Inflammation

Steinhoff, M.; Griffiths, Chris; Church, M. K.; Luger, T. A.

doi:10.1002/9780470750520.ch9

Cited by 3 publications

(2 citation statements)

References 509 publications

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“…Consequently, neutrophils need to be recruited to the site of inflammation very rapidly. During disease state, molecules exist which may support or counteract this capability (52). Thus, proteases released by endothelial cells, mast cells or neutrophils themselves may be involved in the pathophysiology of cutaneous inflammation and sepsis in humans by affecting neutrophil apoptosis, transendothelial migration and Fcγ receptor‐mediated phagocytosis.…”

Section: Discussionmentioning

confidence: 99%

Agonists of proteinase‐activated receptor‐2 affect transendothelial migration and apoptosis of human neutrophils

Shpacovitch

Seeliger

Huber‐Lang

et al. 2007

Experimental Dermatology

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Skin is the first barrier preventing microorganism invasion in host. Wounds destroy this defense barrier and, without an appropriate care, may lead to sepsis. Neutrophil activation and immigration plays an important role at the inflammatory stage of wound healing. Neutrophils are known to express proteinase-activated receptors (PARs), which can be activated by serine proteases, also by enzymes involved in wound healing. We previously reported that PAR(2) agonists up-regulate cell adhesion molecule expression and cytokine production by human neutrophils. Here, we demonstrate that PAR(2) agonists (serine proteases as well as synthetic peptides) reduce transendothelial migration of neutrophils and prolong their life in vitro. Synthetic PAR(2) agonist also enhanced protective interferon (IFN)gamma-induced FcgammaRI expression at neutrophil cell surface. Of note, IFNgamma is a cytokine, which was used in clinical trials to reactivate human neutrophil functions during sepsis. Moreover, we observed a significant increase of PAR(2) expression on cell surface of neutrophils from septic patients as compared with healthy volunteers. Together, our results indicate that PAR(2) may be involved in the pathophysiology of neutrophil-endothelial interactions during wound healing or later during sepsis in humans, potentially by affecting neutrophil apoptosis, transendothelial migration and Fcgamma receptor-mediated phagocytosis.

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Section: Discussionmentioning

confidence: 99%

Agonists of proteinase‐activated receptor‐2 affect transendothelial migration and apoptosis of human neutrophils

Shpacovitch

Seeliger

Huber‐Lang

et al. 2007

Experimental Dermatology

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“…The rationale to use antifungals in LP is based on the knowledge that most antifungals, similar to antibiotics and antiparasitics, present to a certain extent anti‐inflammatory capacities . In LP, most studies data exist for griseofulvin or itraconazole.…”

Section: Systemic Antifungalsmentioning

confidence: 99%

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Husein‐ElAhmed

Gieler

Steinhoff

2019

Acad Dermatol Venereol

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Lichen planus (LP) is a chronic-relapsing inflammatory skin disease. Although many drugs have been used for the management of LP, some of them lack the backup by strong therapeutic evidence, while others are not suitable for some patients due to safety profile issues. The aim of this study was to review the recent status of available medical therapies for LP to help physicians make better decisions upon best medical practice while facing patients with this condition. A review of published articles on management of LP was conducted with the MEDLINE and PubMed databases. The quality of the evidence was graded as high, moderate, low or very low. A total of 1366 articles were retrieved, and 219 (16%) were included in the final analysis. Twenty-one different treatment modalities were analysed. The quality of evidence was high for topical steroid and calcineurin inhibitor, while it was moderate for oral steroids. All the other modalities reached low or very low quality of evidence. Topical steroids and calcineurin inhibitors are the current first-line therapies, while for other therapies the strength of recommendation is not so evident. Unfortunately, larger randomized, controlled trials to support the efficacy, safety and tolerability of other therapies in LP are lacking, and many of them are recommended based on studies with small sample sizes, lack of standardized outcome measures or lack of controlled duration or even in anecdotal evidence. Thus, large-scale randomized clinical trials are still warranted to establish the exact benefits of other topical treatments, phototherapy, immunosuppressant and new immunomodulators for an optimized treatment of LP.

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Antioxidant and inhibition of senescence effects of embelin

Ahn

Yong

2018

biomed dermatol

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Background: Embelin is a major active ingredient of Embelia ribes Burm. belonging to Myrsinaceae, an important traditional medicinal plant of Indian origin. Embelin has a benzoquinone derivative structure and has been studied for anticancer, anti-inflammatory, and antioxidative effects. However, there have been no studies on the use of cosmetic raw materials for embelin. In this study, antioxidant and inhibition of senescence effects of embelin were examined using hydrogen peroxide (H 2 O 2)-induced cellular aging model of human dermal fibroblast. Methods: Cell viability was measured using the principle of water-soluble tetrazolium salt (WST-1) assay. qRT-PCR was used to quantitatively analyze gene expression patterns in human dermal fibroblasts (HDFs) by embelin. Dichlorofluorescein diacetate (DCF-DA) was used to measure changes in intracellular reactive oxygen species (ROS) concentration. Cell senescence was measured using the senescence-associated β-galactosidase (SA-β-galactosidase) assay, a method of staining β-galactosidase. A wound healing assay was used to observe cell mobility. Results: The WST-1 assay demonstrated that decreased cell viability by H 2 O 2 was restored by embelin in a dose-dependent manner. In addition, the expression of SOD1, GPx1, and CAT genes were upregulated by embelin suggesting that embelin-induced antioxidant capability may be enhanced through the upregulation of intracellular antioxidant-related genes. To determine whether embelin inhibits cell senescence in H 2 O 2-induced senescence model of HDFs, the SA-β-galactosidase assay was performed. Embelin decreased the SA-β-galactosidase activity in a dose-dependent manner in H 2 O 2-treated HDFs. Moreover, the expression of p21 and MMP1 genes were reduced by embelin in H 2 O 2-treated HDFs in a dose-dependent manner. However, COL1A1 genes were increased by embelin in H 2 O 2-treated HDFs in a dose-dependent manner. Conclusions: These results suggest that embelin has a potential as an antiaging cosmetic ingredient with antioxidant and anti-senescence properties.

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Inflammation

Cited by 3 publications

References 509 publications

Agonists of proteinase‐activated receptor‐2 affect transendothelial migration and apoptosis of human neutrophils

Agonists of proteinase‐activated receptor‐2 affect transendothelial migration and apoptosis of human neutrophils

Lichen planus: a comprehensive evidence‐based analysis of medical treatment

Antioxidant and inhibition of senescence effects of embelin

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