Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI

Tang, Guixian; Chen, Pan; Chen, Guanmao; Zhong, Shuming; Gong, Jiaying; Zhong, Hui; Ye, Tao; Chen, Feng; Wang, Jurong; Luo, Zhenye; Qi, Zhangzhang; Jia, Yanbin; Wang, Ying; Huang, Li

doi:10.1017/s003329172100009x

Cited by 18 publications

(25 citation statements)

References 100 publications

(115 reference statements)

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“…Despite this, it is clear that the vast majority of significant functional MRI findings are found in regions involved in emotion regulation (e.g. amygdala, insula, temporal or prefrontal areas (Barzman et al, 2014;Furlan et al, 2019;Tseng et al, 2021;Tu et al, 2017)), or in somatomotor processing (P. Tang et al, 2021). These findings converge, on the one hand, with the aforementioned results of this systematic review on the association of inflammation with structural MRI abnormalities in regions involved in emotion regulation in BD (Bai et al, 2020;Chen et al, 2019;Chung et al, 2013;Mohite et al, 2021;Papiol et al, 2008;Poletti et al, 2019;Savitz et al, 2015;Tu et al, 2017).…”

Section: 062022supporting

confidence: 51%

“…Results on functional MRI remain non-conclusive since studies are especially scarce (n=7) and heterogeneous. This may be due to the different inflammatory markers assessed, to the functional MRI analysis methods employed, or to the heterogenous BD populations included, with studies focusing on pediatric BD (Barzman et al, 2014), on BD type I (Furlan et al, 2019) or type II (Tang et al, 2021), on BD patients in different mood states or treatment-naive (P. .…”

Section: Discussionmentioning

confidence: 99%

“…7 studies (Barzman et al, 2014;Furlan et al, 2019;Poletti et al, 2017;Tang et al, 2021;Tseng et al, 2021;Tu et al, 2017) focused on the link between immune and inflammatory traits or markers 30.06.2022 and functional MRI abnormalities in BD patients, contributing data from 248 BD patients (173 plus 75 patients from the only study on both MRI techniques (Tu et al, 2017)). Three studies (P. Tang et al, 2021;Tseng et al, 2021) focused on rsFC measures while the others employed task-based functional MRI data (see Table 2).…”

Section: Functional Mri Correlates Of Inflammation In Bipolar Disordermentioning

confidence: 99%

“…Almost all studies found results for a different inflammatory marker each. Only two articles (P. Tang et al, 2021) both reported findings regarding the pro-inflammatory cytokine IL-6 (among other inflammatory markers). However, while Chen et al (P. highlighted a significant negative correlation between IL-6 level and rsFC between the left postcentral gyrus and the right posterior insula (p = 0.043), Tang et al (Tang et al, 2021) did not confirm this finding, but showed a negative correlation between IL-8 and right precentral gyrus rsFC (p =0.004) instead.…”

Section: Functional Mri Correlates Of Inflammation In Bipolar Disordermentioning

confidence: 99%

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Structural and functional MRI correlates of inflammation in bipolar disorder: a systematic review

Saccaro¹,

Crokaert²,

Piguet³

2022

Preprint

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Bipolar disorder (BD) is a common affective disorder characterized by recurrent oscillations between mood states and associated with inflammatory diseases and chronic inflammation. However, data on MRI abnormalities in BD and their relationship with inflammation are heterogeneous and no review has recapitulated them. In this pre-registered (PROSPERO: CRD42022308461) systematic review we searched Web of Science Core Collection and PubMed for articles correlating functional or structural MRI measures with immune-related markers in BD. We included 23 studies (6 on functional, 16 on structural MRI findings, 1 on both, including 1’233 BD patients). Despite heterogeneity between studies, a qualitative synthesis suggests that the links between immune traits and functional or structural MRI alterations point toward brain areas involved in affective and somatomotor processing, with a trend toward a negative correlation between peripheral inflammatory markers and brain regions volume. We discuss how disentangling the complex relationship between stress, the immune system and MRI alterations in BD may unveil mechanisms underlying symptoms pathophysiology, potentially with quickly translatable diagnostic, prognostic, and therapeutic implications.

