Inflammation of unknown origin versus fever of unknown origin: Two of a kind

Vanderschueren, Steven; Biondo, Elke Del; Ruttens, David; Boxelaer, Inge Van; Wauters, Els; Knockaert, Daniël

doi:10.1016/j.ejim.2009.01.002

Cited by 84 publications

(83 citation statements)

References 18 publications

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“…This is supported by different studies on fever of unknown origin and inflammation of unknown origin. In a study of Vanderschueren et al, 18 F-FDG PET contributed to the diagnosis in about a third of the patients in both groups [53]. This is comparable to the contribution of 18 F-FDG PET found in other studies on fever of unknown origin [54][55][56].…”

Section: Discussionsupporting

confidence: 55%

Parameters related to a positive test result for FDG PET(/CT) for large vessel vasculitis: a multicenter retrospective study

et al. 2012

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The purpose of this study was to identify clinical and laboratory parameters that may improve the effectiveness of the use of fluorodeoxyglucose positron emission tomography ((18)F-FDG PET)(/CT) for diagnosing large vessel vasculitis (LVV), and secondarily to assess the contribution of (18)F-FDG PET/CT in finding other diagnoses for patients without signs of LVV on the scan. A multicenter retrospective study of (18)F-FDG PET(/CT) scans performed between January 2000 and December 2009 for clinical suspicion of LVV was conducted. A total of 304 (18)F-FDG PET(/CT) scans were included, of which 62 (20%) were positive and 242 (80%) were negative for LVV. Univariate analysis showed that patients with a positive scan were older (65.9 ± 13.4 versus 58.6 ± 16.5 years, p = 0.002), were more frequently female (76% versus 55%, p = 0.002), more often had a history of temporal arteritis (10% versus 3%, p = 0.044), less frequently had artralgia (31% versus 67%, p = 0.000), and had higher thrombocyte counts (434 ± 161 versus 373 ± 168 × 10(9)/l, p = 0.049) and a higher erythrocyte sedimentation rate (ESR) (72.6 ± 31.0 versus 51.4 ± 30.5 mm/h, p = 0.001) than patients with a negative scan. In the multivariate analysis, only artralgia (OR 0.091; 95% CI 0.023-0.366) and ESR (OR 1.024; 95% CI 1.002-1.046) remained statistically significant predictors. The presence of artralgia is a statistically significant negative predictor and an elevated ESR a statistically significant positive predictor of LVV showing up on (18)F-FDG PET(/CT). A reliable prediction of the outcome of the scan, based on these two parameters, is not possible however. (18)F-FDG PET(/CT) allows early diagnosis of LVV and may discover occult inflammatory or neoplastic disorders.

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Section: Discussionsupporting

confidence: 55%

Parameters related to a positive test result for FDG PET(/CT) for large vessel vasculitis: a multicenter retrospective study

et al. 2012

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“…2 Inflammation of unknown origin without fever and FUO may reflect differences in clinical presentation of the same disease entities. 3 In search for an explanation of IUO, patients may therefore undergo extensive and expensive investigations and medical treatment. Interventions that may not only be inappropriate but at the same time unnecessary expose patients to the risks of these investigations.…”

mentioning

confidence: 99%

Diagnostic Utility of 18F-FDG PET/CT in Inflammation of Unknown Origin

Balink¹,

Bennink²,

Veeger³

et al. 2014

Clinical Nuclear Medicine

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“…La stratégie diagnostique devant un syndrome inflammatoire biologique d'origine indéterminée ne diffère guère de la stratégie diagnostique devant une fièvre prolongée inexpliquée [2]. La TEP-FDG dans ces deux situations semble avoir un Presse Med.…”

Section: Discussionunclassified

“…La TEP-FDG dans ces deux situations semble avoir un Presse Med. 2011; 40: 651-653 en ligne sur / on line on www.em-consulte.com/revue/lpm www.sciencedirect.com intérêt pour le diagnostic étiologique [2]; toutefois les études cliniques sont en cours pour en valider l'indication dans ces situations notamment d'un point de vue médico-économique. L'utilité de la TEP-FDG pour l'évaluation diagnostique des phéochromocytomes et paragangliomes a été récemment soulignée [3].…”

Section: Discussionunclassified