Inflammation markers on benign breast biopsy are associated with risk of invasive breast cancer in African American women

Shaik, Asra N.; Kiavash, Katrin; Stark, Karri; Boerner, Julie L.; Ruterbusch, Julie J.; Deirawan, Hany; Bandyopadhyay, Sudeshna; Ali-Fehmi, Rouba; Dyson, Gregory; Coté, Michele L.

doi:10.1007/s10549-020-05983-x

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Unfortunately, studies investigating the association between BMI and CLS presence in non-breast-cancer patients are sparse. Two smaller case-control studies in patients with benign breast disease (BBD) showed conflicting results, with one reporting a positive correlation between CLS presence and BMI and the other reporting no significant association [ 124 , 125 ]. Furthermore, the positive correlation between CLS and BMI reported by Carter et al [ 124 ] was mainly driven by the patients with BBD, indicating a strong need for studies investigating the association between CLS and BMI in patients without a breast disease.…”

Section: Breast Cancer Progression and Local Obesity-associated Biomarkersmentioning

confidence: 99%

Local Biomarkers Involved in the Interplay between Obesity and Breast Cancer

Holm

Rosendahl

Borgquist

2021

Cancers

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Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non-melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abundant in the breast. Therefore, breast cancer develops in an adipose-rich environment. During obesity, changes in the local environment in the breast occur which are associated with breast cancer. A shift towards a pro-inflammatory state is seen, resulting in altered levels of cytokines and immune cells. Levels of adipokines, such as leptin, adiponectin, and resistin, are changed. Aromatase activity rises, resulting in higher levels of potent estrogen in the breast. Lastly, remodeling of the extracellular matrix takes place. In this review, we address the current knowledge on the changes in the breast adipose tissue in obesity associated with breast cancer initiation and progression. We aim to identify obesity-associated biomarkers in the breast involved in the interplay between obesity and breast cancer. Hereby, we can improve identification of women with obesity with an increased risk of breast cancer and an impaired prognosis. Studies investigating mammary adipocytes and breast adipose tissue in women with obesity versus women without obesity are, however, sparse and further research is needed.

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Section: Breast Cancer Progression and Local Obesity-associated Biomarkersmentioning

confidence: 99%