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Section: 062022supporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Functional Mri Correlates Of Inflammation In Bipolar Disordermentioning

confidence: 99%

Section: Functional Mri Correlates Of Inflammation In Bipolar Disordermentioning

confidence: 99%

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Structural and functional MRI correlates of inflammation in bipolar disorder: a systematic review

Saccaro¹,

Crokaert²,

Piguet³

2022

Preprint

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“…Our findings also showed significant correlations between levels of IL-8 and FARSB in patients with BD-II. Serum IL-8 levels have been found to be increased in patients with BD-II depression, and an increase in IL-8 has also been inversely correlated with functional connectivity in the right precentral gyrus [38]. The positive correlation between FARSB and IL-8 levels seems to support the notion that inflammation plays an important role in the pathogenesis of BD-II.…”

Section: Farsb Protein and Bdnfmentioning

confidence: 75%

Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder

Lee

Wang

et al. 2021

JPM

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We have previously identified five candidate proteins (matrix metallopeptidase 9 (MMP9), phenylalanyl-TRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin Type 9 (PCSK9)) as potential biomarkers for bipolar II disorder (BD-II). These candidate proteins have been associated with neuroprotective factors (BDNF) and inflammatory factors (cytokines, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α)). However, the correlations between these proteins with plasma BDNF and inflammatory factors remain unknown. We recruited a total of 185 patients with BD-II and 186 healthy controls. Plasma levels of candidate proteins, BDNF, cytokines (TNF-α, CRP, and interleukin-8 (IL-8)) were assessed from each participant. The correlations between levels of candidate proteins, BDNF, and cytokines were analyzed. In the BD-II group, we found that the level of FARSB was positively correlated with the BDNF level (r = 0.397, p < 0.001) and IL-8 (r = 0.320, p < 0.001). The CA-1 level positively correlated with IL-8 (r = 0.318, p < 0.001). In the control group, we found that the FARSB level positively correlated with the BDNF level (r = 0.648, p < 0.001). The CA-1 level positively correlated with TNF-α (r = 0.231, p = 0.002), while the MMP-9 level positively correlated with the CRP level (r = 0.227, p = 0.002). Our results may help in clarifying the underlying mechanism of these candidate proteins for BD-II.

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Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

et al. 2023

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Objectives : Bipolar disorder (BD) is a severe, chronic, affective disorder characterized by recurrent switching between mood states, psychomotor and cognitive symptoms, which can linger in euthymic states as residual symptoms. Hippocampal alterations may play a key role in the neural processing of BD symptoms. However, its dynamic functional connectivity (dFC) remains unclear. Therefore, the present study explores hippocampal dFC in relation to BD symptoms. Methods : We assessed hippocampus‐based dFC coactivation patterns (CAPs) on resting‐state fMRI data of 25 euthymic BD patients and 25 age‐ and sex‐matched healthy controls (HC). Results : Bilateral hippocampal dFC with somatomotor networks (SMN) was reduced in BD, compared to HC, while at the same time dFC between the left hippocampus and midcingulo‐insular salience system (SN) was higher in BD. Correlational analysis between CAPs and clinical scores revealed that dFC between the bilateral hippocampus and the default‐like network (DMN) correlated with depression scores in BD. Furthermore, pathological hyperconnectivity between the default mode network (DMN) and SMN and the frontoparietal network (FPN) was modulated by the same depression scores in BD. Conclusions : Overall, we observed alterations of large‐scale functional brain networks associated with decreased flexibility in cognitive control, salience detection, and emotion processing in BD. Additionally, the present study provides new insights on the neural architecture underlying a self‐centered perspective on the environment in BD patients. dFC markers may improve detection, treatment, and follow‐up of BD patients and of disabling residual depressive symptoms in particular.

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Inflammation is correlated with abnormal functional connectivity in unmedicated bipolar depression: an independent component analysis study of resting-state fMRI

Cited by 18 publications

References 100 publications

Structural and functional MRI correlates of inflammation in bipolar disorder: a systematic review

Structural and functional MRI correlates of inflammation in bipolar disorder: a systematic review

Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder

Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

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