Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

Yang, Kun; Hasegawa, Yuto; Bhattarai, Janardhan P.; Hua, Jun; Dower, Milan; Etyemez, Semra; Prasad, Neal; Duvall, Lauren; Paez, Adrian; Smith, Amy; Wang, Yingqi; Zhang, Yun-Feng; Lane, Andrew P.; Ishizuka, Koko; Kamath, Vidyulata; Ma, Minghong; Kamiya, Atsushi; Sawa, Akira

doi:10.1038/s41380-024-02425-8

Mol Psychiatry

2024

DOI: 10.1038/s41380-024-02425-8

|View full text |Cite

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

Kun Yang,

Yuto Hasegawa,

Janardhan P. Bhattarai

et al.

Help me understand this report

View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice

Parbst,

Kostka,

Günther

et al. 2024

Preprint

View full text Add to dashboard Cite

Neuronal activity in the olfactory bulb (OB) drives coordinated activity in the hippocampal-prefrontal network during early development. Inhibiting OB output in neonatal mice disrupts functional development of the hippocampal formation as well as cognitive abilities. These impairments manifest early in life and resemble dysfunctions of the hippocampus and the prefrontal cortex that have been linked to neuropsychiatric disorders. Thus, we investigated a disease mouse model and asked whether activity in the OB might be altered, thereby contributing to the dysfunctional development of the hippocampal-prefrontal network. We addressed this question by combining in vivo electrophysiology with behavioral assessment of immune-challenged Disc1+/- mice that mimic the dual genetic-environmental etiology of neuropsychiatric disorders. In wildtype mice, we found high DISC1 expression levels in OB projection neurons during development. Furthermore, neuronal and network activity in the OB, as well as the drive from the bulb to the hippocampal-prefrontal network were reduced in immune-challenged Disc1+/- mice during early development. This early deficit did not affect odor-evoked activity and odor perception but resulted in impaired long-term odor memory. We propose that reduced endogenous activity in the developing OB contributes to altered maturation of the hippocampal-prefrontal network, leading to memory impairment in immune-challenged Disc1+/- mice.

show abstract

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice

Parbst,

Kostka,

Günther

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

Cited by 1 publication

References 70 publications

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice

Contact Info

Product

Resources

About

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

Cited by 1 publication

References 70 publications

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1+/-mice

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1+/-mice

Contact Info

Product

Resources

About

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice

Developmental olfactory dysfunction and abnormal odor memory in immune-challengedDisc1^+/-mice