Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation

Kusayama, Takashi; Furusho, Hiroshi; Kashiwagi, Haruka; Kato, Takeshi; Murai, Hisayoshi; Usui, Soichiro; Kaneko, Shuichi; Takamura, Masayuki

doi:10.1016/j.jjcc.2015.11.005

Cited by 42 publications

(29 citation statements)

References 30 publications

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“…Indeed, the post-CA adaptive processes lead to electro-anatomical alterations in atrial myocardium that may be functionally implicated in AF recurrence. 18 Supporting this view, corticosteroids have been proposed as a therapeutic approach to prevent AF recurrence following CA. 19 In our study, ALA therapy led to a significant reduction of inflammatory stress in ablated patients.…”

Section: Discussionmentioning

confidence: 99%

“…These results indicate that ALA cannot prevent or revert the post-CA fibrotic and remodeling processes altering atrial shape and function. 12,18,23 Such electro-anatomic remodeling affects the genesis, duration and propagation of action potentials in the atria, 24–27 {Santulli, 2014 #337} rendering the tissue more susceptible to factors triggering arrhythmias. 28,29 Therefore, the effects of ALA on cellular cardiac membrane and sympathetic function do not influence the fibrotic remodeling observed in AF recurrences.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation

Sardu

Santulli

Santamaria³

et al. 2017

The American Journal of Cardiology

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Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral anti-oxidant treatment (α-lipoic acid, ALA) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double blind, controlled placebo trial. Following CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group), and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33; control: 40). No significant difference has been detected between the two groups at baseline. Strikingly, one year after CA, ALA therapy significantly reduced serum markers of inflammation. However, there was no significant difference in AF recurrence events at follow-up when comparing ALA to placebo group. Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence post-CA is age. In conclusion, ALA therapy reduces serum levels of common markers of inflammation in ablated patients. Nevertheless, ALA does not prevent AF recurrence after an ablative treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation

Sardu

Santulli

Santamaria³

et al. 2017

The American Journal of Cardiology

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“…CD40 ligand (CD40L), a sensitive indicator of inflammation associated platelet activation, was recently found to be significantly higher in NVAF but only during the first year of this dysrhythmia . Whether this time‐dependent variation also exists for other inflammation and prothrombotic biomarkers including VWF in NVAF patients remains essentially unexplored …”

Section: Introductionmentioning

confidence: 99%

Effect of atrial fibrillation duration on plasma von Willebrand factor level

Wysokiński

Cohoon

Konik

et al. 2017

European J of Haematology

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“…It is not yet clear which of the cohort of paracrine messengers cause particular pathological changes in cardiac myocytes. Moreover, it has been demonstrated that the secretome of adipocytes can change under pathological conditions such as inflammation, thereby promoting the release of harmful signals (Kusayama et al, ; Venteclef et al, ; Furuhashi et al, ; Iacobellis, ). Adipokines have been linked to many pathologies (Deng and Scherer, ), but the mechanisms involved remain to be elucidated.…”

Section: Overview Of Adipokinesmentioning

confidence: 99%

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?

Rietdorf

MacQueen

2017

British J Pharmacology

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Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological interventions for their management. More targeted and less invasive therapies would be beneficial. Recently it has become apparent that epicardial adipose tissue plays an important role in normal and pathological cardiac function, and it is now the focus of considerable research. Epicardial adipose tissue can be studied by imaging of various kinds, and these approaches have yielded much useful information. However at a molecular level it is more difficult to study as it is relatively scarce in animal models and, for practical and ethical reasons, not always available in sufficient quantities from patients. What is needed is a robust model system in which the interactions between epicardial adipocytes and cardiac myocytes can be studied, and physiologically relevant manipulations performed. There are drawbacks to conventional culture methods, not least the difficulty of culturing both cardiac myocytes and adipocytes, each of which has special requirements. We discuss the benefits of a three-dimensional coculture model in which in vivo interactions can be replicated. EAT and cardiac myocytesThis article is protected by copyright. All rights reserved.

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Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation

Cited by 42 publications

References 30 publications

Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation

Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation

Effect of atrial fibrillation duration on plasma von Willebrand factor level

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?

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