Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway

Li, Xunjia; Liu, Chengxuan; Li, Ying; Xiong, Weijian; Zuo, Deyu

doi:10.1080/21655979.2022.2038430

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Rats in the EPO group showed a significant increase in WBRV on day 5 and further increases from day 5 to day 11. Our data suggest that rhEPO causes an increase in blood viscosity significantly earlier than the end of administration in rats in other studies ( Wilcox et al, 1993 ; Li et al, 2022 ). This is due to the different purpose of the study.…”

Section: Discussionsupporting

confidence: 71%

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A local-saturation-and-delay MRI method for evaluation of red blood cells aggregation in vivo for tumor-bearing or drug-used rats

Shan

Shi²,

Liu³

et al. 2023

Front. Bioeng. Biotechnol.

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Hyperviscosity syndrome (HVS) is a combination of clinical signs and symptoms related to increased blood viscosity. HVS can increase the thrombotic risk by causing a major disturbance to the blood flow, which is usually found in the advanced stages of the tumor. Moreover, some of the drugs used in chemotherapy, such as 5-fluorouracil and erythropoietin, are also capable of causing HVS through their respective pathways. Clinically, the viscosity of a patient’s blood sample is measured by a rotary rheometer to estimate the risk of hyperviscosity syndrome. However, the measurement of blood viscosity in vitro is easily affected by storage time, storage environment, and anticoagulants. In addition, the fluid conditions in the rheometer are quite different from those in natural blood vessels, making this method inappropriate for evaluating blood viscosity and its effects in vivo under physiological condition. Herein, we presented a novel magnetic resonance imaging method called local-saturation-and-delay imaging (LSDI). The radial distributions of flow velocity measured by LSDI are consistent with the Ultrasonic (US) method (Spearman correlation coefficient r = 0.990). But the result of LSDI is more stable than US (p < 0.0001). With the LSDI method, we can directly measure the radial distribution of diastolic flow velocity, and further use these data to calculate the whole blood relative viscosity (WBRV) and erythrocyte aggregation trend. It was a strong correlation between the results measured by LSDI and rotary rheometer in the group of rats given erythropoietin. Furthermore, experimental results in glioma rats indicate that LSDI is equivalent to a rheometer as a method for predicting the risk of hyperviscosity syndrome. Therefore, LSDI, as a non-invasive method, can effectively follow the changes in WBRV in rats and avoid the effect of blood sampling during the experiment on the results. In conclusion, LSDI is expected to become a novel method for real-time in vivo recognition of the cancer progression and the influence of drugs on blood viscosity and RBC aggregation.

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Section: Discussionsupporting

confidence: 71%

“…For more details on the rats in EPO group, we refer to the previous work of Li et al (2022) . During administration, rats in the EPO and NC groups were scanned for WBRV using LSDI.…”

Section: Discussionmentioning

confidence: 99%

A local-saturation-and-delay MRI method for evaluation of red blood cells aggregation in vivo for tumor-bearing or drug-used rats

Shan

Shi²,

Liu³

et al. 2023

Front. Bioeng. Biotechnol.

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“…These data suggest that p38-mediated osteogenic differentiation of osteoblasts is mainly induced by IL-6. Previous studies have shown that inflammatory responses induce calcification by activating p38 and that IL-6, in collaboration with IL-11, is responsible for transcriptional activation of human osteoblasts through the p38 system [ 17 , 24 , 25 , 26 ]. According to the present study, the pathogenesis of osteomyelitis of the jaw—which is known to be induced by a mixed infection, where bone resorption and osteosclerotic lesions are combined—is mediated at least in part by the activation of IL-6 and p38 signaling.…”

Section: Discussionmentioning

confidence: 99%

Lipoteichoic Acid and Lipopolysaccharides Are Affected by p38 and Inflammatory Markers and Modulate Their Promoting and Inhibitory Effects on Osteogenic Differentiation

Ishihata

Seong

Kibe

et al. 2022

IJMS

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Lipoteichoic acid (LTA) and lipopolysaccharide (LPS) are cell wall components of Gram-positive and Gram-negative bacteria, respectively. Notably, oral microflora consists of a variety of bacterial species, and osteomyelitis of the jaw caused by dental infection presents with symptoms of bone resorption and osteosclerosis. However, the effects of LTA and LPS on osteogenic differentiation have not yet been clarified. We examined the effects of LTA and LPS on osteoblasts and found that LTA alone promoted alizarin red staining at low concentrations and inhibited it at high concentrations. Additionally, gene expression of osteogenic markers (ALP, OCN, and OPG) were enhanced at low concentrations of LTA. High concentrations of LPS suppressed calcification potential, and the addition of low concentrations of LTA inhibited calcification suppression, restoring the gene expression levels of suppressed bone differentiation markers (ALP, BSP, and OCN). Moreover, the suppression of p38, a signaling pathway associated with bone differentiation, had opposing effects on gene-level expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), suggesting that mixed LTA and LPS infections have opposite effects on bone differentiation through concentration gradients, involving inflammatory markers (TNF-α and IL-6) and the p38 pathway.

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The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation

Wei,

Shen,

Zhu

et al. 2023

International Immunopharmacology

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Inflammation promotes erythropoietin induced vascular calcification by activating p38 pathway

Cited by 4 publications

References 43 publications

A local-saturation-and-delay MRI method for evaluation of red blood cells aggregation in vivo for tumor-bearing or drug-used rats

A local-saturation-and-delay MRI method for evaluation of red blood cells aggregation in vivo for tumor-bearing or drug-used rats

Lipoteichoic Acid and Lipopolysaccharides Are Affected by p38 and Inflammatory Markers and Modulate Their Promoting and Inhibitory Effects on Osteogenic Differentiation

The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation

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