Inflammation of the Dental Pulp

Park, Sang Hyuk; Ye, Ling; Love, Robert M.; Farges, Jean‐Christophe; Yumoto, Hiromichi

doi:10.1155/2015/980196

Cited by 38 publications

(28 citation statements)

References 9 publications

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“…Inflammation of the dental pulp owing to microorganisms from caries, trauma or microleakage around faulty restorations may sequentially stimulate periapical inflammation (Van Hassel , Park et al . ). The inflammatory process is primarily initiated in the infected and necrotic pulp but can then spread into the periapical tissues, which may eventually lead to surrounding bone resorption.…”

Section: Introductionmentioning

confidence: 97%

“…The pathogenesis of apical periodontitis (AP) is mainly due to the host inflammatory response caused by complex microbial infections in the pulp tissue and root canals (Kakehashi et al 1965). Inflammation of the dental pulp owing to microorganisms from caries, trauma or microleakage around faulty restorations may sequentially stimulate periapical inflammation (Van Hassel 1971, Park et al 2015. The inflammatory process is primarily initiated in the infected and necrotic pulp but can then spread into the periapical tissues, which may eventually lead to surrounding bone resorption.…”

Section: Introductionmentioning

confidence: 99%

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The Presence and involvement of interleukin‐17 in apical periodontitis

2019

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Apical periodontitis (AP) is a chronic inflammatory disease characterized by periapical tissue inflammation and destruction of the associated alveolar bone. It is caused by microbial infections within the root canal and the resultant host immune responses in the periapical tissues. The proinflammatory cytokine interleukin (IL)‐17 has been shown to play an important role in many inflammatory diseases. There is increasing evidence of the presence of IL‐17 in AP, which might be associated with disease pathogenesis. Moreover, several animal studies indicate the potential role of IL‐17 in periapical inflammation and the resultant bone resorption in AP. This article reviews recent studies regarding the collective in vitro, in vivo and clinical evidence of the presence and involvement of IL‐17 in AP. A search related to IL‐17 in apical periodontitis was conducted on PubMed, EMBASE and Web of Science databases using keywords and controlled vocabulary. Two independent reviewers first screened titles and abstracts and then the full texts that were included. A total of 25 papers were identified, of the 25 included articles, 7 involved laboratory studies on cell cultures, 11 involved animal experimentations, and 7 were observational studies using human clinical samples. In conclusion, evidence for the presence of IL‐17 in AP from human and animal models is clear. However, there is relatively little information currently available that would highlight the specific role of IL‐17 in AP.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The Presence and involvement of interleukin‐17 in apical periodontitis

2019

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“…[ 1 2 3 4 ] A complete understanding of the pulpal inflammatory process is indispensable in the formulation dental procedures and development immunotherapeutic agents. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

The vital pulp therapy of permanent teeth: A dental practitioner’s perspective from Saudi Arabia

Doumani¹,

Arnous²,

Alsafadi³

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Aims and Objectives: The aim of this study was to determine the levels of knowledge and attitude of dental practitioners (DPs) toward vital pulp therapy (VPT) of young permanent teeth in Riyadh city, Saudi Arabia. Materials and Methods: A descriptive cross-sectional study was carried out by taking convenient sample of general DPs and specialist attending Saudi International Dental Conference, Riyadh, Saudi Arabia. A total of 200 DPs administered a structured, self-administered questionnaire to evaluate their knowledge and attitude toward VPT. The questionnaire comprised four parts: Part I: Characteristics of the study participants; Part II: Items related to indications and diagnosis of VPT; Part III: Questions related to the different VPTs for immature permanent teeth; and Part IV: Dental materials used in VPT and restoration. All the data were entered into the statistical analysis software Statistical Package for the Social Sciences version 21.0 (IBM, Armonk, NY) and analyzed by using descriptive statistics of frequency distribution and percentages for the categorical variables. Results: A total of 193 (men = 57% [110] and women = 43% [83]) DPs participated in this study with a response rate of 96.5%. Less than half of correct responses were observed with (Item 1) related to the duration of complete closure of root apex (43%) and (Item 14) use of sodium hypochlorite to serve as an excellent diagnostic tool to differentiate irreversible from reversible pulpitis. A high percentage of correct responses were seen with the (Item 9) indirect pulp capping––a procedure performed in a tooth with a deep carious lesion without signs or symptoms of pulp degeneration (75%). All other item responses ranged in between 52% and 72%. Conclusion: DPs showed fair-to-good knowledge and attitude toward VPT of young permanent teeth. In general, there is a need to improve knowledge and attitude of dental professionals about the VPT by attending continuing dental educational programs.

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“…Pulpitis is a common inflammatory disease of the dental pulp and is usually induced by bacterial infection and the local accumulation of inflammatory factors (Hui et al 2017) and can cause severe pain and damage to the pulp tissue (Park et al 2015). Human dental pulp cells (hDPCs) are often used as models for investigating the pathology of pulpitis (Kang et al 2017) and play an important role in inflammatory response, regeneration and the pulp tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide‐induced DNA damage response activates nuclear factor κB signalling pathway via GATA4 in dental pulp cells

et al. 2019

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Aim To investigate the role of GATA‐binding protein 4 (GATA4) in the inflammatory response induced by DNA double‐strand breaks (DSBs) in human dental pulp cells (hDPCs). Methodology Lipopolysaccharide (LPS) was used for stimulating inflammation in dental pulp tissue in vivo and hDPCs in vitro. Expression levels of GATA4 and γ‐H2A.X (a marker for DSBs) were detected at different stages of pulpitis in a rat model and human pulp tissues by immunohistochemistry. Real‐time quantitative polymerase chain reaction and Western blot were performed to assess expression of GATA4 and γ‐H2A.X and the activation of nuclear factor κB (NF‐κB) in hDPCs stimulated by LPS. The comet assay was used for detecting the extent of DSBs in hDPCs. Immunocytochemistry and Western blot were utilized to evaluate expression of γ‐H2A.X and GATA4 and activation of NF‐κB in hDPCs pre‐treated with inhibitors of DNA damage response or transfected with GATA4 small interfering RNA before the treatment of LPS. Data were analysed statistically using one‐way anova or Kruskal–Wallis tests. Results The expression of GATA4 and activation of DNA damage response and NF‐κB in inflamed pulp tissue and LPS‐treated hDPCs were identified. Significantly decreased expression of GATA4 and significantly decreased inflammatory processes in hDPCs were demonstrated via suppression of DNA damage response (P < 0.05). In GATA4‐knockdown cells, the expression of γ‐H2A.X did not change, but nuclear translocation of p65 was significantly suppressed (P < 0.05) upon induction by LPS. Conclusions Lipopolysaccharide‐induced DSBs activated the NF‐κB signalling pathway in hDPCs, and GATA4 acts as a positive moderator of the progress. The involvement of GATA4 in this pathology may serve as a therapeutic target in pulpitis.

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Inflammation of the Dental Pulp

Cited by 38 publications

References 9 publications

The Presence and involvement of interleukin‐17 in apical periodontitis

The Presence and involvement of interleukin‐17 in apical periodontitis

The vital pulp therapy of permanent teeth: A dental practitioner’s perspective from Saudi Arabia

Lipopolysaccharide‐induced DNA damage response activates nuclear factor κB signalling pathway via GATA4 in dental pulp cells

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