Inflammation of the Pleural Cavity: A Review on Pathogenesis, Diagnosis and Implications in Tumor Pathophysiology

Karpathiou, Georgia; Péoc’h, Michel; Sundaralingam, Anand; Rahman, Najib M.; Froudarakis, Marios

doi:10.3390/cancers14061415

Cited by 11 publications

(8 citation statements)

References 104 publications

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“…For instance, acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are inflammatory pulmonary disorders where damage to the alveolar–capillary barrier leads to the release of neutrophil granules and oxidative injury [ 41 , 42 ]. Additionally, some of the causes of pleurisy, a condition where the layers separating the lungs from the chest are injured, are also related to inflammation [ 43 ]. Excessive and chronic inflammation in the lungs can be life-threatening, given the vital role of this organ.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Silva,

Pinheiro,

Ombredane

et al. 2023

Pharmaceuticals

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Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Silva,

Pinheiro,

Ombredane

et al. 2023

Pharmaceuticals

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“…Blintcliffe et al suggested that pleurodesis may be the last choice in benign pleural or suspected malignant effusion treated with an indwelling pleural catheter without observed benefits [ 86 ]. At the same time, in vitro observations suggest that maintaining an ongoing pleural effusion may help cancer cells to survive and develop [ 87 , 88 ].…”

Section: Talc: the Potential Link Between Mesothelial Hyperplasia And...mentioning

confidence: 99%

Diagnostic and Therapeutic Challenges of Malignant Pleural Mesothelioma

et al. 2022

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Malignant pleural mesothelioma is a rare cancer characterized by a very poor prognosis. Exposure to asbestos is the leading cause of malignant pleural mesothelioma. The preinvasive lesions, the mesothelial hyperplasia and its possible evolution are the focus of the majority of the studies aiming to identify the treatable phase of the disease. The role of BAP-1 and MTAP in the diagnosis of mesothelioma in situ and in the prognosis of malignant pleural mesothelioma is the main topic of recent studies. The management of preinvasive lesions in mesothelioma is still unclear and many aspects are the subject of debate. The diagnosis, the disease staging and the accurate, comprehensive assessment of patients are three key instants for an appropriate management of patients/the disease.

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“…IL-6 stimulates the production of extracellular matrix components, such as collagen, leading to fibrotic tissue deposition. Excessive fibrosis can impair organ function and compromise peritoneal dialysis efficiency, and elevated levels of IL-6 have been associated with poor prognosis in peritoneal fibrosis [ 66 , 67 ]. In peritoneal dialysis-associated peritonitis, inflammatory factors and fibrotic mediators reduce the secretion of decorin by peritoneal mesothelial cells (PMCs), causing excessive deposition of fibronectin secreted by PMCs and fibrosis [ 68 – 70 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis

Dadgar,

Sherry,

Zimmerman

et al. 2024

J Transl Med

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Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (sIL-6-Rα) in the peritoneal cavity of patients with PC has highlighted this pathway as an emerging potential therapeutic target. This review article provides a comprehensive overview of the current understanding of the potential role of IL-6 in the development and progression of PC. We discuss mechansims by which the IL-6 pathway may contribute to peritoneal tumor dissemination, mesothelial adhesion and invasion, stromal invasion and proliferation, and immune response modulation. Finally, we review the prospects for targeting the IL-6 pathway in the treatment of PC, focusing on common sites of origin, including ovarian, gastric, pancreatic, colorectal and appendiceal cancer, and mesothelioma.

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Inflammation of the Pleural Cavity: A Review on Pathogenesis, Diagnosis and Implications in Tumor Pathophysiology

Cited by 11 publications

References 104 publications

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Diagnostic and Therapeutic Challenges of Malignant Pleural Mesothelioma

Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis

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