Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease

Safranow, Krzysztof; Dziedziejko, Violetta; Rzeuski, Ryszard; Czyżycka, Edyta; Bukowska, H.; Wojtarowicz, Andrzej; Bińczak-Kuleta, Agnieszka; Jakubowska, Katarzyna; Olszewska, Maria; Ciechanowicz, Andrzej; Kornacewicz-Jach, Zdzisława; Pawlik, Andrzej; Chlubek, Dariusz

doi:10.5604/17322693.1194612

Cited by 22 publications

(23 citation statements)

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“…7 A plethora of evidence confirmed the potency of members of family long PTX (PTX-3) in promoting atherosclerosis. 10,11 Up to the present, reduction of low-density lipoprotein, application of anticoagulant drugs, percutaneous coronary intervention, and coronary artery bypass surgery have been considered as routine therapies for atherosclerosis. 9 An increased level of IL-6 during atherosclerotic exacerbates the pathological outcomes, and reduction of this interleukin has been shown to yield therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

“…9 An increased level of IL-6 during atherosclerotic exacerbates the pathological outcomes, and reduction of this interleukin has been shown to yield therapeutic effects. 10,11 Up to the present, reduction of low-density lipoprotein, application of anticoagulant drugs, percutaneous coronary intervention, and coronary artery bypass surgery have been considered as routine therapies for atherosclerosis. 12 In spite of these modulations, many attempts have been focused on the application of natural compound and alternative medicine.…”

Section: Introductionmentioning

confidence: 99%

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Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro

Karbasforush

Nourazarian

Darabi

et al. 2018

Cell Biochemistry & Function

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The current experiment showed that docosahexaenoic acid could reverse atherosclerotic changes in human endothelial cells induced by palmitic acid. The increased levels of interleukin-6 and prostaglandin E in atherosclerotic cells were returned to near-to-normal status. Gene expression analysis showed a reduced activity of genes participating in atherosclerotic endothelial cells treated by docosahexaenoic acid. The expression of genes related to cell clotting activity was also similar to that of normal cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro

Karbasforush

Nourazarian

Darabi

et al. 2018

Cell Biochemistry & Function

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“…Multiple studies have found a significant association between inflammation and increased risk of malignant arrhythmias . Safranow et al demonstrated significantly higher levels of high‐sensitivity C‐reactive protein and interleukin‐6 levels in patients with coronary artery disease who experienced sustained VT and VF. Tung et al found that nearly 50% of patients with unexplained cardiomyopathy and VAs had ongoing focal myocardial inflammation on positron emission tomography/computed tomography.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have found a significant association between inflammation and increased risk of malignant arrhythmias. 29 Safranow et al 30 patients with chronic ICMP and found that these cells were not associated with an increased risk of arrhythmic events. The same was true for the MSCs, which were not associated with an increase in the arrhythmic events in a short-or long-term follow-up 33 and seemed to have a potential antiarrhythmic effect reported by Ramireddy et al 34 Skeletal myoblast therapy has shown pro-arrhythmia responses, which was documented in clinical studies but not in controlled trials.…”

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confidence: 99%

A meta‐analysis of arrhythmia endpoints in randomized controlled trials of transendocardial stem cell injections for chronic ischemic heart disease

