nanocapsules with a diameter of 182 nm reached their levitation height after 6 h, 70 whereas tetraethyl orthosilicate was fully converted to silica nanocapsules after only 4 h. 115 (v) The paramagnetic medium does not affect the reaction/process.…”

“Smart” Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy

“…Despite tremendous research efforts, the problem of preventing such infections remained unmet medical needs. The intensive development of biomaterials provides many alternative approaches to prevent bacterial infections [12][13][14][15][16]: nanoparticles [14,15,17,18], micro-and nanocapsules [19,20], and hydrogels [21]. However, these materials have not yet found their application in the clinic for prolonged prophylaxis and therapy, largely due to the ineffective encapsulation of low molecular weight antibiotics and insufficient drug release time (only a few hours [22][23][24][25]).…”

Enhanced antibacterial activity of surface re-engineered lysozyme against Gram-negative bacteria without accumulated resistance

“…[8][9][10] A large amount of research has been done to find an effective therapeutic method against MDR Gramnegative pathogenic bacteria. [10][11][12][13][14] To synthesize feasible alternatives to antibiotics, one of the most effective ways is focusing on the re-engineering of natural sources of antimicrobial agents, such as phytochemicals, 11,15 antimicrobial peptides [16][17][18] and lysozyme. 19 The re-engineering process is generally achieved by constructing cationic antibacterial materials from these natural bactericides.…”

“…8–10 A large amount of research has been done to find an effective therapeutic method against MDR Gram-negative pathogenic bacteria. 10–14…”