Inflammation neuroscience: neuro‐immune crosstalk and interfaces

Tarnawski, Laura; Olofsson, Peder S.

doi:10.1002/cti2.1352

Cited by 16 publications

(9 citation statements)

References 105 publications

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“…In conclusion, the studies conducted in conscious experimental models demonstrate the value of methodological approaches used to investigate cardiovascular reflexes in rats and mice for investigating the neural mechanisms involved in inflammatory responses [4, 6, 7, 48, 67–69, 75, 80]. This is particularly relevant as most studies on neuromodulation of inflammation were usually conducted in anesthetized animals.…”

Section: Discussionmentioning

confidence: 95%

“…Classically, the immune system is modulated by humoral factors such as cytokines, catecholamines, and hormones. However, more recent studies have shown that the nervous system regulates the immune system through specific neuronal networks [1–4]. Afferent (sensory) and efferent (effector) fibers of the vagus nerve connect the brain with the peripheral immune system [1, 3, 5].…”

Section: Introductionmentioning

confidence: 99%

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Autonomic Regulation of Inflammation in Conscious Animals

Salgado,

Brognara,

Ribeiro

et al. 2023

Neuroimmunomodulation

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Bioelectronic medicine is a novel field in modern medicine based on the specific neuronal stimulation to control organ function, cardiovascular, and immune homeostasis. However, most studies addressing neuromodulation of the immune system have been conducted on anesthetized animals, which can affect the nervous system and neuromodulation. Here, we review recent studies involving conscious experimental rodents (rats and mice) to better understand the functional organization of neural control of immune homeostasis. We highlight typical experimental models of cardiovascular regulation, such as electrical activation of the aortic depressor nerve or the carotid sinus nerve, bilateral carotid occlusion, the Bezold-Jarisch reflex, and intravenous administration of the bacterial endotoxin lipopolysaccharide. These models have been used to investigate the relationship between neuromodulation of the cardiovascular and immune systems in conscious rodents (rats and mice). These studies provide critical information about the neuromodulation of the immune system, particularly the role of the autonomic nervous system, i.e., the sympathetic and parasympathetic branches acting both centrally (hypothalamus, nucleus ambiguus, nucleus tractus solitarius, caudal ventrolateral medulla, and rostral ventrolateral medulla), and peripherally (particularly spleen and adrenal medulla). Overall, the studies in conscious experimental models have certainly highlighted to the reader how the methodological approaches used to investigate cardiovascular reflexes in conscious rodents (rats and mice) can also be valuable for investigating the neural mechanisms involved in inflammatory responses. The reviewed studies have clinical implications for future therapeutic approaches of bioelectronic modulation of the nervous system to control organ function and physiological homeostasis in conscious physiology.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Autonomic Regulation of Inflammation in Conscious Animals

Salgado,

Brognara,

Ribeiro

et al. 2023

Neuroimmunomodulation

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“…For this to happen, molecules exist which mediate the various phases, creating a tightly regulated system involving different tissues, cell types, cytokines, and receptors. Their impact on the acute inflammation spectrum largely depends on the phase of the inflammatory response [ 4 ], cell-type composition, tissue microenvironment [ 35 , 36 ], including their crosstalk with the peripheral nervous system [ 37 ]. Conversely, there is no clear distinction between “friends” and “foes” in the molecular landscape of inflammatory processes as their roles can even be reversed in a spatiotemporal context [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

et al. 2023

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Background Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation involves multiple cell types and various processes. We, therefore, investigated whether an immunomodulatory drug that acts simultaneously at multiple sites shows greater potential to resolve acute inflammation more effectively and with fewer side effects than a common anti-inflammatory drug developed as a small molecule for a single target. In this work, we used time-series gene expression profiles from a wound healing mouse model to compare the effects of Traumeel (Tr14), a multicomponent natural product, to diclofenac, a single component NSAID on inflammation resolution. Results We advance previous studies by mapping the data onto the “Atlas of Inflammation Resolution”, followed by in silico simulations and network analysis. We found that Tr14 acts primarily on the late phase of acute inflammation (during resolution) compared to diclofenac, which suppresses acute inflammation immediately after injury. Conclusions Our results provide new insights how network pharmacology of multicomponent drugs may support inflammation resolution in inflammatory conditions.

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“…For example, anti-inflammatory effects are mediated by β2-adrenergic receptors; in contrast, α-adrenergic receptors on monocytes and macrophages can cause an increase in the production of pro-inflammatory cytokines, such as TNF-α. Cholinergic fibers releasing acetylcholine, on the other hand, can moderate inflammation; the same effects can be caused by acetylcholine-producing B e T cells [ 42 ].…”

Section: Psyche and Biological Systems: The Bidirectional Pathwaysmentioning

confidence: 99%

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

Bottaccioli

Bologna

Bottaccioli

2022

IJMS

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Today, it is possible to investigate the biological paths and mechanisms that link mental life to biological life. Emotions, feelings, desires, and cognitions influence biological systems. In recent decades, psychoneuroendocrinoimmunology research has highlighted the routes linking the psyche–brain–immune systems. Recently, epigenetics research has shown the molecular mechanisms by which stress and mental states modulate the information contained in the genome. This research shapes a new paradigm considering the human being as a whole, integrating biology and psychology. This will allow us to progress towards personalized precision medicine, deeply changing medical and psychological sciences and clinical practice. In this paper, we recognize leading research on both bidirectional relations between the psyche–brain–immunity and molecular consequences of psychological and mental states.

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Inflammation neuroscience: neuro‐immune crosstalk and interfaces

Cited by 16 publications

References 105 publications

Autonomic Regulation of Inflammation in Conscious Animals

Autonomic Regulation of Inflammation in Conscious Animals

Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

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