Fernandes

Rivera

et al. 2019

Cardiovasc electrophysiol

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Introduction The electrophysiologic impact of cell‐based therapy on the injured myocardium remains highly controversial. We aimed to perform a meta‐analysis of studies comparing arrhythmia burden following transendocardial stem cell therapy vs placebo in patients with chronic ischemic heart disease (CIHD). Methods and Results PubMed, Embase, and Cochrane Central Register of Controlled Trials were searched. No restriction of stem cell type was specified. The outcomes included sustained supraventricular or ventricular arrhythmias (VAs), sudden cardiac death (SCD), and resuscitated sudden cardiac arrest (SCA). Effect sizes were reported as odds ratio (OR) and 95% CI. Poisson regression was used to account for zero‐events data. Twelve randomized trials that included 736 patients (384 in the cell therapy group and 352 in the placebo group) were analyzed. Six different cell types were used. Follow‐up ranged from 6 to 12 months. There was a significant decrease in risk of SCD in the cell therapy group, (FE OR, 0.19 [0.04, 0.93]; P = .04). In subgroup analysis, there was a significantly lower risk of SCD or resuscitated SCA in the cell therapy group limited to studies that did not use skeletal myoblasts, (FE OR, 0.23 [0.06, 0.83]; P = .03). There was no significant difference in the incidence of sustained VA between groups (FE OR, 0.91 [0.47, 1.77]; P = .8), even after stratifying by cell type. There was no difference in supraventricular arrhythmias between groups. Conclusion Nonskeletal myoblast transendocardial cell therapy was associated with a significantly lower risk of SCD or resuscitated SCA compared to control, with no proarrhythmic effects.

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“…Another important pathophysiological mechanism of AMIinduced VAs is the activation of the immune system and the release of proinflammatory cytokines. 29,30 proinflammatory cardiac cytokines were significantly increased in the acute phase after AMI. 31 IL-18 and IL-1β, as members of the proinflammatory IL-1 cytokine family, play key roles in the development of cardiac dysfunction.…”

Section: Neuroimmune Response and Post-ami Vasmentioning

confidence: 93%

Noninvasive light emitting diode therapy: A novel approach for postinfarction ventricular arrhythmias and neuroimmune modulation

Wang

Zhai

et al. 2019

Cardiovasc electrophysiol

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Background: Sympathetic neural activation plays a key role in the incidence and maintenance of acute myocardial infarction (AMI) induced ventricular arrhythmia (VA). Furthermore, previous studies showed that AMI might induce microglia and sympathetic activation and that microglial activation might contribute to sympathetic activation. Recently, studies showed that light emitting diode (LED) therapy might attenuate microglial activation. Therefore, we hypothesized that LED therapy might reduce AMI-induced VA by attenuating microglia and sympathetic activation.Methods: Thirty anesthetized rats were randomly divided into three groups: the Control group (n = 6), AMI group (n = 12), and AMI + LED group (n = 12). Electrocardiogram (ECG) and left stellate ganglion (LSG) neural activity were continuously recorded. The incidence of VAs was recorded during the first hour after AMI.Furthermore, we sampled the brain and myocardium tissue of the different groups to examine the microglial activation and expression of nerve growth factor (NGF), interleukin-18 (IL-18), and IL-1β, respectively.Results: Compared to the AMI group, LED therapy significantly reduced the incidence of AMI-induced VAs (ventricular premature beats [VPB] number: 85.08 ± 13.91 vs 27.5 ± 9.168, P < .01; nonsustained ventricular tachycardia (nSVT) duration: 34.39 ± 8.562 vs 9.005 ± 3.442, P < .05; nSVT number: 18.92 ± 4.52 vs 7.583 ± 3.019, P < .05; incidence rate of SVT/VF: 58.33% vs. 8.33%, P < .05) and reduced the LSG neural activity (P < .01) in the AMI + LED group. Furthermore, LED significantly attenuated microglial activation and reduced IL-18, IL-1β, and NGF expression in the peri-infarct myocardium.Conclusion: LED therapy may protect against AMI-induced VAs by suppressing sympathetic neural activity and the inflammatory response.

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Inflammation markers are associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease

Abstract: WBC, CRP and IL-6 are strongly associated with components of the metabolic syndrome. Their strong association with life-threatening ventricular arrhythmia emphasizes the proarrhythmic role of inflammation in the increased cardiovascular risk of CAD patients.

Cited by 22 publications

References 0 publications

Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro

Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro

A meta‐analysis of arrhythmia endpoints in randomized controlled trials of transendocardial stem cell injections for chronic ischemic heart disease

Noninvasive light emitting diode therapy: A novel approach for postinfarction ventricular arrhythmias and neuroimmune modulation

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