“…However, uric acid levels are inversely associated with C-reactive protein (CRP) levels, and the association between the level of uric acid and severe COVID-19 progression differs significantly both with and without the inclusion of CRP levels. Low uric acid may contribute to severe COVID-19 progression via increased inflammation in subjects who do not exhibit signs of hyperuricemia [5]. This indicates that heritable hypouricemia, such as renal hypouricemia and xanthinuria, may be a risk factor for severe COVID-19; further studies are needed to elucidate this relationship.…”