Inflammation is associated to volume status in peritoneal dialysis patients

Ünal, Aydın; Kavuncuoğlu, Feridun; Duran, Mustafa; Oğuz, Fatih; Koçyiğit, İsmail; Sipahioğlu, Murat Hayri; Tokgöz, Bülent; Oymak, Oktay

doi:10.3109/0886022x.2015.1040337

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…In PD patients, the same pattern of correlation has been reported 108,109,116,117 . For example, CRP levels were significantly increased in hypervolemic PD patients, and the severity of fluid overload 117,118 . Similarly, serum IL‐6 levels correlated with overhydration and NT‐pro‐BNP levels in PD patients 119 …”

Section: Inflammation and Fluid Overloadsupporting

confidence: 57%

“…108,109,116,117 For example, CRP levels were significantly increased in hypervolemic PD patients, and the severity of fluid overload. 117,118 Similarly, serum IL-6 levels correlated with overhydration and NT-pro-BNP levels in PD patients. 119 The pathogenic link between fluid overload and inflammation is an active area of research.…”

Section: Inflammation and Fluid Overloadmentioning

confidence: 92%

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From MIA to FIFA: The vicious matrix of frailty, inflammation, fluid overload and atherosclerosis in peritoneal dialysis

Chan¹,

Fung²,

Szeto

et al. 2023

Nephrology

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Cardiovascular disease (CVD) is a major cause of mortality and morbidity in peritoneal dialysis (PD) patients. Two decades ago, the common co-existence of malnutrition and systemic inflammation PD patients with atherosclerosis and CVD led to the proposed terminology of 'malnutrition-inflammation-atherosclerosis (MIA) syndrome'. Although the importance of malnutrition is well accepted, frailty represents a more comprehensive assessment of the physical and functional capability of the patient and encompasses the contributions of sarcopenia (a key component of malnutrition), obesity, cardiopulmonary as well as neuropsychiatric impairment.In recent years, it is also increasingly recognized that fluid overload is not only the consequence but also play an important role in the pathogenesis of CVD. Moreover, fluid overload is closely linked with the systemic inflammatory status, presumably by gut oedema, gastrointestinal epithelial barrier dysfunction and leakage of bacterial fragments to the systemic circulation. There are now a wealth of published evidence to show intricate relations between frailty, inflammation, fluid overload and atherosclerotic disease in patients with chronic kidney disease (CKD) and those on PD, a phenomenon that we propose the term 'FIFA complex'. In this system, frailty and atherosclerotic disease may be regarded as two patientoriented outcomes, while inflammation and fluid overload are two inter-connected pathogenic processes. However, there remain limited data on how the treatment of one component affect the others. It is also important to define how treatment of fluid overload affect the systemic inflammatory status and to develop effective anti-inflammatory strategies that could alleviate atherosclerotic disease and frailty.

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Section: Inflammation and Fluid Overloadsupporting

confidence: 57%

Section: Inflammation and Fluid Overloadmentioning

confidence: 92%

From MIA to FIFA: The vicious matrix of frailty, inflammation, fluid overload and atherosclerosis in peritoneal dialysis

Chan¹,

Fung²,

Szeto

et al. 2023

Nephrology

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“…It is well known, inter-alia on the basis of many studies with dialyzed subjects, that there is a strict correlation between the inflammation involving TNFα, IL-1β, IL-6 and MMPs and hydration changes [9][10][11]. In a cross-sectional study, including 159 patients subjected to peritoneal dialysis, Unal et al [19] demonstrated that in hypervolemic patients compared with euvolemic patients, hs-CRP value levels were significantly higher. The ECW/TBW ratio positively correlated with hs-CRP.…”

Section: Discussionmentioning

confidence: 99%

Status of hydration assessed by bioelectrical impedance analysis: a valuable predictive factor for radiation-induced oral mucositis in head and neck cancer patients

et al. 2018

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Background Apart from surgery, the methods of treatment of HNC are radiotherapy (RTH) and/or chemotherapy (CRTH/ CHT). One of the most frequent and serious complications of RTH is oral mucositis (OM). There is a strict correlation between the inflammation and the status of hydration. The aim of the study was to evaluate the changes in hydration, occurring in the course of RTH, measured by means of bioelectrical impedance analysis (BIA) and to analyze them in correlation with the intensification of OM in HNC patients. Patients and methods Data from 49 HNC patients (stages I-IV) were analyzed. All of them were irradiated using IMRT technique with the doses of 50-70 Gy. Oral mucositis (OM) was evaluated according to RTOG/EORTC guidelines. BIA was performed using ImpediMed bioimpedance analysis SFB7 BioImp v1.55. Results In the fourth week of RTH, 4-5 days before the occurrence of severe OM, it was found that patients with OM grade 3 or higher compared to OM grade 2 or lower had significantly: lower ICW% values (respectively, 53.02% vs 50.72%; p = 0.0047), higher: ECW%: (47.95% vs 46.92%; p = 0.0020), TBW% (respectively, 56.34% vs 51.06%; p = 0.0455), ECW/ ICW (respectively, 0.96 vs 0.86; p = 0.0007) and ECW/TBW (respectively, 0.49 vs 0.46, p = 0.0033). Conclusion Our study indicates that HNC patients undergo changes in hydration in the course of RTH. We have also confirmed that the intensification of OM leads to ICW decrease and the increase of ECW, TBW as well as ECW/ICW and ECW/ TBW values.

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Phase angle and extracellular water-to-total body water ratio estimated by bioelectrical impedance analysis are associated with levels of hemoglobin and hematocrit in patients with diabetes

Hori¹,

Nakamura²,

Yamagami³

et al. 2023

Heliyon

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Inflammation is associated to volume status in peritoneal dialysis patients

Cited by 5 publications

References 33 publications

From MIA to FIFA: The vicious matrix of frailty, inflammation, fluid overload and atherosclerosis in peritoneal dialysis

From MIA to FIFA: The vicious matrix of frailty, inflammation, fluid overload and atherosclerosis in peritoneal dialysis

Status of hydration assessed by bioelectrical impedance analysis: a valuable predictive factor for radiation-induced oral mucositis in head and neck cancer patients

Phase angle and extracellular water-to-total body water ratio estimated by bioelectrical impedance analysis are associated with levels of hemoglobin and hematocrit in patients with diabetes

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